Results 171 to 180 of about 21,088 (210)

The regulation of hydroxymethylglutaryl-CoA reductase in cultured cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1988
Growth-stimulated synchronized cells exhibit a rapid increase in 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase, EC 1.1.1.88) activity prior to the onset of DNA synthesis. Under normal culture conditions, HMG-CoA reductase activity exhibits wide variations among experiments.
K Tavangar, Fredric B. Kraemer
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Hydroxymethylglutaryl‐CoA reductase, a key enzyme in phytosterol synthesis?

Lipids, 1986
AbstractHydroxymethylglutaryl‐CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of isoprenoid compounds functional in plant cells, with phytosterols representing one class of major importance. Recently, it has shown possible to solubilize and purify the membrane‐bound enzyme from a heavy membrane fraction
T. Bach
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Molecular characterization of a hydroxymethylglutaryl-CoA reductase gene from mulberry (Morus alba L.)

Plant Molecular Biology, 2000
The genus Morus consists of trees and shrubs, which are distributed in temperate and subtropical regions. Commonly known as mulberry, a few of the Morus species are valued for their foliage, which constitutes the chief feed for mulberry silkworms. Steroids and isoprenoid compounds present in the foliage not only add nutritive factors to the feed but ...
A K, Jain, R M, Vincent, C L, Nessler
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Allosteric Activation of Rat Liver Microsomal [Hydroxymethylglutaryl-CoA Reductase (NADPH)]Kinase by Nucleoside Phosphates

Biological Chemistry Hoppe-Seyler, 1987
Microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase kinase activity is enhanced about 5 fold by 2 mM of either AMP or ADP. Activation constants, Ka, for AMP and ADP are 17 microM and 430 microM respectively, showing that AMP is a more potent activator than ADP.
Albert Ferrer, Carmé Caelles, Nuria Massot, Fausto G. Hegardt   +3 more
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Hydroxymethylglutaryl-CoA reductase

Catalysis from A to Z, 1995
Dietmar Schomburg, Dörte Stephan
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Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults – A systematic review and meta-analysis

Clinical Microbiology and Infection, 2018
Barak Pertzov, Noa Eliakim‐Raz, Hani Atamna, Anca Zalmanovici Trestioreanu, Dafna Yahav, Leonard Leibovici   +5 more
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Regulation Of Cholesterol Synthesis By Hydroxymethylglutaryl Coa Reductase

Nutrition Reviews, 2009

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1α,25(OH)2D3 alleviates high glucose–induced lipid accumulation in rat renal tubular epithelial cells by inhibiting SREBPs

Journal of Cellular Biochemistry, 2019
Lipid accumulation is a vital event in the progression of diabetic nephropathy. 1,25‐Dihydroxyvitamin D3 (1α,25(OH)2D3) is considered to have a protective effect on diabetic nephropathy.
Miao Xu, Fei Jiang, Bingyan Li, Zengli Zhang   +3 more
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Reversible modulation of liver hydroxymethylglutaryl CoA reductase

Life Sciences, 1978
Abstract The activity of rat liver microsomal hydroxymethylglutaryl CoA reductase (HMG CoA reductase, E.C. 1.1.1.34) is severely diminished when microsomes are preincubated with both ATP and Mg 2+ before the enzyme is assayed. Sensitivity to MgATP is progressively lost when microsomes are extracted with buffers.
D M, Gibson, T S, Ingebritsen
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Modulation of rat liver hydroxymethylglutaryl-CoA reductase by protein phosphatases: Purification of nonspecific hydroxymethylglutaryl-CoA reductase phosphatases

Archives of Biochemistry and Biophysics, 1985
Four phosphoprotein phosphatases, with the ability to act upon hydroxymethylglutaryl (HMG)-CoA reductase, phosphorylase, and glycogen synthase have been purified from rat liver cytosol through a process that involves DEAE-cellulose, aminohexyl-Sepharose-4B, and Bio-Gel A 1.5 m chromatographies.
V E, Calvet, G, Gil, F G, Hegardt
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