Results 151 to 160 of about 1,557 (185)

Effects of pravastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, on two human tumour cell lines

Journal of Cancer Research and Clinical Oncology, 1995
Competitive inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase are currently used to treat patients with hypercholesterolaemia. These inhibitors affect not only cholesterol biosynthesis, but also the production of non-steroidal mevalonate derivatives, that are involved in a number of growth-regulatory processes.
A, Gebhardt, A, Niendorf
openaire   +2 more sources

Allosteric Activation of Rat Liver Microsomal [Hydroxymethylglutaryl-CoA Reductase (NADPH)]Kinase by Nucleoside Phosphates

Biological Chemistry Hoppe-Seyler, 1987
Microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase kinase activity is enhanced about 5 fold by 2 mM of either AMP or ADP. Activation constants, Ka, for AMP and ADP are 17 microM and 430 microM respectively, showing that AMP is a more potent activator than ADP.
A, Ferrer, C, Caelles, N, Massot, F G, Hegardt   +3 more
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Adenosine monophosphate-activated protein kinase: hydroxymethylglutaryl-CoA reductase kinase.

Methods in enzymology, 1991
Hydroxymethylglutaryl-CoA (HMG-CoA) reductase kinase has been previously assayed by its ability to inactivate HMG-CoA reductase in crude rat liver microsomes, using a radioisotopic assay for HMG-CoA reductase. However, this assay is insensitive and time consuming and it uses expensive radioisotopes and is subject to interference by HMG-CoA lyase and ...
Carling, D, Clarke, PR, Hardie, DG
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Epimerization and Hydrolysis of Dalvastatin, a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor

Pharmaceutical Research, 1994
In aqueous solutions, dalvastatin (1) undergoes epimerization as well as hydrolysis. The transformation of the drug was studied as a function of pH at 25 degrees C in aqueous solutions containing 20% acetonitrile. At all pH values, first-order plots for the conversion are biphasic, indicating rapid equilibration of 1 with its epimer (2) and slower ...
openaire   +2 more sources

Bone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

2010
ABSTRACT Objectives. The search of a non-toxic material to replace bone remains a big challenge for scientists. Previous studies examined more than 30 000 compounds from a collection of natural products and identified that statins, commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors (HMGRIs), increased expression of the morphogenetic ...
Rabie, ABM, Wong, RWK
openaire   +1 more source

Hydroxymethylglutaryl-CoA Reductase

2007
Sutherlin, A.L., Stauffacher, C.V., Bochar, D.A., Tabernero, L., Hedl, M., Rodwell, V.W.   +5 more
openaire   +3 more sources

The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors

High cholesterol and triglyceride levels are mainly related to further generation of life-threating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled.
Gulcan, Hayrettin Ozan, Yigitkan, Serkan, Orhan, Ilkay Erdogan   +2 more
openaire   +1 more source

Hydroxymethylglutaryl-CoA reductase

1995
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

Hydroxymethylglutaryl-CoA reductase (NADPH)

1995
Dietmar Schomburg, Dörte Stephan
openaire   +1 more source

[Hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase

1991
Dietmar Schomburg, Margit Salzmann
openaire   +1 more source