Results 131 to 140 of about 1,557 (185)

Clinicopathological features of anti-HMGCR and anti-SRP myopathies that do not satisfy the EULAR/ACR criteria of inflammatory myopathies. [PDF]

Rheumatology (Oxford)
Komaki S, Kubota A, Kitamura A, Maeda M, Kadoya M, Hokkoku K, Kobayashi S, Bannai T, Shiio Y, Uchio N, Uesaka Y, Kikuchi J, Sugimoto I, Mikata T, Okudera R, Suzuki K, Arai N, Sakiyama Y, Tokushige SI, Ichikawa Y, Yajima N, Nakashima R, Mimori T, Shimizu J, Komai T, Tsuchiya H, Fujio K, Toda T.   +27 more
europepmc   +1 more source

LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers: A Mendelian Randomization Study. [PDF]

Stroke
Dib MJ, Zagkos L, Meena D, Burgess S, Chirinos JA, Gill D.   +5 more
europepmc   +1 more source

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study. [PDF]

BMC Cancer
Li J, Yang Z, Wang T, Li M, Wu X, Fu X, Yang C, Li Y, Wang X, Lan Z, Li M, Chen S.   +11 more
europepmc   +1 more source

Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: drug target Mendelian randomization study. [PDF]

Lipids Health Dis
Jee Y, Shin JW, Ryu M, Song TJ.
europepmc   +1 more source

Pharmacophore Modeling and Binding Affinity of Secondary Metabolites from Angelica keiskei to HMG Co-A Reductase. [PDF]

Molecules
Aulifa DL, Amirah SR, Rahayu D, Megantara S, Muchtaridi M.   +4 more
europepmc   +1 more source

Drug Target Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Atrial Fibrillation.

Cardiology
Li F, Mei Y, Wu Q, Wu X.
europepmc   +1 more source

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Reversible modulation of liver hydroxymethylglutaryl CoA reductase

Life Sciences, 1978
Abstract The activity of rat liver microsomal hydroxymethylglutaryl CoA reductase (HMG CoA reductase, E.C. 1.1.1.34) is severely diminished when microsomes are preincubated with both ATP and Mg 2+ before the enzyme is assayed. Sensitivity to MgATP is progressively lost when microsomes are extracted with buffers.
D M, Gibson, T S, Ingebritsen
openaire   +4 more sources

The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

Letters in Drug Design & Discovery, 2019
High cholesterol and triglyceride levels are mainly related to further generation of lifethreating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
ERDOĞAN ORHAN, İLKAY, Gulcan, Hayrettin Ozan, Yigitkan, Serkan   +2 more
openaire   +4 more sources

Purification and properties of two native, high-molecular-weight hydroxymethylglutaryl-CoA reductase phosphatases

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
Abstract Using MgATP-inactivated rat liver microsomal hydroxymethylglutaryl-CoA reductase (reductase, EC 1.1.1.34) as substrate, we detected reductase phosphatase activity in liver tissue of several vertebrates. Rodent liver reductase phosphatase is primarily cytosolic but may have some affinity for membranes.
W E, Brown, V W, Rodwell
openaire   +4 more sources

Hydroxymethylglutaryl coA reductase (NADPH) in the latex of Hevea brasiliensis

Phytochemistry, 1982
Abstract The activity of hydroxymethylglutaryl CoA reductase (NADPH) (EC 1.1.1.34) was studied in the latex of regularly tapped mature trees of Hevea brasiliensis . The reductase activity was found mainly (95% of the total activity) in the pellet fraction (40 000 g ) of the centrifuged latex.
openaire   +3 more sources