Results 111 to 120 of about 13,154 (208)

Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults—Authors’ reply [PDF]

Clinical Microbiology and Infection, 2019
B, Pertzov, N, Eliakim-Raz, H, Atamna, A Z, Trestioreanu, D, Yahav, L, Leibovici   +5 more
openaire   +2 more sources

Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients [PDF]

, 2017
Aims Statin therapy is associated with important benefits for patients at risk of, and with, established cardiovascular disease. There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if
Berwanger, Otavio, Briel, Matthias, Eyawo, Oghenowede, Mills, Edward J., Mills, Fergal, O'Regan, Christopher, Wu, Ping   +6 more
core  

Re: ‘Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults’ by Pertzov et al. [PDF]

Clinical Microbiology and Infection, 2019
X, Zhou, G, Tang
openaire   +2 more sources

Lipid management in patients newly referred to a vascular surgery outpatient clinic

JVS-Vascular Insights
Objective: To evaluate the lipid management of patients with atherosclerotic vascular disease at the time of first outpatient vascular surgery consult to identify potential opportunities for improved dyslipidemia pharmacotherapy and monitoring.
Martina Vergouwen, BN, Ali Bayrouti, BN, RN, Halli Krzyzaniak, BSc, MD, Paul F. Petrasek, MD, FRCSC   +3 more
doaj   +1 more source

Additive Effects of Ezetimibe and Statins in Managing Elevated LDL-C: An Approach to Reducing Cardiovascular Risk [PDF]

Journal of Advanced Biomedical Sciences
Elevated low-density lipoprotein cholesterol (LDL-C) is a key modifiable risk factor for cardiovascular disease. While statins are the cornerstone of LDL-C-lowering therapy, their long-term use may result in dose-dependent adverse effects.
Narges Yaghoobi, Mojtaba Farjam, Babak Pezeshki   +2 more
doaj  

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.

The Journal of biological chemistry, 2000
A novel human organic transporter, OATP2, has been identified that transports taurocholic acid, the adrenal androgen dehydroepiandrosterone sulfate, and thyroid hormone, as well as the hydroxymethylglutaryl-CoA reductase inhibitor, pravastatin. OATP2 is expressed exclusively in liver in contrast to all other known transporter subtypes that are found in
B, Hsiang, Y, Zhu, Z, Wang, Y, Wu, V, Sasseville, W P, Yang, T G, Kirchgessner   +6 more
openaire   +1 more source

Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury

Brazilian Journal of Cardiovascular Surgery
Objective: The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic ...
Carlos Henrique Marques dos Santos, Doroty Mesquita Dourado, Baldomero Antonio Kato da Silva, Henrique Budib Dorsa Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, Ian de Oliveira Chaves, João Victor Cunha Miranda, João Victor Durães Gomes Oliva, Letícia do Espírito Santo Dias, Murillo Henrique Martins de Almeida, Trícia Luna Sampaio   +11 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis

Cochrane Database of Systematic Reviews, 2014
Barak Pertzov, Anca Zalmanovici Trestioreanu, Noa Eliakim-Raz, Dafna Yahav, Leonard Leibovici   +4 more
openaire   +2 more sources

The Effect of Statins on Mortality in Septic Patients: a Meta-Analysis of Randomized Controlled Trials [PDF]

, 2013
OBJECTIVE: Statins are among the most prescribed drugs worldwide and their recently discovered anti-inflammatory effect seems to have an important role in inhibiting proinflammatory cytokine production, chemokines expression and counteracting the harmful
Belletti, A, Cabrini, L, Carozzo, A, Castro, ML, Chiesa, R, Feltracco, P, Finco, G, Landoni, G, Pasin, L, Zangrillo, A   +9 more
core  

Switching to rosuvastatin plus ezetimibe in statin-treated stroke patients with low-density lipoprotein cholesterol levels above 70 mg/dL (SWITCH): a prospective observational study

Lipids in Health and Disease
Background Effective lipid management is critical for secondary stroke prevention, however, many patients fail to achieve target low-density lipoprotein cholesterol (LDL-C) levels with statin monotherapy. This study evaluated the real-world effectiveness
Wookjin Yang, Yeong-Bae Lee, Eung-Gyu Kim, Han-Jin Cho, Sungwook Yu, Joon-Tae Kim, Jong Wook Shin, Soo Joo Lee, Beom Joon Kim, Ji Man Hong, Seong-Ho Koh, Sang Joon An, A-Hyun Cho, Jin-Man Jung, Hyun-Ji Cho, Chulho Kim, Eung-Joon Lee, Jeong-Min Kim, Seung-Hoon Lee   +18 more
doaj   +1 more source