Results 131 to 140 of about 80,142 (184)

Genetic correlation between genes targeted by lipid-lowering drugs and venous thromboembolism: A drug-target Mendelian randomization study. [PDF]

Medicine (Baltimore)
Li M, Duan H, Luo J, Tan Y, Liu M, Zhao X, Shi D, Ma X.   +7 more
europepmc   +1 more source

Computational identification of epifriedelanol and derived analogs from Mikania cordata as potential HMG-CoA reductase inhibitors. [PDF]

PLoS One
Banu M, Ahmed SS, Begum M, Rahman MO.
europepmc   +1 more source

Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients. [PDF]

Sci Rep
Khaleqsefat E, Rasul KH, Kheder RK, Baban S, Baban J.   +4 more
europepmc   +1 more source

HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset. [PDF]

J Neurol
Díaz-Belloso R, Martín-Bornez M, Macías-García D, García-Díaz S, Bonilla-Toribio M, Buiza-Rueda D, Sánchez RP, Muñoz-Delgado L, Ojeda E, Jesús S, Adarmes-Gómez A, Carrillo F, Mir P, Gómez-Garre P.   +13 more
europepmc   +1 more source

HMGCR and Rosuvastatin Regulates GLP-1 Secretion and Expression-A Translational Study.

J Clin Endocrinol Metab
Miskelly MG, Lindqvist A, Jujić A, Hamilton A, Cowan E, Raikundalia S, Dutius Andersson AM, Nergård BJ, Del Giudice R, Kryvokhyzha D, Nilsson PM, Holst JJ, Torekov SS, Lagerstedt JO, Gomez MF, Eliasson L, Mulder H, Hedenbro J, Magnusson M, Wierup N.   +19 more
europepmc   +1 more source

Hydroxymethylglutaryl coA reductase (NADPH) in the latex of Hevea brasiliensis

Phytochemistry, 1982
Abstract The activity of hydroxymethylglutaryl CoA reductase (NADPH) (EC 1.1.1.34) was studied in the latex of regularly tapped mature trees of Hevea brasiliensis . The reductase activity was found mainly (95% of the total activity) in the pellet fraction (40 000 g ) of the centrifuged latex.
Abdullah B. Sipat, Sipat, Abdullah B.
exaly   +3 more sources

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The regulation of hydroxymethylglutaryl-CoA reductase in cultured cells

Biochimica Et Biophysica Acta - Molecular Cell Research, 1988
Growth-stimulated synchronized cells exhibit a rapid increase in 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.88) activity prior to the onset of DNA synthesis. Under normal culture conditions, HMG-CoA reductase activity exhibits wide variations among experiments.
Fredric Kraemer
exaly   +3 more sources

The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

Letters in Drug Design and Discovery, 2019
High cholesterol and triglyceride levels are mainly related to further generation of life-threating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
İlkay Erdogan Orhan, Hayrettin Gülcan, Serkan Yigitkan   +2 more
exaly   +4 more sources

The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage [PDF]

Pharmaceuticals, 2010
Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ...
Waisang Poon, George Kwok Chu Wong
exaly   +2 more sources

Reversible modulation of liver hydroxymethylglutaryl CoA reductase

Life Sciences, 1978
Abstract The activity of rat liver microsomal hydroxymethylglutaryl CoA reductase (HMG CoA reductase, E.C. 1.1.1.34) is severely diminished when microsomes are preincubated with both ATP and Mg 2+ before the enzyme is assayed. Sensitivity to MgATP is progressively lost when microsomes are extracted with buffers.
D M, Gibson, T S, Ingebritsen
openaire   +2 more sources