Results 61 to 70 of about 16,480 (226)

Effects of Fibre-Enriched Diets on Tissue Lipid Profiles of MSG Obese Rats [PDF]

, 2012
In order to investigate the influence of some fibre-enriched diets on tissue lipids in an animal model of obesity induced by the administration of monosodium glutamate (MSG), obese rats were fed diets containing 30% of Acha, Cassava, Maize and Plantain
Ademuyiwa, Oladipo, Balogun, Elizabeth A., Olayiwola, I.O., Rotimi, Oluwakemi A   +3 more
core   +1 more source

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi, Jin‐Seok Jung, Yie‐sung Seo, Sungmin Song, Jeehye Ham, Hannah Chung, Yousef Ramadan, Kangchan Choi   +7 more
wiley   +1 more source

Diagnosis of Statin-Induced Necrotizing Myopathy: Contribution of Anti-HMGCR Antibodies

Acta Médica Portuguesa, 2022
Over the last few years, several cases of statin-induced necrotizing myopathy have been described. This myopathy is characterized by the necrosis of muscle fibers and the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR ...
Cláudia Fidalgo, Alice Mendes, Rosário Cunha, Fernando Rodrigues   +3 more
doaj   +1 more source

Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]

Pharmacognosy Journal, 2018
Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to determine the molecular dynamics simulation of HMG-CoA reductase inhibitors from Gnetum gnemon L ...
Artha, Yuditya, Arrahman, Arif, Azminah, , Yanuar, Arry   +3 more
openaire   +1 more source

Effect of Ceiling Fans on Core Temperature in Bed‐Resting Older Adults Exposed to Indoor Overheating

Journal of the American Geriatrics Society, Volume 74, Issue 1, Page 200-204, January 2026.
ABSTRACT Background Rising global temperatures have increased indoor overheating risks, posing significant health threats to vulnerable populations, particularly older adults. While electric fans are recommended for cooling at temperatures up to 40°C, the efficacy of ceiling fans in very warm indoor temperatures (~31°C) remains understudied.
Fergus K. O'Connor, Robert D. Meade, Kristina‐Marie T. Janetos, Caroline Li‐Maloney, Ronald J. Sigal, Pierre Boulay, Glen P. Kenny   +6 more
wiley   +1 more source

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury [PDF]

, 2013
Background: Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and systemic organ failure.
A Linder, Cecilia M O’Kane, Daniel F McAuley, DF McAuley, DG Sinclair, G Weitz-Schmidt, H Herwald, H Sengelov, H Tapper, Heiko Herwald, J Grommes, JR Jacobson, K Tsushima, Karim Dib, KP Steinberg, M Shyamsundar, MB Fessler, MS Chew, MS Diamond, Murali Shyamsundar, N Gautam, O Soehnlein, O Soehnlein, S Steiner, S Zhang, Thelma R Craig, TR Craig, WM Shafer   +27 more
core   +1 more source

Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms

iNew Medicine, Volume 1, Issue 1, December 2025.
ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang, Shuo Chen, Suowen Xu, Jianping Weng   +3 more
wiley   +1 more source

Hydroxymethylglutaryl CoA reductase and the modulation of microsomal cholesterol content by the nonspecific lipid transfer protein.

Journal of Lipid Research, 1984
The influence of membrane cholesterol content on 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase, EC 1.1.1.34) in rat liver microsomes was investigated.
G P van Heusden, K W Wirtz
doaj   +1 more source

Underuse of statins for secondary prevention of atherosclerotic cardiovascular disease events among ambulatory surgical patients

Preventive Medicine Reports, 2020
Although statins are highly effective for reducing cardiovascular disease events, prior studies demonstrate their significant underuse in the US population, including among those with known atherosclerotic disease.
Robert B. Schonberger, Vivek Vallurupalli, Hollie Matlin, Daina Blitz, Adambeke Nwozuzu, Brian Barron, Yuemei Zhang, Feng Dai, Daniel Jacoby, Khurram Nasir, Amit Bardia   +10 more
doaj   +1 more source

Recent advances: rheumatology [PDF]

, 2000
No abstract ...
Madhok, R., Kerr, H., Capell, H.A.
core   +4 more sources