ObjectivesThe aim of this study was to investigate an integrated diagnostics approach for prediction of the source of aldosterone overproduction in primary hyperaldosteronism (PA).Methods269 patients from the prospective German Conn Registry with PA were
Nabeel Mansour +18 more
doaj +1 more source
Hypokalemic rhabdomyolysis: a rare manifestation of primary aldosteronism [PDF]
Rhabdomyolysis is a rare presentation of hypokalemia, although muscle weakness is a well-known manifestation of hypokalemia. Primary aldosteronism is characterized by hypertension, suppressed plasma renin activity, increased aldosterone excretion and ...
CONCISTRE, ANTONIO +9 more
core
Inhibition of Galectin-3 Pathway Prevents Isoproterenol-Induced Left Ventricular Dysfunction and Fibrosis in Mice [PDF]
Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling. Previous evidence shows that Gal-3 interacts with aldosterone in promoting macrophage infiltration and vascular fibrosis and that Gal-3 genetic and ...
Cohen Solal, Alain +8 more
core +1 more source
Diabetic kidney disease, biomarkers, and finerenone
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley +1 more source
Adrenal Vein Sampling in Primary Aldosteronism: A Pictorial Essay for Optimal Left-Side Sampling
Primary aldosteronism (PA) is a curable cause of hypertension. Recent studies have revealed that the actual prevalence of PA is higher than previously recognized.
Gi Joo Kim +4 more
doaj +1 more source
Quantitative value of aldosterone-renin ratio for detection of aldosterone-producing adenoma: The Aldosterone-Renin Ratio for Primary Aldosteronism (AQUARR) study [PDF]
Background Current guidelines recommend use of the aldosterone\u2010renin ratio (ARR) for the case detection of primary aldosteronism followed by confirmatory tests to exclude false\u2010positive results from further diagnostic workup.
Andronico, Giuseppe +35 more
core +3 more sources
Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source
Rhabdomyolysis as first presentation of the Conn’s syndrome: a clinical case
Primary hyperaldosteronism is the leading cause of secondary hypertension, often presented with hypokalemia and even rare with its consequences. We describe a case of a 62-year-old man admitted to the emergency department with rhabdomyolysis from severe ...
Irida Kecaj +7 more
doaj +1 more source
Primary hyperaldosteronism among Chinese hypertensive patients: how are we doing in a local district in Hong Kong [PDF]
OBJECTIVES: To estimate the point prevalence of primary hyperaldosteronism in a government out-patient setting and to compare associated patient characteristics with those having essential hypertension.
Fu, SN +4 more
core
Hypertension - state of the art 2017 [PDF]
No abstract ...
McCallum, Linsay
core +1 more source

