Results 31 to 40 of about 38,036 (248)

Hypercapnia elicits differential vascular and blood flow responses in the cerebral circulation and active skeletal muscles in exercising humans

Physiological Reports, 2022
The purpose of this study was to investigate the effects of a rise in arterial carbon dioxide pressure (PaCO2) on vascular and blood flow responses in the cerebral circulation and active skeletal muscles during dynamic exercise in humans.
Shodai Moriyama, Masashi Ichinose, Kohei Dobashi, Ryoko Matsutake, Mizuki Sakamoto, Naoto Fujii, Takeshi Nishiyasu   +6 more
doaj   +1 more source

Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury

Frontiers in Physiology, 2022
Background and Objective: Lung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia.
Nada Ismaiel, Nada Ismaiel, Sara Whynot, Laurette Geldenhuys, Zhaolin Xu, Arthur S. Slutsky, Valerie Chappe, Dietrich Henzler, Dietrich Henzler   +8 more
doaj   +1 more source

Permissive hypercapnia

, 2001
The term permissive hypercapnia defines a ventilatory strategy for acute respiratory failure in which the lungs are ventilated with a low inspiratory volume and pressure.
Bigatello, Luca M., Patroniti, Nicoló, Sangalli, Fabio   +2 more
core   +1 more source

THE FOOTPRINT OF HYPERCAPNIA ON INFLAMMATORY PATHWAYS DURING BACTERIAL INFECTION

Open Respiratory Archives
Introduction: Pneumonia frequently occurs under hypercapnic conditions. Previous studies in hypercapnic models have reported that elevated CO2 levels inhibit the NF-κB pathway, resulting in reduced inflammation.
E. Campaña-Duel, A. Ceccato, A. Areny-Balagueró, V. Monforte, L. Blanch, L. Fernandez, A. Artigas, M. Camprubí-Rimblas   +7 more
doaj   +1 more source

Effect of chronic high-altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders. [PDF]

Exp Physiol
Abstract High‐altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular phenotype and the ophthalmological vascular response to CO2.
Paillisser A, Brugniaux JV, Berquet F, De Abreu J, Hogg S, Trucco E, Geiser M, Macgillivray T, Pichon A, Robach P, Champigneulle B, Verges S, Chiquet C.   +12 more
europepmc   +2 more sources

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, EarlyView.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

A retrospective study of the role of hypercapnia in patients with acromegaly

BMC Pulmonary Medicine, 2023
Background Acromegaly is a multisystemic disease characterized by an excessive release of growth hormone (GH) and insulin-like growth factor-1. Obstructive sleep apnea (OSA) is a common consequence of acromegaly, and hypercapnia is frequently observed in
Junwei Guo, Wenhao Cao, Jinmei Luo, Rong Huang, Yi Xiao   +4 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Regional venous outflow, blood volume, and sympathetic nerve activity during hypercapnia and hypoxic hypercapnia

, 1992
We examined the changes in systemic blood volume and regional venous outflow from the splanchnic, coronary, and other remaining vascular beds in response to acute hypercapnia or hypoxic hypercapnia in dogs, using cardiopulmonary bypass and a reservoir ...
Hiroyuki Arimura, Zeljko J. Bosnjak, Sumio Hoka, John P. Kampine   +3 more
core   +1 more source

CO2-dependent opening of an inwardly rectifying K+ channel [PDF]

, 2011
CO2 chemosensing is a vital function for the maintenance of life that helps to control acid–base balance. Most studies have reported that CO2 is measured via its proxy, pH. Here we report an inwardly rectifying channel, in outside-out excised patches
Dale, Nicholas, Robert T. R. Huckstepp, Huckstepp, Robert T. R., Nicholas Dale   +3 more
core   +1 more source