Results 131 to 140 of about 74,894 (279)

Hydroxyurea-Induced Erythroid Differentiation

Experimental Biology and Medicine, 1975
Hydroxyurea, a cytotoxic agent which destroys cells in DNA synthesis, has been shown to evoke the differentiation of a small number of hemopoietic precursor cells in the erythroid series of erythropoietically suppressed hypertransfused mice. This effect does not appear to be mediated by erythropoietin (EP) since the simultaneous injection of anti-EP ...
N J, Rencricca, B S, Morse, F C, Monette, D, Howard, F, Stohlman   +4 more
openaire   +2 more sources

Genetics and Genomics in Sickle Cell Disease in Africa

American Journal of Hematology, Volume 101, Issue S1, Page 47-55, April 2026.
ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya, Julie Makani, Jonathan M. Flanagan   +2 more
wiley   +1 more source

Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia [PDF]

, 2001
Chronic myeloid leukemia (CML) is characterized by formation of the BCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22.
Bench, AJ, Campbell, LJ, Grace, C, Green, AR, Huntly, BJP, Nacheva, EP, Prince, HM, Reid, AG, Shepherd, P, Szer, J, Telford, N, Turner, P   +11 more
core   +1 more source

Exploring Affordable Curative Therapy for Sickle Cell Disease in Africa: A Comprehensive Overview

American Journal of Hematology, Volume 101, Issue S1, Page 56-74, April 2026.
ABSTRACT The practical aspects of developing curative treatments for sickle cell disease (SCD) in Africa, such as gene therapy and hematopoietic stem cell transplantation, involve strengthening healthcare infrastructure, training healthcare professionals, establishing regional treatment centers, and creating national SCD programs.
Adetola A. Kassim, Alexis A. Thompson, Punam Malik   +2 more
wiley   +1 more source

Stroke burden and functional impacts in adults with sickle cell disease. [PDF]

Br J Haematol
Stroke was identified in 4.6% of 454 adults with sickle cell disease. Stroke occurred not only across HbSS/Sβ0 phenotypes but also HbSC/Sβ+ as well, challenging traditional assumptions. Stroke was associated with long‐term functional impairment, including cognitive deficits and higher disability scores.
St-Onge J, Hristova T, Charles C, Bereznyakova O, Jacquin G, Pouliot O, Caron-Lecuyer J, Stevanovik M, Desforges SM, Kazadi CM, Alejandro Rivillas J, Stapf C, Forté S.   +12 more
europepmc   +2 more sources

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library [PDF]

, 2019
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents
Collins, Eva-Maria S., Hagstrom, D., Tanguay, R., Truong, L., Zhang, S.   +4 more
core   +1 more source

The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]

, 2007
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton, al-Khodairy, Allshire, Allshire, Andrews, Apionishev, Branzei, Chakrabarti, Cheng, E.A. Outwin, Ekwall, F.-X. Ogi, F.Z. Watts, Grishchuk, Ho, Ho, Hoege, Hooker, J.C.-Y. Ho, Johnson, Kagey, Kahyo, L. Gardner, L.K. Boyd, M.A.M. Trickey, McDonald, Okubo, Pichler, Potts, Reindle, Sachdev, Schmidt, Sergeant, Shayeghi, Shin, Stelter, Strahl-Bolsinger, Tanaka, Taylor, Thon, Watts, Xhemalce, Xhemalce, Zhao, Zhao   +44 more
core   +2 more sources

Twenty Years of Therapeutic Leukocytapheresis in Newly Diagnosed Acute Myeloid Leukemia: Insights From A Single Center

Journal of Clinical Apheresis, Volume 41, Issue 2, April 2026.
ABSTRACT Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy, and 5%–20% of newly diagnosed patients present with hyperleukocytosis (HL). HL, most often defined as WBC > 100 000/μL, is a hematologic emergency associated with severe complications, early mortality, and poor prognosis, requiring immediate intervention.
Vojtech Latal, Ivana Skoumalova, Miroslava Palova, Tomas Szotkowski, Martin Cernan, Jana Navratilova, Helena Urbankova, Zuzana Pikalova, Ludek Raida, Edgar Faber, Tomas Papajik   +10 more
wiley   +1 more source

Hydroxyurea therapy in UK children with sickle cell anaemia: A single‐centre experience

Pediatric Blood & Cancer, 2018
Despite the demonstrated efficacy of hydroxyurea therapy, children with sickle cell anaemia in the UK are preferentially managed with supportive care or transfusion. Hydroxyurea is reserved for children with severe disease phenotype.
Kate Phillips, L. Healy, Louise Smith, R. Keenan   +3 more
semanticscholar   +1 more source

Global Burden of Sickle Cell Disease: Adequacy of Pain Control as Evidenced by Frequency of Oral Pain Medication Use, Health Outcomes, and Emotional Well‐Being Across Diverse Populations

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Sickle cell disease (SCD) is a chronic genetic disorder causing severe pain, anemia, and systemic complications that negatively affect patients’ physical and mental well‐being. The aim of this global cross‐sectional study was to evaluate the relationship between oral pain medication (OPM) use frequency and health outcomes ...
Akshat Jain, Lisa Roberts, Safiye Sahin
wiley   +1 more source