Results 111 to 120 of about 1,236 (144)

Epimerization and Hydrolysis of Dalvastatin, a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor

Pharmaceutical Research, 1994
In aqueous solutions, dalvastatin (1) undergoes epimerization as well as hydrolysis. The transformation of the drug was studied as a function of pH at 25 degrees C in aqueous solutions containing 20% acetonitrile. At all pH values, first-order plots for the conversion are biphasic, indicating rapid equilibration of 1 with its epimer (2) and slower ...
openaire   +2 more sources

Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.

Methods in enzymology, 1991
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase kinase has been previously assayed by its ability to inactivate HMG-CoA reductase in crude rat liver microsomes, using a radioisotopic assay for HMG-CoA reductase. However, this assay is insensitive and time consuming and it uses expensive radioisotopes and is subject to interference by HMG-CoA lyase and ...
Carling, D, Clarke, PR, Hardie, DG
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Hydroxymethylglutaryl-CoA Reductase

2007
Sutherlin, A.L., Stauffacher, C.V., Bochar, D.A., Tabernero, L.; id_orcid 0000-0001-8867-455X, Hedl, M., Rodwell, V.W.   +5 more
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Hydroxymethylglutaryl-CoA reductase

1995
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Hydroxymethylglutaryl-CoA reductase (NADPH)

1995
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Regulation Of Cholesterol Synthesis By Hydroxymethylglutaryl Coa Reductase

Nutrition Reviews, 2009
openaire   +2 more sources

Characterization of hydroxymethylglutaryl-coa reductase in yeast

2021
openaire   +1 more source

Bone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

2010
ABSTRACT Objectives. The search of a non-toxic material to replace bone remains a big challenge for scientists. Previous studies examined more than 30 000 compounds from a collection of natural products and identified that statins, commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors (HMGRIs), increased expression of the morphogenetic ...
Rabie, ABM, Wong, RWK
openaire   +1 more source

[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

[Hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase

1991
Dietmar Schomburg, Margit Salzmann
openaire   +1 more source