Results 51 to 60 of about 16,480 (226)

Risk of new-onset diabetes associated with statin use

SAGE Open Medicine, 2015
Objective: To identify and assess studies investigating the association between statins and new-onset diabetes and determine the clinical significance of this risk.
Robert D Beckett, Sarah M Schepers, Sarah K Gordon   +2 more
doaj   +1 more source

Effectiveness of statin treatment for recurrent stroke according to stroke subtypes [PDF]

Journal of Medicine and Life Science
Understanding the effectiveness of statin treatment is essential for developing tailored stroke prevention strategies. We aimed to evaluate the efficacy of statin treatment in preventing recurrent stroke among patients with various ischemic stroke ...
Min-Surk Kye, Do Yeon Kim, Dong-Wan Kang, Baik Kyun Kim, Jung Hyun Park, Hyung Seok Guk, Nakhoon Kim, Sang-Won Choi, Dongje Lee, Yoona Ko, Jun Yup Kim, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae,   +15 more
doaj   +1 more source

Rosuvastatin in Combination With Bortezomib Promotes Osteogenesis in Myeloma Bone Disease by Inhibiting the Secretion of CCL3

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu, Mingxu Hui, Fan Yang, Bo Huang, Nian Liu, Yuchan He, Xiaotao Wang   +6 more
wiley   +1 more source

Chemoprevention of Gastric Cancer: Statins

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2017
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required.
Sang Hyeon Choi, Gwang Ho Baik
doaj   +1 more source

Synthetic biology: advancing biological frontiers by building synthetic systems [PDF]

, 2012
Advances in synthetic biology are contributing to diverse research areas, from basic biology to biomanufacturing and disease therapy.
Chen, Yvonne Y., Galloway, Kate E., Smolke, Christina D.   +2 more
core   +5 more sources

Rethinking Statin Dosage in Coronary Disease

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Simon B. Dimmitt, Hans G. Stampfer, Michael C. Kennedy, Jennifer H. Martin   +3 more
wiley   +1 more source

Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins

Journal of Inflammation
Background HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotropic and lipid-lowering properties. Herein, we reviewed the effects of statins on the CCL2/CCR2 axis.
Hanieh Gholamalizadeh, Behzad Ensan, Sercan Karav, Tannaz Jamialahmadi, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Effects of fluvastatin on insulin resistance and cardiac morphology in hypertensive patients [PDF]

, 2011
Among hypertensive patients, cardiovascular disease morbidity is common, even in those who are adequately treated. New pharmacological strategies to mitigate the burden of arterial hypertension are needed.
Batista, M. C., Buffani, A., Kohlmann, O., Ribeiro, A. B., Tavares, A., Teixeira, A. A., Zanella, M. T.   +6 more
core   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, Volume 13, Issue 6, 30 January 2026.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening. [PDF]

The Plant Cell, 1989
The activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and the level of its mRNA have been determined at various stages of tomato fruit development. The HMGR reaction makes mevalonate, a necessary component in the synthesis of all isoprene containing compounds, such as sterols and carotenoids.
J O, Narita, W, Gruissem
openaire   +2 more sources