Results 171 to 180 of about 16,480 (226)

Activity-based probes and chemical proteomics uncover the biological impact of targeting HMG-CoA Synthase 1 in the mevalonate pathway. [PDF]

J Biol Chem
Yi SA, Sun L, Rao Y, Ordureau A, Lewis JS, An H.   +5 more
europepmc   +1 more source

Assessing the impact of PCSK9 and HMGCR inhibitor on reproductive endocrine diseases: A drug-target Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Aru N, Yang C, Chen Y, Liu J.
europepmc   +1 more source

Association between statin use and the risk of colorectal cancer in patients with inflammatory bowel disease: a systematic review and meta-analysis. [PDF]

Front Immunol
Ding M, Liu Y, Zhang Y, Qiu Y.
europepmc   +1 more source

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Reversible modulation of liver hydroxymethylglutaryl CoA reductase

Life Sciences, 1978
Abstract The activity of rat liver microsomal hydroxymethylglutaryl CoA reductase (HMG CoA reductase, E.C. 1.1.1.34) is severely diminished when microsomes are preincubated with both ATP and Mg 2+ before the enzyme is assayed. Sensitivity to MgATP is progressively lost when microsomes are extracted with buffers.
D M, Gibson, T S, Ingebritsen
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Modulation of rat liver hydroxymethylglutaryl-CoA reductase by protein phosphatases: Purification of nonspecific hydroxymethylglutaryl-CoA reductase phosphatases

Archives of Biochemistry and Biophysics, 1985
Four phosphoprotein phosphatases, with the ability to act upon hydroxymethylglutaryl (HMG)-CoA reductase, phosphorylase, and glycogen synthase have been purified from rat liver cytosol through a process that involves DEAE-cellulose, aminohexyl-Sepharose-4B, and Bio-Gel A 1.5 m chromatographies.
V E, Calvet, G, Gil, F G, Hegardt
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Hydroxymethylglutaryl-CoA Reductase

1980
The reaction catalyzed by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [hydroxymethylglutaryl-CoA reductase (NADPH), EC 1.1.1.34] involves reductive deacylation of HMG-CoA to mevalonate and requires two moles of NADPH (Fig. 1).
W E, Brown, V W, Rodwell
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The regulation of hydroxymethylglutaryl-CoA reductase in cultured cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1988
Growth-stimulated synchronized cells exhibit a rapid increase in 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.88) activity prior to the onset of DNA synthesis. Under normal culture conditions, HMG-CoA reductase activity exhibits wide variations among experiments.
K, Tavangar, F B, Kraemer
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The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

Letters in Drug Design & Discovery, 2019
High cholesterol and triglyceride levels are mainly related to further generation of lifethreating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
ERDOĞAN ORHAN, İLKAY, Gulcan, Hayrettin Ozan, Yigitkan, Serkan   +2 more
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Saprophytic production of Clavine alkaloids and activity of Hydroxymethylglutaryl-CoA reductase

Folia Microbiologica, 1986
In submerged Claviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production and of sterol content. During the first alkaloid phase, cell mevalonate was involved in the biosynthesis of both alkaloids and steroids.
V, Kren, S, Pazoutová, V, Rylko, Z, Rehácek   +3 more
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