Modelling approach to simulate reductions in LDL cholesterol levels after combined intake of statins and phytosterols/-stanols in humans [PDF]
, 2011 Background To examine the effects on LDL cholesterol of the combined use of statins and phytosterols/-stanols, in vivo studies and clinical trials are necessary. However, for a better interpretation of the experimental data as well as to possibly predict
Simone RBM Eussen +3 more
core +1 more source
Medical Journal of Australia, Volume 224, Issue 2, February 2026.ABSTRACT Introduction The Australian clinical guideline for diagnosing and managing acute coronary syndromes 2025 establishes a new clinical standard for the diagnosis and management of acute coronary syndromes (ACS) in Australia. The new guideline replaces the 2016 guideline, representing the first major update in nearly a decade.
David B. Brieger +9 more
wiley +1 more source
Short-Term Therapy with High Dose Atorvastatin in Patients with Coronary Artery Disease Can Reduce Inflammatory Process [PDF]
Acta Medica Iranica, 2010 Coronary heart disease is the leading cause of death and disability in adults. The association between acute coronary syndrom (ACS) and elevated serum high sensitivity c-reactive protein (hsCRP) suggests that chronic inflammation of the coronary arterial
Vida Nesar Hossein +2 more
doaj +1 more source
Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment?
Arquivos Brasileiros de Cardiologia, 2018 Background: Long-term safety, effectiveness and criteria for treatment with statins in children are still unclear in clinical practice. There is very limited evidence for the use of medication to treat children with dyslipidemia secondary to obesity who ...
Graciane Radaelli +4 more
doaj +1 more source
Transgenic tobacco overexpressing Brassica juncea HMG-CoA synthase 1 shows increased plant growth, pod size and seed yield [PDF]
, 2014 Seeds are very important not only in the life cycle of the plant but they represent food sources for man and animals. We report herein a mutant of 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGS), the second enzyme in the mevalonate (MVA) pathway ...
Bach, TJ +5 more
core +2 more sources
Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis
Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi +7 more
wiley +1 more source
Effects of exercise on the cognition of older women treated with lovastatin
Biomédica: revista del Instituto Nacional de Salud, 2018 Introduction: The deterioration of cognition is highly predominant in older adults. Objective: The aim of this study was to analyze the effects of a walking program on the cognition and blood concentration of lipids in women over 60 years of age who were
Edgardo Molina-Sotomayor +5 more
doaj +1 more source
Renoprotective effect of statin: a ischemia-reperfusion animal model [PDF]
, 2010 OBJETIVO: A lesão renal aguda isquêmica, de causa multifatorial, apresenta morbidade e mortalidade alarmantes. A estatina, inibidor de HMG-CoA redutase, tem demonstrado papel renoprotetor, com componente antioxidante, antiinflamatório e vascular.
NAKAMURA, Sandra Hideko +3 more
core +2 more sources
Effect of Ceiling Fans on Core Temperature in Bed‐Resting Older Adults Exposed to Indoor Overheating
Journal of the American Geriatrics Society, Volume 74, Issue 1, Page 200-204, January 2026.ABSTRACT Background Rising global temperatures have increased indoor overheating risks, posing significant health threats to vulnerable populations, particularly older adults. While electric fans are recommended for cooling at temperatures up to 40°C, the efficacy of ceiling fans in very warm indoor temperatures (~31°C) remains understudied.
Fergus K. O'Connor +6 more
wiley +1 more source
Cholesterol 24S-Hydroxylase overexpression inhibits the liver X receptor (LXR) pathway by activating small guanosine triphosphate-binding proteins (sGTPases) in neuronal cells [PDF]
, 2014 The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in ...
Björkhem, Ingemar +7 more
core +1 more source