Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. [PDF]
, 2014 BACKGROUND: Efficacy of statins has been extensively studied, with much less information reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on unintended effects is often insufficient to support hypotheses generated ...
Adler, Alma +5 more
core +2 more sources
Role of Statin Drugs for Polycystic Ovary Syndrome
Journal of Family and Reproductive Health, 2017 Objective: To review the potential role and specific impact of statin drugs in women with PCOS. The evidence for this use of statins in PCOS is limited and still under further investigation.
Lisa Cassidy Vu +2 more
doaj
Gut and Liver, 2019 Background/Aims Statins have been postulated to lower the risk of colorectal neoplasia. No studies have examined any possible chemopreventive effect of statins in patients with inflammatory bowel disease (IBD) undergoing colorectal cancer (CRC ...
Shailja C. Shah +9 more
doaj +1 more source
Statin use decreases coagulation in users of vitamin K antagonists [PDF]
, 2016 Purpose: The purpose of the study is to determine the immediate and long-term effect of statins on coagulation in patients treated with vitamin K antagonists (VKAs). Methods: We selected patients on VKAs of two Dutch anticoagulation clinics who initiated
Biedermann, J.S. (Joseph) +5 more
core +4 more sources
Marked differences in frequencies of statin therapy relevant SLCO1B1 variants and haplotypes between Roma and Hungarian populations [PDF]
, 2015 BACKGROUND: SLCO1B1 polymorphisms are relevant in statin pharmacokinetics. Aim of this study was to investigate the genetic variability and haplotype profile of SLCO1B1 polymorphisms in Roma and Hungarian populations.
Agnes Nagy +7 more
core +1 more source
Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients [PDF]
, 2017 Aims Statin therapy is associated with important benefits for patients at risk of, and with, established cardiovascular disease. There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if
Berwanger, Otavio +6 more
core
Lipid management in patients newly referred to a vascular surgery outpatient clinic
JVS-Vascular InsightsObjective: To evaluate the lipid management of patients with atherosclerotic vascular disease at the time of first outpatient vascular surgery consult to identify potential opportunities for improved dyslipidemia pharmacotherapy and monitoring.
Martina Vergouwen, BN +3 more
doaj +1 more source
Additive Effects of Ezetimibe and Statins in Managing Elevated LDL-C: An Approach to Reducing Cardiovascular Risk [PDF]
Journal of Advanced Biomedical SciencesElevated low-density lipoprotein cholesterol (LDL-C) is a key modifiable risk factor for cardiovascular disease. While statins are the cornerstone of LDL-C-lowering therapy, their long-term use may result in dose-dependent adverse effects.
Narges Yaghoobi +2 more
doaj
Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis [PDF]
, 2017 Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated the effects of simvastatin on survival, organ and mitochondrial function, tissue and plasma ubiquinone levels and ...
Backman, JT +9 more
core
Brazilian Journal of Cardiovascular SurgeryObjective: The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic ...
Carlos Henrique Marques dos Santos +11 more
doaj +1 more source