Results 141 to 150 of about 80,142 (184)

Modulation of rat liver hydroxymethylglutaryl-CoA reductase by protein phosphatases: Purification of nonspecific hydroxymethylglutaryl-CoA reductase phosphatases

Archives of Biochemistry and Biophysics, 1985
Four phosphoprotein phosphatases, with the ability to act upon hydroxymethylglutaryl (HMG)-CoA reductase, phosphorylase, and glycogen synthase have been purified from rat liver cytosol through a process that involves DEAE-cellulose, aminohexyl-Sepharose-4B, and Bio-Gel A 1.5 m chromatographies.
V E, Calvet, G, Gil, F G, Hegardt
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Hydroxymethylglutaryl-CoA Reductase

1980
The reaction catalyzed by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [hydroxymethylglutaryl-CoA reductase (NADPH), EC 1.1.1.34] involves reductive deacylation of HMG-CoA to mevalonate and requires two moles of NADPH (Fig. 1).
W E, Brown, V W, Rodwell
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Role of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase 1 in nodule development of soybean

Journal of Plant Physiology, 2021
Autoregulation of nodulation (AON) plays a central role in nodulation by inhibiting the formation of excess number of legume root nodules. In this study, the effect of hydroxymethylglutaryl-coenzyme A reductase 1 (GmHMGR1) gene expression on nodulation and the AON system in Glycine max (L.) Merr was investigated.
Ali Izadi-Darbandi, Peter M. Gresshoff
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Saprophytic production of Clavine alkaloids and activity of Hydroxymethylglutaryl-CoA reductase

Folia Microbiologica, 1986
In submerged Claviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production and of sterol content. During the first alkaloid phase, cell mevalonate was involved in the biosynthesis of both alkaloids and steroids.
V, Kren, S, Pazoutová, V, Rylko, Z, Rehácek   +3 more
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Effect of Hydroxymethylglutaryl-CoA Reductase Inhibitors on the Functional Properties of Erythrocyte Membranes

Experimental and Molecular Pathology, 1993
We studied 56 patients affected by primary hypercholesterolemia treated with placebo for 1 month and with simvastatin (20 mg/day) or pravastatin (20 mg/day) for 6 months during a double-blind clinical trial. At 1-month intervals we determined the following parameters in the serum: total and HDL cholesterol, triglycerides, and apolipoprotein A-1 and B ...
R A, Rabini, M, Polenta, R, Staffolani, M, Tocchini, R, Signore, I, Testa, L, Mazzanti   +6 more
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Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast

Applied Microbiology and Biotechnology, 1998
The enzyme 3-hydroxy-3-methylglutaryl-co-enzyme-A (HMG-CoA) reductase is known as the rate limiting enzyme in early sterol biosynthesis in eukaryotic cells. To eliminate this regulation in the yeast Saccharomyces cerevisiae, a truncated HMG1 gene, producing a form of the enzyme that lacks the membrane-binding region (i.e.
T, Polakowski, U, Stahl, C, Lang
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Hydroxymethylglutaryl‐CoA reductase, a key enzyme in phytosterol synthesis?

Lipids, 1986
AbstractHydroxymethylglutaryl‐CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of isoprenoid compounds functional in plant cells, with phytosterols representing one class of major importance. Recently, it has shown possible to solubilize and purify the membrane‐bound enzyme from a heavy membrane fraction
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Tissue selectivity of hydroxymethylglutaryl coenzyme a (HMG CoA) reductase inhibitors

Pharmacology & Therapeutics, 1993
Hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors are a class of lipid-lowering medications, with a major activity on plasma cholesterol levels, now enjoying a vast popularity among physicians and patients. These drugs, affecting a very early and key step of sterol biosynthesis, differ to a large extent in their physicochemical properties,
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Stimulation of hydroxymethylglutaryl-CoA reductase activity after a single dose of the porphyrogenic chemical, allylisopropylacetamide

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1978
Hydroxymethylglutaryl-CoA reductase activity in fasting rats was almost doubled 12 h following a single dose (400 mg/kg) of the porphyrogenic chemical allylisopropylacetamide. This doubling effect of the drug on enzyme activity was observed during the basal period, as well as at midnight, when it is maximal in the diurnal rhythm. Cycloheximide, whether
A, Sanghvi, B, Parikh
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Molecular characterization of a hydroxymethylglutaryl-CoA reductase gene from mulberry (Morus alba L.)

Plant Molecular Biology, 2000
The genus Morus consists of trees and shrubs, which are distributed in temperate and subtropical regions. Commonly known as mulberry, a few of the Morus species are valued for their foliage, which constitutes the chief feed for mulberry silkworms. Steroids and isoprenoid compounds present in the foliage not only add nutritive factors to the feed but ...
A K, Jain, R M, Vincent, C L, Nessler
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