Results 81 to 90 of about 762,287 (195)

Prevalence of Statin Intolerance in a Primary Care Portuguese Population: A Retrospective Cohort Study

Journal of Lipid and Atherosclerosis
Objective We estimated the prevalence of statin intolerance (SI) in a Portuguese primary care population, applying the CLEAR Outcomes trial inclusion criteria. Methods This retrospective study analyzed electronic health records (EHRs) from the Local
Cristina Gavina, Francisco Araújo, Ana Rita Luz, Cristina Jácome, Jorge A. Ruivo, Carla Teixeira   +5 more
doaj   +1 more source

Efficacy and Safety of Moderate-Intensity Statin and Ezetimibe Combination Therapy Versus High-Intensity Statin Monotherapy in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Journal of Lipid and Atherosclerosis
Statins represent the first-line therapy for cholesterol management. However, for patients prone to statin side effects, unable to tolerate higher doses, or requiring additional low-density lipoprotein cholesterol (LDL-C) reduction, ezetimibe alone or in
Farah Yasmin, Abdul Moeed, Muhammad Umar, Farwa Zaidi, Maryam Sarwar Khan, M Chadi Alraies   +5 more
doaj   +1 more source

The overexpression and characterisation of Enoyl ACP Reductase from Brassica. napus: a component enzyme of fatty acid synthetase in plants [PDF]

, 1995
The main objective of this research is to advance our understanding at the structural and expressional level of plant enoyl ACP reductase (ER), the enzyme which catalyses the last reductive step in the de-novo biosynthesis of fatty acids.
Simon, Josiah William
core  

Mutations in SRD5B1 (AKR1D1), the gene encoding Delta(4)-3-oxosteroid 5 beta-reductase, in hepatitis and liver failure in infancy [PDF]

, 2003
Background: A substantial group of patients with cholestatic liver disease in infancy excrete, as the major urinary bile acids, the glycine and taurine conjugates of 7alpha-hydroxy-3-oxo-4-cholenoic acid and 7alpha, 12alpha-dihydroxy-3- oxo-4-cholenoic ...
Duran, M., Scambler, PJ, Custard, E. J., Bouquet, J, Lemonde, H. A., Clayton, P. T., Duran, M, Overmars, H, Bouquet, J., Scambler, P.J., Lemonde, H., Clayton, P.T., Custard, EJ, Scambler, P. J., Clayton, PT, Lemonde, HA, Custard, E.J., Overmars, H.   +17 more
core   +2 more sources

Statin Exposure Is Not Associated with Reduced Prevalence of Colorectal Neoplasia in Patients with Inflammatory Bowel Disease

Gut and Liver, 2019
Background/Aims Statins have been postulated to lower the risk of colorectal neoplasia. No studies have examined any possible chemopreventive effect of statins in patients with inflammatory bowel disease (IBD) undergoing colorectal cancer (CRC ...
Shailja C. Shah, Jason Glass, Gennaro Giustino, Joren R. ten Hove, Daniel Castaneda, Joana Torres, Akash Kumar, Jordan Elman, Thomas A. Ullman, Steven H. Itzkowitz   +9 more
doaj   +1 more source

Effects of exercise on the cognition of older women treated with lovastatin

Biomédica: revista del Instituto Nacional de Salud, 2018
Introduction: The deterioration of cognition is highly predominant in older adults. Objective: The aim of this study was to analyze the effects of a walking program on the cognition and blood concentration of lipids in women over 60 years of age who were
Edgardo Molina-Sotomayor, Rocío Arreguín-Moreno, Fernando Rodríguez-Rodríguez, Francisco Pradas, Juan Antonio León, José Antonio González-Jurado   +5 more
doaj   +1 more source

[Adverse drug reactions of hydroxymethylglutaryl-CoA reductase inhibitors reported to agency for medicinal products and medical devices].

Lijecnicki vjesnik, 2011
Hydroxymethylglutaryl-CoA reductase inhibitors (statins) are drugs used in the treatment of chronic diseases and frequently in concomitant therapy with many other drugs. Therefore, the risk of adverse drug reactions (ADRs), especially those caused by interactions is high.
Nikica Mirosević, Skvrce, Nada, Bozina, Viola Macolić, Sarinić, Sinisa, Tomić   +3 more
openaire   +1 more source

HMG-CoA Reductase Inhibitors Suppress High Glucose-induced Excessive O2⁻ production in J-774 Cells [PDF]

, 2003
Statins (HMG-CoA reductase inhibitors) have so-called pleiotropic effects, which directly reduce neoinitial inflammation of atherosclerosis, and one possible mechanism is the attenuation of oxidative stress.
Kase, Hiroyuki, Sato, Noriyuki, Kawagoe, Yoshiaki, Kato, Tetsuya, Suzuki, Manabu   +4 more
core  

High-Intensity Statin Therapy and Functional Independence after Acute Ischemic Stroke in Adults Aged 75 years and Older: A Retrospective, Single-Center Cohort Study [PDF]

Annals of Geriatric Medicine and Research
Background Older patients aged ≥75 years are underrepresented in major statin trials, leaving the optimal statin intensity after acute ischemic stroke (AIS) undefined.
Hyerim Choi, Eung-Joon Lee, Mee Jee Kim, Ga Hyun Kim, Shinwoong Kim, Namhee Kim, Jeong Yeon Seok, A Jeong Kim, Yun Hee Jo, Yoonsook Cho, Keun-Hwa Jung   +10 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults—Authors’ reply [PDF]

Clinical Microbiology and Infection, 2019
B, Pertzov, N, Eliakim-Raz, H, Atamna, A Z, Trestioreanu, D, Yahav, L, Leibovici   +5 more
openaire   +2 more sources