Results 141 to 150 of about 38,999 (275)

Ovariectomy, but not moderate intermittent hypoxia, promotes respiratory instability and risk of obesity in adult female rats

Experimental Physiology, EarlyView.
Abstract Sleep apnoea (SA) is a prevalent and complex respiratory disorder associated with recurrent interruptions of air flow during sleep. SA causes sleep fragmentation and intermittent hypoxia which leads to numerous negative health consequences.
Marianne Gagnon, Stéphanie Fournier, François Marcouiller, Natalie J. Michael, Vincent Joseph, Richard Kinkead   +5 more
wiley   +1 more source

Exogenous ketosis in breath‐hold diving: Promise, paradox and physiological risk

Experimental Physiology, EarlyView.
Abstract Exogenous ketosis induced by ketone ester (KE) ingestion has attracted growing interest as a potential strategy to enhance physiological tolerance to reduced O2 availability. Reported benefits arise largely from KE‐induced hyperventilation, which can improve systemic and tissue oxygenation during altitude exposure and hypoxic exercise ...
Ivan Drviš, Myrthe Stalmans, Dario Vrdoljak, Nikola Foretic, Damian M. Bailey, Željko Dujić   +5 more
wiley   +1 more source

Stimulus‐dependent sex differences in dyspnoea: Mechanical loading vs. hypercapnia

Experimental Physiology, EarlyView.
Abstract Dyspnoea is a multidimensional sensation of breathing discomfort that varies in sensory and affective experience. During exercise, healthy adults commonly report dyspnoea sensations of ‘air hunger’ and ‘work/effort’, with females more frequently reporting air hunger at maximal exertion.
Jack R. Dunsford, Olga Radivojevic, Olivia N. Ferguson, Alanna S. Hind, Michele R. Schaeffer, Owen D. Harris, Satvir S. Dhillon, Kathryn M. Milne, Dennis Jensen, Paolo B. Dominelli, Yannick Molgat‐Seon, Jordan A. Guenette   +11 more
wiley   +1 more source

The role of acid‐base balance in cerebrovascular and ventilatory responses to CO2 during 10 h normobaric hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend During 10 h exposures to normobaric hypoxia exposure there was a selective leftward shift in ventilatory response to hyperoxic hypercapnic rebreathing, but not the cerebrovascular response. The key findings are that the resetting of the central chemoreflex to lower PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$ during early hypoxic ...
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui‐Lin Fan   +3 more
wiley   +1 more source

Arterial–venous differences of brain‐derived neurotrophic factor isoforms across the brain and muscle after exercise at different intensities

The Journal of Physiology, EarlyView.
Abstract figure legend Exercise‐induced increases in forearm venous plasma and serum brain‐derived neurotrophic factor (BDNF) are often assumed to be indicative of release from the brain. Sixteen healthy and physically fit adults (20–40 years old) were recruited to investigate whether exercise‐induced changes in forearm venous mature BDNF (mBDNF) and ...
Olga Tarassova, Yiwen Jiang, Helena Wallin, Mats Jensen‐Urstad, Nikola Drca, Julia Röja, Marjan Pontén, Abram Katz, Jonna Nilsson, Maria M. Ekblom, Marcus Moberg   +10 more
wiley   +1 more source

Ventilatory and cerebrovascular responses to exercise in lowlander children acclimatizing to high‐altitude

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate age‐related differences in ventilatory and cerebrovascular responses to exercise at high‐altitude, adults (n = 10, 23–44 years) and children (n = 8, 7–14 years) completed progressive cycling exercise tests at sea‐level and following 6 days of acclimatization at 3800 m.
J. L. Koep, M. G. Rieger, K. J. Smith, G. R. DuManoir, C. M. Tallon, D. R. Perkins, S. Piombo, M. Stembridge, D. M. Cooper, S. Radom‐Aizik, P. N. Ainslie, A. M. McManus   +11 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Therapeutic hypercapnia after cardiac arrest: still promising or time to move on? [PDF]

Intensive Care Med Exp
Laosuksri W, Wittayachamnankul B, Chattipakorn SC, Chattipakorn N.   +3 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Neural circuitry mediating hypercapnia-induced microarousal and impaired sleep depth. [PDF]

Sci Adv
Yang C, Tang WX, Wang WX, Lv XL, Wang XY, He DN, Wen H, Guo JH, Zhou JX, Guan J, Cang J, Li SB.   +11 more
europepmc   +1 more source