Results 41 to 50 of about 15,555 (178)
Mapping metabolic brain activity in three models of hepatic encephalopathy [PDF]
, 2013 Cirrhosis is a common disease in Western countries. Liver failure, hyperammonemia, and portal hypertension are the main factors that contribute to human cirrhosis that frequently leads to a neuropsychiatric disorder known as hepatic encephalopathy (HE ...
Aller Reyero, María Ángeles +5 more
core +3 more sources
Food Frontiers, Volume 7, Issue 2, March 2026.ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang +5 more
wiley +1 more source
Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension [PDF]
, 2016 BACKGROUND AND AIMS: Hepatic stellate cells (HSCs) are vital to hepatocellular function and the liver response to injury. They share a phenotypic homology with astrocytes that are central in the pathogenesis of hepatic encephalopathy, a condition in ...
Andreola, F +8 more
core +1 more source
Mitochondrial Dysfunction in Propionic Acidemia: A Case‐Report and Review of the Literature
JIMD Reports, Volume 67, Issue 2, March 2026.ABSTRACT Propionic acidemia is an inborn error of metabolism involving an enzymatic defect of propionyl‐CoA carboxylase that results in the build‐up of toxic metabolites which can induce metabolic decompensation. Secondary mitochondrial dysfunction in propionic acidemia has been commonly recognized; however, its clinical presentation and management are
Brandon K. Walther +5 more
wiley +1 more source
Hyperammonemia as a Marker of Subclinical Seizures After Traumatic Cardiac Arrest [PDF]
, 2016 This report details the presence of hyperammonemia in a patient who sustained cardiac arrest after a traumatic amputation. Serum ammonia levels may rise due to numerous etiologies; however, few reports detail its usefulness in diagnosing subclinical ...
Aswani, P., Kalina, M.
core +1 more source
Hyperammonemia in Hepatic Encephalopathy [PDF]
Journal of Clinical and Experimental Hepatology, 2018 The precise mechanism underlying the neurotoxicity of Hepatic Encephalopathy (HE) is remains unclear. The dominant view has been that gut-derived nitrogenous toxins are not extracted by the diseased liver and thereby enter the brain. Among the various toxins proposed, the case for ammonia is most compelling.
A R, Jayakumar, Michael D, Norenberg
openaire +2 more sources
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.Schematic workflow of the QSP model development and application. The study builds upon an initial adult male model structure (top left) by integrating reported data on age‐related changes in elimination pathways (top right). This allowed for the extension of the QSP model to pediatric and female populations (bottom right), which was then used to ...
Alejandra Schiavo +5 more
wiley +1 more source
Hepatic Failure: Role for biochemists and nutrition experts [PDF]
, 2002 Nutritional support to hepatic failure patients is challenging and requires experience, skill, careful planning and meticulous follow-up.
Rao Nanjunda, Mr Ananth
core +1 more source
Ammonia toxicity to the brain and creatine. [PDF]
, 2004 Symptoms of hyperammonemia are age-dependent and some are reversible. Multiple mechanisms are involved. Hyperammonemia increases the uptake of tryptophan into the brain by activation of the L-system carrier while brain glutamine plays a still undefined ...
Bachmann, C. +4 more
core +1 more source
Hyperammonemia in azotemic cats
Journal of Feline Medicine and Surgery, 2020 Objectives Hyperammonemia occurs in cats with hepatobiliary and nutritional (cobalamin and arginine deficiency) disorders, and has also been documented in four cats with renal azotemia. We hypothesized that in cats with renal azotemia, fasting hyperammonemia would correlate with indices of worsening kidney function, and would be independent of ...
Lauren Carvalho +3 more
openaire +2 more sources