Results 81 to 90 of about 13,154 (208)

Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population. [PDF]

, 2014
BACKGROUND: The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing ...
Anzivino C, BALDELLI, Enrica, BERTOLOTTI, Marco, Carulli N., CARULLI, Lucia, Del Puppo M, LORIA, Paola, Magni A, MUSSI, Chiara, OGNIBENE, Silvia, Pellegrini E   +10 more
core   +1 more source

Evaluation the effects of red yeast rice in combination with statin on lipid profile and inflammatory indices; a randomized clinical trial

BMC Nutrition, 2022
Background Dyslipidemia is a prominent cause of cardiovascular disease as it leads to inflammation and plaque deposition within arteries. Treatment includes lifestyle modifications and lipid-lowering medications.
Ali Tavan, Saam Noroozi, Bardia Zamiri, Reza Gholchin Vafa, Mohammadhossein Rahmani, Mohammadjavad Mehdizadeh Parizi, Amin Ahmadi, Reza Heydarzade, Mohammad Montaseri, Seyed Ali Hosseini, Javad Kojuri   +10 more
doaj   +1 more source

Influence of statin use on clinicopathological characteristics of localized prostate cancer and outcomes obtained after radical prostatectomy: a single center study [PDF]

, 2015
To assess the impact of statin use on biochemical recurrence (BCR) of prostate cancer after radical prostatectomy (RP)
Cattarino, Susanna, Comperat, Eva, Cussenot, Olivier, Drouin, Sarah J, Leon, Priscilla, Mozer, Pierre, Renard Penna, Raphaële, Rouprêt, Morgan, Seisen, Thomas   +8 more
core  

Evaluating an implementation strategy in cardiovascular prevention to improve prescribing of statins in Germany: an intention to treat analysis [PDF]

, 2013
BACKGROUND: The prescription of statins is an evidence-based treatment to reduce the risk of cardiovascular events in patients with elevated cardiovascular risk or with a cardiovascular disorder (CVD).
Baum, Erika, Becker, Annette, Donner-Banzhoff, Norbert, Hirsch, Oliver, Kaufmann-Kolle, Petra, Keller, Heidemarie, Krones, Tanja, Sönnichsen, Andreas C   +7 more
core   +1 more source

Rosuvastatin in Combination With Bortezomib Promotes Osteogenesis in Myeloma Bone Disease by Inhibiting the Secretion of CCL3

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu, Mingxu Hui, Fan Yang, Bo Huang, Nian Liu, Yuchan He, Xiaotao Wang   +6 more
wiley   +1 more source

Plasma Levels of Lathosterol and Phytosterols in Relation to Age, Sex, Anthropometric Parameters, Plasma Lipids and Apolipoprotein E Phenotype in 160 Dutch Families [PDF]

, 1991
In this study, the relation of plasma levels of lathosterol (an indicator of whole body cholesterol synthesis) and plant sterols (indicator of cholesterol absorption) with age, sex, weight, height, plasma lipids, and lipoproteins, and with apolipoprotein
Alberts, Assmann, Bjorkhem, Endo, Friedewald, Frishman, Goodman, Gylling, Havekes, Havel, Kempen, Kesaniemi, Lopes-Virella, Miettinen, Miettinen, Miettinen, Miettinen, Nestel, Palmer, Sing, Smit, Stasse-Wolthuis, Tilvis, Utermann   +23 more
core   +1 more source

Rethinking Statin Dosage in Coronary Disease

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Simon B. Dimmitt, Hans G. Stampfer, Michael C. Kennedy, Jennifer H. Martin   +3 more
wiley   +1 more source

Genetic Polymorphisms and Statin-Associated Side Effects: The Role of SLCO1B1 and Additional Risk Factors

Southeastern European Medical Journal
Statins are first-line agents for managing dyslipidemia, primarily prescribed to reduce low-density lipoprotein cholesterol (LDL-C) and prevent atherosclerotic cardiovascular disease (ASCVD).
Romana Marušić, Tatjana Bačun, Dunja Šojat, Saška Marczi   +3 more
doaj   +1 more source

Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors

The 1st International Electronic Conference on Clinical Medicine, 2021
Hélida Maravilha Dantas e Sousa Almeida, Igor de Sousa Oliveira, Sávio Benvindo Ferreira   +2 more
openaire   +1 more source