Results 181 to 190 of about 16,480 (226)
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Hydroxymethylglutaryl‐CoA reductase, a key enzyme in phytosterol synthesis?
Lipids, 1986AbstractHydroxymethylglutaryl‐CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of isoprenoid compounds functional in plant cells, with phytosterols representing one class of major importance. Recently, it has shown possible to solubilize and purify the membrane‐bound enzyme from a heavy membrane fraction
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Dietary Coenzyme Q10 Suppressed Hepatic Hydroxymethylglutaryl-CoA Reductase Activity in Laying Hens
Bioscience, Biotechnology, and Biochemistry, 2013The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn ...
Kazuhisa, Honda +4 more
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Plant Molecular Biology, 2000
The genus Morus consists of trees and shrubs, which are distributed in temperate and subtropical regions. Commonly known as mulberry, a few of the Morus species are valued for their foliage, which constitutes the chief feed for mulberry silkworms. Steroids and isoprenoid compounds present in the foliage not only add nutritive factors to the feed but ...
A K, Jain, R M, Vincent, C L, Nessler
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The genus Morus consists of trees and shrubs, which are distributed in temperate and subtropical regions. Commonly known as mulberry, a few of the Morus species are valued for their foliage, which constitutes the chief feed for mulberry silkworms. Steroids and isoprenoid compounds present in the foliage not only add nutritive factors to the feed but ...
A K, Jain, R M, Vincent, C L, Nessler
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Experimental and Molecular Pathology, 1993
We studied 56 patients affected by primary hypercholesterolemia treated with placebo for 1 month and with simvastatin (20 mg/day) or pravastatin (20 mg/day) for 6 months during a double-blind clinical trial. At 1-month intervals we determined the following parameters in the serum: total and HDL cholesterol, triglycerides, and apolipoprotein A-1 and B ...
R A, Rabini +6 more
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We studied 56 patients affected by primary hypercholesterolemia treated with placebo for 1 month and with simvastatin (20 mg/day) or pravastatin (20 mg/day) for 6 months during a double-blind clinical trial. At 1-month intervals we determined the following parameters in the serum: total and HDL cholesterol, triglycerides, and apolipoprotein A-1 and B ...
R A, Rabini +6 more
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Applied Microbiology and Biotechnology, 1998
The enzyme 3-hydroxy-3-methylglutaryl-co-enzyme-A (HMG-CoA) reductase is known as the rate limiting enzyme in early sterol biosynthesis in eukaryotic cells. To eliminate this regulation in the yeast Saccharomyces cerevisiae, a truncated HMG1 gene, producing a form of the enzyme that lacks the membrane-binding region (i.e.
T, Polakowski, U, Stahl, C, Lang
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The enzyme 3-hydroxy-3-methylglutaryl-co-enzyme-A (HMG-CoA) reductase is known as the rate limiting enzyme in early sterol biosynthesis in eukaryotic cells. To eliminate this regulation in the yeast Saccharomyces cerevisiae, a truncated HMG1 gene, producing a form of the enzyme that lacks the membrane-binding region (i.e.
T, Polakowski, U, Stahl, C, Lang
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
Abstract Using MgATP-inactivated rat liver microsomal hydroxymethylglutaryl-CoA reductase (reductase, EC 1.1.1.34) as substrate, we detected reductase phosphatase activity in liver tissue of several vertebrates. Rodent liver reductase phosphatase is primarily cytosolic but may have some affinity for membranes.
W E, Brown, V W, Rodwell
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Abstract Using MgATP-inactivated rat liver microsomal hydroxymethylglutaryl-CoA reductase (reductase, EC 1.1.1.34) as substrate, we detected reductase phosphatase activity in liver tissue of several vertebrates. Rodent liver reductase phosphatase is primarily cytosolic but may have some affinity for membranes.
W E, Brown, V W, Rodwell
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Journal of Cancer Research and Clinical Oncology, 1995
Competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase are currently used to treat patients with hypercholesterolaemia. These inhibitors affect not only cholesterol biosynthesis, but also the production of non-steroidal mevalonate derivatives, that are involved in a number of growth-regulatory processes.
A, Gebhardt, A, Niendorf
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Competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase are currently used to treat patients with hypercholesterolaemia. These inhibitors affect not only cholesterol biosynthesis, but also the production of non-steroidal mevalonate derivatives, that are involved in a number of growth-regulatory processes.
A, Gebhardt, A, Niendorf
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Hydroxymethylglutaryl coA reductase (NADPH) in the latex of Hevea brasiliensis
Phytochemistry, 1982Abstract The activity of hydroxymethylglutaryl CoA reductase (NADPH) (EC 1.1.1.34) was studied in the latex of regularly tapped mature trees of Hevea brasiliensis . The reductase activity was found mainly (95% of the total activity) in the pellet fraction (40 000 g ) of the centrifuged latex.
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Biological Chemistry Hoppe-Seyler, 1987
Microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase kinase activity is enhanced about 5 fold by 2 mM of either AMP or ADP. Activation constants, Ka, for AMP and ADP are 17 microM and 430 microM respectively, showing that AMP is a more potent activator than ADP.
A, Ferrer +3 more
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Microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase kinase activity is enhanced about 5 fold by 2 mM of either AMP or ADP. Activation constants, Ka, for AMP and ADP are 17 microM and 430 microM respectively, showing that AMP is a more potent activator than ADP.
A, Ferrer +3 more
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Life Sciences, 2008
Preadipocytes are considered to play a role in adipose tissue inflammation in obesity. The purpose of this study was to determine whether hydroxymethylglutaryl-CoA reductase inhibitor (statin) modulates the nitric oxide (NO) production via inducible NO synthase (iNOS) in preadipocytes.
Kazushige, Dobashi +5 more
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Preadipocytes are considered to play a role in adipose tissue inflammation in obesity. The purpose of this study was to determine whether hydroxymethylglutaryl-CoA reductase inhibitor (statin) modulates the nitric oxide (NO) production via inducible NO synthase (iNOS) in preadipocytes.
Kazushige, Dobashi +5 more
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