Results 111 to 120 of about 1,232 (144)
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1978
Hydroxymethylglutaryl-CoA reductase activity in fasting rats was almost doubled 12 h following a single dose (400 mg/kg) of the porphyrogenic chemical allylisopropylacetamide. This doubling effect of the drug on enzyme activity was observed during the basal period, as well as at midnight, when it is maximal in the diurnal rhythm. Cycloheximide, whether
A, Sanghvi, B, Parikh
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Hydroxymethylglutaryl-CoA reductase activity in fasting rats was almost doubled 12 h following a single dose (400 mg/kg) of the porphyrogenic chemical allylisopropylacetamide. This doubling effect of the drug on enzyme activity was observed during the basal period, as well as at midnight, when it is maximal in the diurnal rhythm. Cycloheximide, whether
A, Sanghvi, B, Parikh
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Pharmaceutical Research, 1994
In aqueous solutions, dalvastatin (1) undergoes epimerization as well as hydrolysis. The transformation of the drug was studied as a function of pH at 25 degrees C in aqueous solutions containing 20% acetonitrile. At all pH values, first-order plots for the conversion are biphasic, indicating rapid equilibration of 1 with its epimer (2) and slower ...
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In aqueous solutions, dalvastatin (1) undergoes epimerization as well as hydrolysis. The transformation of the drug was studied as a function of pH at 25 degrees C in aqueous solutions containing 20% acetonitrile. At all pH values, first-order plots for the conversion are biphasic, indicating rapid equilibration of 1 with its epimer (2) and slower ...
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Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.
Methods in enzymology, 1991Hydroxymethylglutaryl-CoA (HMG-CoA) reductase kinase has been previously assayed by its ability to inactivate HMG-CoA reductase in crude rat liver microsomes, using a radioisotopic assay for HMG-CoA reductase. However, this assay is insensitive and time consuming and it uses expensive radioisotopes and is subject to interference by HMG-CoA lyase and ...
Carling, D, Clarke, PR, Hardie, DG
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Hydroxymethylglutaryl-CoA reductase (NADPH)
1995Dietmar Schomburg, Dörte Stephan
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Regulation Of Cholesterol Synthesis By Hydroxymethylglutaryl Coa Reductase
Nutrition Reviews, 2009openaire +2 more sources
Bone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
2010ABSTRACT Objectives. The search of a non-toxic material to replace bone remains a big challenge for scientists. Previous studies examined more than 30 000 compounds from a collection of natural products and identified that statins, commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors (HMGRIs), increased expression of the morphogenetic ...
Rabie, ABM, Wong, RWK
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[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
1997Dietmar Schomburg, Dörte Stephan
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