Results 201 to 210 of about 18,674 (285)

Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans. [PDF]

Nat Prod Bioprospect
Romussi S, Lacour A, Rayes D, De Rosa MJ.   +3 more
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Loss of function of chromatin remodeler OsCLSY4 leads to RdDM-mediated mis-expression of endosperm-specific genes affecting grain qualities. [PDF]

PLoS Genet
Pal AK, Rana S, Dey R, Shivaprasad PV.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Ubiquitination-Driven Reprogramming of Proteostasis in Metastasis. [PDF]

Adv Sci (Weinh)
Wei D, Chen J, Xu Y.
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

313 Manipulation of a pneumatic hyper-redundant actuator

The Proceedings of the Dynamics & Design Conference, 2010
Hisashi DATE, Yoshihiro TAKITA
openaire   +2 more sources

A hybrid learning framework integrating chaotic Niche alpha evolution for student academic performance prediction. [PDF]

Sci Rep
Chen H, Zhou Y, Cao Q.
europepmc   +1 more source

Hierarchical Differentiable Fluid Simulation

Computer Graphics Forum, EarlyView.
We introduce a two‐step algorithm that significantly reduces memory usage for solving control problems using differentiable fluid simulation techniques: our method first optimizes for bulk forces at reduced resolution, then refines local details over sub‐domains while maintaining differentiability. In trading runtime for memory, it enables optimization
Xiangyu Kong, Arnaud Schoentgen, Damien Rioux‐Lavoie, Paul G. Kry, Derek Nowrouzezahrai   +4 more
wiley   +1 more source

Optimizing feature selection with random reversal and adaptive Gaussian based Dung beetle optimizer for intrusion detection system in IoT. [PDF]

Sci Rep
Vurubindi P, Frnda J, Sujatha CN, Divakarachari PB, Nijaguna GS, Mahendar A.   +5 more
europepmc   +1 more source