Results 41 to 50 of about 19,505 (226)

The central role of hyperandrogenism in driving metabolic dysfunction in polycystic ovary syndrome: from pathophysiological mechanisms to targeted therapies

Journal of Ovarian Research
Polycystic ovary syndrome is a prevalent endocrine disorder wherein hyperandrogenism plays a central pathogenic role that extends beyond its reproductive manifestations.
Jinghui Xu, Bing He
doaj   +1 more source

Valproate-Induced Hyperandrogenism in Girls

Pediatric Neurology Briefs, 1999
The reproductive endocrine function in 41 girls, 8 to 18 years old, treated with valproate for epilepsy and in 54 healthy control girls was evaluated at the University of Oulu, Finland.
J Gordon Millichap
doaj   +1 more source

Efficacy and related factors of levonorgestrel‐releasing intrauterine system combined with metformin in fertility‐preserving treatment for atypical endometrial hyperplasia and early endometrial cancer: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu, Jialu Gao, Yuxin Li, Mei Huang, Xiaoshuang Wang, Xin Zhao   +5 more
wiley   +1 more source

Impact of ethnicity on the presentation of hyperandrogenism in polycystic ovarian syndrome:A review [PDF]

, 2020
Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. Diagnosis of PCOS is widely based on the 2003 Rotterdam criteria: Oligo-anovulation, hyperandrogenism and polycystic ovaries on ultrasound. However, clinical
Dominic, Nisha Angela, Chong, Annabel SL, Cheang, Hoi Lim, Arasoo, Valliammai Jayanthi T   +3 more
core   +3 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Evidence for Increased Expression of SIRT3 Associated with Hyperandrogenism in Granulosa Cells of Non-Obese PCOS Patients

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: SIRT3 regulates the generation of reactive oxygen species (ROS) in human granulosa cells (GCs). Increased levels of oxidative stress may cause follicular dysplasia in GCs of polycystic ovary syndrome (PCOS) patients.
Shen Zhang, Wenli Deng, Qiongyou Liu, Wei Yang   +3 more
doaj   +1 more source

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Women with polycystic ovary syndrome (PCOS) exhibit a substantially increased risk of miscarriage, yet the underlying mechanisms remain inadequately understood. This study aimed to investigate whether specific gut microbial dysbiosis and metabolic disturbance are associated with and may potentially contribute to endometrial ...
Mengyu Jing, Xi Chen, Meiyan Jiang, Huiya Fang, Xiaoming Zhu, Xuejing Jin, Yonghui Jiao, Ningning Hou, Weiwei Gong, Aixia Liu   +9 more
wiley   +1 more source

Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome [PDF]

, 2015
Introduction. Female hyperandrogenism is a frequent motive of consultation. It is revealed by hirsutism, acne or seborrhea, and disorders in menstruation cycle combined or not with virilisation signs.
A. Chadli, S. El Aziz, A. H. Dédjan, A. Farouqi   +3 more
core   +1 more source

Association of SNPs in the FK-506 binding protein (FKBP5) gene among Han Chinese women with polycystic ovary syndrome

BMC Medical Genomics, 2022
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, whose etiology remains uncertain, although it is known to be highly heterogeneous and genetically complex.
Xinyue Ma, Zhao Wang, Changming Zhang, Yuehong Bian, Xin Zhang, Xin Liu, Yongzhi Cao, Yueran Zhao   +7 more
doaj   +1 more source

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source