Results 91 to 100 of about 1,232 (144)

HMGCR and Rosuvastatin Regulates GLP-1 Secretion and Expression-A Translational Study.

J Clin Endocrinol Metab
Miskelly MG, Lindqvist A, Jujić A, Hamilton A, Cowan E, Raikundalia S, Dutius Andersson AM, Nergård BJ, Del Giudice R, Kryvokhyzha D, Nilsson PM, Holst JJ, Torekov SS, Lagerstedt JO, Gomez MF, Eliasson L, Mulder H, Hedenbro J, Magnusson M, Wierup N.   +19 more
europepmc   +1 more source

PBX3-HMGCR Axis Promotes Hepatocellular Carcinoma Progression Through Enhancing De Novo Cholesterol Biosynthesis. [PDF]

Int J Mol Sci
Zhang X, Qiu L, Zhang L, Li W, Xiang D, Wang J, Wu S, Kasim V.   +7 more
europepmc   +1 more source

Cholesterol-lowering drug targets reduce risk of dementia: Mendelian randomization and meta-analyses of 1 million individuals. [PDF]

Alzheimers Dement
Nordestgaard LT, Hanson A, Sanderson E, Anderson E, Walker V, Tybjærg-Hansen A, Smith GD, Nordestgaard BG.   +7 more
europepmc   +1 more source

Targeting the mevalonate pathway enhances the efficacy of 5-fluorouracil by regulating pyroptosis. [PDF]

Med Oncol
Xing Z, Ma Y, Jiang X, Qing H, Wu Y, Che S, Gao Z, Wang K, Wang T, He Q, Li Z, Zhao B, Liu W, Sun H, Yu Z.   +14 more
europepmc   +1 more source

Drug Target Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Atrial Fibrillation.

Cardiology
Li F, Mei Y, Wu Q, Wu X.
europepmc   +1 more source

The regulation of hydroxymethylglutaryl-CoA reductase in cultured cells

Biochimica Et Biophysica Acta - Molecular Cell Research, 1988
Growth-stimulated synchronized cells exhibit a rapid increase in 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.88) activity prior to the onset of DNA synthesis. Under normal culture conditions, HMG-CoA reductase activity exhibits wide variations among experiments.
Fredric B Kraemer
exaly   +3 more sources

The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

Letters in Drug Design and Discovery, 2019
High cholesterol and triglyceride levels are mainly related to further generation of life-threating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
Hayrettin Ozan Gülcan, Serkan Yigitkan, İlkay Erdogan Orhan   +2 more
exaly   +4 more sources

Reversible modulation of liver hydroxymethylglutaryl CoA reductase

Life Sciences, 1978
Abstract The activity of rat liver microsomal hydroxymethylglutaryl CoA reductase (HMG CoA reductase, E.C. 1.1.1.34) is severely diminished when microsomes are preincubated with both ATP and Mg 2+ before the enzyme is assayed. Sensitivity to MgATP is progressively lost when microsomes are extracted with buffers.
D M, Gibson, T S, Ingebritsen
openaire   +2 more sources

Modulation of rat liver hydroxymethylglutaryl-CoA reductase by protein phosphatases: Purification of nonspecific hydroxymethylglutaryl-CoA reductase phosphatases

Archives of Biochemistry and Biophysics, 1985
Four phosphoprotein phosphatases, with the ability to act upon hydroxymethylglutaryl (HMG)-CoA reductase, phosphorylase, and glycogen synthase have been purified from rat liver cytosol through a process that involves DEAE-cellulose, aminohexyl-Sepharose-4B, and Bio-Gel A 1.5 m chromatographies.
V E, Calvet, G, Gil, F G, Hegardt
openaire   +2 more sources

Hydroxymethylglutaryl-CoA Reductase

1980
The reaction catalyzed by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [hydroxymethylglutaryl-CoA reductase (NADPH), EC 1.1.1.34] involves reductive deacylation of HMG-CoA to mevalonate and requires two moles of NADPH (Fig. 1).
W E, Brown, V W, Rodwell
openaire   +2 more sources