Results 71 to 80 of about 762,287 (195)

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

open access: yesFood Bioengineering, Volume 5, Issue 1, Page 105-123, March 2026.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob   +3 more
wiley   +1 more source

Genetic Polymorphisms and Statin-Associated Side Effects: The Role of SLCO1B1 and Additional Risk Factors

open access: yesSoutheastern European Medical Journal
Statins are first-line agents for managing dyslipidemia, primarily prescribed to reduce low-density lipoprotein cholesterol (LDL-C) and prevent atherosclerotic cardiovascular disease (ASCVD).
Romana Marušić   +3 more
doaj   +1 more source

Type I and type III collagen immunoexpression in rabbit skin biopsy samples treated with rosuvastatin gel and autologous platelet-rich plasma [PDF]

open access: yesActa Cirúrgica Brasileira
Purpose: To evaluate whether the joint use of autologous platelet-rich plasma (aPRP) and rosuvastatin (RSV) in biopsies of dermal wounds induced in rabbits results in an additive effect on the immunoexpression of collagens type I and III, optimizing the ...
Cristoffer da Silva Santana   +7 more
doaj   +1 more source

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

open access: yesNeuroprotection, Volume 4, Issue 1, Page 30-47, March 2026.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan   +5 more
wiley   +1 more source

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 [PDF]

open access: yes, 2008
The identification of potential new anti-tubercular cemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB).Libraries of NAS-21 and NAS-91 analogues were synthesized and ...
Brown, Alistair K.   +5 more
core   +2 more sources

Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar   +2 more
wiley   +1 more source

Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors

open access: yesThe 1st International Electronic Conference on Clinical Medicine, 2021
Hélida Maravilha Dantas e Sousa Almeida   +2 more
openaire   +1 more source

HMG-CoA reductase inhibitors in osteoporosis: do they reduce the risk of fracture?

open access: yes, 2003
Osteoporosis affects a large number of people in industrialised countries. It has clinical and public-health impacts, most importantly due to subsequent fractures.
Schlienger RG, Meier CR
core   +1 more source

HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture [PDF]

open access: yes, 1997
HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture. Renal cyst formation in polycystic diseases or after nephron reduction is attributed to enhanced tubular cell proliferation with unbalanced cell death.
Friedlander, Gérard   +3 more
core   +1 more source

Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment?

open access: yesArquivos Brasileiros de Cardiologia, 2018
Background: Long-term safety, effectiveness and criteria for treatment with statins in children are still unclear in clinical practice. There is very limited evidence for the use of medication to treat children with dyslipidemia secondary to obesity who ...
Graciane Radaelli   +4 more
doaj   +1 more source

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