Results 1 to 10 of about 74,894 (279)

Hydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial.

The Lancet Haematology, 2022
BACKGROUND In high-income countries, standard care for primary stroke prevention in children with sickle cell anaemia and abnormal transcranial Doppler velocities results in a 92% relative risk reduction of strokes but mandates initial monthly blood ...
S. Abdullahi, B. Jibir, H. Bello-Manga, S. Gambo, H. Inuwa, Aliyu Tijjani, Nura Idris, A. Galadanci, M. Hikima, Najibah A. Galadanci, A. Borodo, A. Tabari, Lawal Haliru, A. Suleiman, Jamil Ibrahim, B. C. Greene, D. Ghafuri, M. Rodeghier, J. Slaughter, F. Kirkham, K. Neville, A. Kassim, E. Trevathan, L. Jordan, M. Aliyu, M. DeBaun   +25 more
semanticscholar   +1 more source

Effect of treatment with hydroxyurea on calcium homeostasis in β-thalassemia-major patients

Al-Azhar Assiut Medical Journal, 2021
Background and aim Thalassemia is a chronic illness that has a range of serious clinical and psychological effects, it does not only affect the physical functioning of patients but also their emotional and social functioning and school functionings ...
Khaled H Hassan
doaj   +1 more source

Hydroxyurea

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2006
europepmc   +3 more sources

Hydroxyurea—The Good, the Bad and the Ugly

Genes, 2021
Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR) and as the agent that is commonly used to arrest cells in the S-phase of the cycle by inducing replication stress. It is a well-known and widely used drug, one which
Marcelina W Musiałek, D. Rybaczek
semanticscholar   +1 more source

Pregnancy outcomes with hydroxyurea use in women with sickle cell disease

American journal of hematology/oncology, 2022
Hydroxyurea reduces pain crises, acute chest syndrome, and blood transfusions in sickle cell disease (SCD), but potential detrimental effects on fertility and birth outcomes impede its use.
B. Kroner, J. Hankins, N. Pugh, A. Kutlar, A. King, N. Shah, J. Kanter, J. Glassberg, M. Treadwell, V. Gordeuk   +9 more
semanticscholar   +1 more source

A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic

Orphanet Journal of Rare Diseases, 2021
Background Hydroxyurea is one of the earliest drugs that showed promise in the management of haemoglobinopathies that include β-thalassaemia and sickle cell disease.
N. Yasara, A. Premawardhena, S. Mettananda   +2 more
semanticscholar   +1 more source

Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics‐guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia

British Journal of Haematology, 2021
Hydroxyurea (hydroxycarbamide) is an effective treatment for sickle cell anaemia (SCA), but clinical responses depend primarily upon the degree of fetal haemoglobin (HbF) induction and the heterogeneity of HbF expression across erythrocytes.
C. Quinn, O. Niss, M. Dong, A. Pfeiffer, Jennifer B Korpik, M. Reynaud, Holly Bonar, T. Kalfa, L. Smart, P. Malik, R. Ware, A. Vinks, Patrick T. McGann   +12 more
semanticscholar   +1 more source

Level of utilization and provider-related barriers to the use of hydroxyurea in the treatment of sickle cell disease patients in Jos, North-Central Nigeria

African Health Sciences, 2021
Background Hydroxyurea is underutilized by sickle cell health-care providers in Nigeria despite available evidence of its effectiveness in reducing the manifestations and complications of sickle cell disease (SCD).
Akinyemi O. D. Ofakunrin, E. Okpe, T. Afolaranmi, Rasaq R Olaosebikan, P. Kanhu, K. Adekola, N. Dami, A. Sagay   +7 more
semanticscholar   +1 more source

Apparent Stability Constant of Zr(Ⅳ)-Hydroxyurea Complex With pH Potentiometric Titration

He huaxue yu fangshe huaxue, 2022
Hydroxyurea(HU) is a reducing and complexing agent that can be used in the PUREX process. Zr is an important fission product in the spent fuel and main element of concern in the nuclear fuel reprocessing.
YANG Ya-ya, YANG Shu-ming, LI Ming-ming, LIU Xiao-juan, NIE Jiang, LAN Tian, XIAO Song-tao, OUYANG Ying-gen   +7 more
doaj   +1 more source

Absence of hydroxyurea‐induced mutational effects supports higher utilisation for the treatment of sickle cell anaemia

British Journal of Haematology, 2021
Hydroxyurea (hydroxycarbamide) is approved for treating both children and adults with sickle cell anaemia (SCA). Fetal haemoglobin (HbF) induction is the primary treatment response, along with improved anaemia, reduced haemolysis, myelosuppression and ...
R. Ware, Stephen D. Dertinger
semanticscholar   +1 more source