Results 71 to 80 of about 15,128 (263)

Is It Possible to Screen for Primary Aldosteronism Effectively in Primary Care?

Clinical Endocrinology, Volume 103, Issue 2, Page 129-136, August 2025.
ABSTRACT Objective Primary aldosteronism (PA) is the commonest secondary cause of hypertension but case‐detection remains a challenge. Screening is usually performed in secondary care using an aldosterone:renin ratio (ARR) measurement. Here, we describe the outcomes of screening in primary care, in Oxfordshire, UK.
Harsha Anuruddhika Dissanayake, Bronwen Warner, Anne‐Marie Hannon, Riccardo Pofi, Radu Mihai, Tim James, Brian Shine, David William Ray, Jeremy W. Tomlinson, Aparna Pal   +9 more
wiley   +1 more source

Confounders of the aldosterone‐to‐renin ratio when used as a screening test in hypertensive patients: A critical analysis of the literature

The Journal of Clinical Hypertension, 2021
The aldosterone‐to‐renin ratio (ARR) is a common screening test for primary aldosteronism in hypertensives. However, there are many factors which could confound the ARR test result and reduce the accuracy of this test.
Gregory P. Veldhuizen, Rawan M. Alnazer, Abraham A. Kroon, Peter W. deLeeuw   +3 more
doaj   +1 more source

Inhibition of Galectin-3 Pathway Prevents Isoproterenol-Induced Left Ventricular Dysfunction and Fibrosis in Mice [PDF]

, 2016
Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling. Previous evidence shows that Gal-3 interacts with aldosterone in promoting macrophage infiltration and vascular fibrosis and that Gal-3 genetic and ...
Cohen Solal, Alain, Delcayre, Claude, EMDIN, MICHELE, Fazal, Loubina, Merval, Regine, PASSINO, Claudio, Prud’Homme, Mathilde, Samuel, Jane Lise, VERGARO, Giuseppe   +8 more
core   +1 more source

Cytological Assessment of Adrenal Tumours: Insights From 22‐Years Single Centre Experience

Clinical Endocrinology, Volume 103, Issue 2, Page 157-166, August 2025.
ABSTRACT Objective The incidence of adrenal tumours has increased in the last decades, mainly due to increased use of imaging. The diagnostic evaluation of adrenal masses can be complex and, in some cases, necessitates cytological evaluation. However, concerns remain regarding the potential complications associated with adrenal gland biopsy.
Ana Carasel, Jan Calissendorff, C. Christofer Juhlin, Henrik Falhammar   +3 more
wiley   +1 more source

Secondary hypertension as a cause of treatment resistance

Blood Pressure, 2023
In secondary hypertension, elevated blood pressure is caused by a known and/or potentially treatable underlying disease. Although the prevalence of secondary hypertension depends on the patient population and the thoroughness of applied diagnostic ...
Isabella Sudano, Paolo Suter, Felix Beuschlein   +2 more
doaj   +1 more source

Quantitative value of aldosterone-renin ratio for detection of aldosterone-producing adenoma: The Aldosterone-Renin Ratio for Primary Aldosteronism (AQUARR) study [PDF]

, 2017
Background Current guidelines recommend use of the aldosterone\u2010renin ratio (ARR) for the case detection of primary aldosteronism followed by confirmatory tests to exclude false\u2010positive results from further diagnostic workup.
Andronico, Giuseppe, Armanini, Decio, Belfiore, Anna, Bernini, Giampaolo, Bisogni, Valeria, Boscaro, Marco, Caliumi, Chiara, Cesari, Maurizio, Desideri, Giovambattista, Fabris, Bruno, Ferri, Claudio, Ganzaroli, Chiara, Ghigo, Ezio, Giacchetti, Gilberta, Letizia, Claudio, Maccario, Mauro, Maiolino, Giuseppe, Mallamaci, Francesca, Mannelli, Massimo, Mantero, Franco, Mattarello, Mee Yung, Moretti, Angelica, Opocher, Giuseppe, Palumbo, Gaetana, Parenti, Gabriele, Pessina, Achille Cesare, Plebani, Mario, Porteri, Enzo, Rizzoni, Damiano, Ronconi, Vanessa, Rossi, Ermanno, Rossi, Gian Paolo, Rossitto, Giacomo, Seccia, Teresa Maria, Semplicini, Andrea, Zoccali, Carmine   +35 more
core   +2 more sources

Phase Separation Regulates Metabolism, Mitochondria, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao, Peng Ding, Changqing Zhang, Junjie Gao   +3 more
wiley   +1 more source

LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal. [PDF]

, 2015
CONTEXT: Aldosterone synthesis and cellularity in the human adrenal zona glomerulosa (ZG) is sparse and patchy, presumably due to salt excess. The frequency of somatic mutations causing aldosterone-producing adenomas (APAs) may be a consequence of ...
Azizan, Elena AB, Bennett, Martin R, Brown, Morris J, Davenport, Anthony P, Figg, Nichola, Garg, Sumedha, Maguire, Janet J, McKenzie, Grahame, Neogi, Sudeshna Guha, Shaikh, Lalarukh Haris, Teo, Ada ED, Yeo, Giles S, Yu, Haixiang, Zhao, Wanfeng, Zhou, Junhua   +14 more
core   +3 more sources

Interleaved 23Na/1H MRI of the human heart at 7 T using a combined 23Na/1H coil setup and 1H parallel transmission

Magnetic Resonance in Medicine, Volume 94, Issue 1, Page 231-241, July 2025.
Abstract Purpose To evaluate the feasibility of interleaved 23Na/1H cardiac MRI at 7 T using 1H parallel transmission (pTx) pulses. Methods A combined setup consisting of a 23Na volume coil and two 1H transceiver arrays was employed and the transmit and receive characteristics were compared in vitro with those of the uncombined radiofrequency coils ...
Laurent Ruck, Nico Egger, Tobias Wilferth, Judith Schirmer, Lena Vanessa Gast, Sophia Nagelstraßer, Saskia Wildenberg, Andreas Bitz, Titus Lanz, Tanja Platt, Simon Konstandin, Christoph Kopp, Michael Uder, Armin Michael Nagel   +13 more
wiley   +1 more source

Tools to Predict Unilateral Primary Aldosteronism and Optimise Patient Selection for Adrenal Vein Sampling: A Systematic Review

Clinical Endocrinology, Volume 103, Issue 1, Page 3-12, July 2025.
ABSTRACT Objective Primary aldosteronism (PA), the most common endocrine cause of hypertension, is evaluated using adrenal vein sampling (AVS), to determine if aldosterone excess is bilateral or unilateral. AVS is invasive and technically challenging; it would ideally be used only in those with unilateral PA who are candidates for surgical cure.
Elisabeth Ng, Stella May Gwini, Winston Zheng, Peter J. Fuller, Jun Yang   +4 more
wiley   +1 more source