Results 21 to 30 of about 27,845 (231)

Hypercapnia as a preventative therapeutic strategy: Unveiling the neuroprotective potential and mechanisms

Brain Disorders
Hypercapnia, an increase in carbon dioxide (CO2) in the bloodstream, has been historically considered purely a pathological condition. However, based on several publications evaluating the adverse outcome of certain conditions with an additional ...
K. Fazeli, S.B. Jameie, M. Farhadi
doaj   +1 more source

Adaptation of Respiratory-Related Brain Regions to Long-Term Hypercapnia: Focus on Neuropeptides in the RTN

Frontiers in Neuroscience, 2019
Long-term hypercapnia is associated with respiratory conditions including obstructive sleep apnea, chronic obstructive pulmonary disease and obesity hypoventilation syndrome.
Ayse Sumeyra Dereli, Zarwa Yaseen, Pascal Carrive, Natasha N. Kumar   +3 more
doaj   +1 more source

Hypercapnia elicits differential vascular and blood flow responses in the cerebral circulation and active skeletal muscles in exercising humans

Physiological Reports, 2022
The purpose of this study was to investigate the effects of a rise in arterial carbon dioxide pressure (PaCO2) on vascular and blood flow responses in the cerebral circulation and active skeletal muscles during dynamic exercise in humans.
Shodai Moriyama, Masashi Ichinose, Kohei Dobashi, Ryoko Matsutake, Mizuki Sakamoto, Naoto Fujii, Takeshi Nishiyasu   +6 more
doaj   +1 more source

The role of hypercapnia in acute respiratory failure

Intensive Care Medicine Experimental, 2019
The biological effects and physiological consequences of hypercapnia are increasingly understood. The literature on hypercapnia is confusing, and at times contradictory.
Luis Morales-Quinteros, Marta Camprubí-Rimblas, Josep Bringué, Lieuwe D. Bos, Marcus J. Schultz, Antonio Artigas   +5 more
doaj   +1 more source

Effect of mild hypercapnia during the recovery period on the emergence time from total intravenous anesthesia: a randomized controlled trial [PDF]

Korean Journal of Anesthesiology
Background Intraoperative hypercapnia reduces the time to emergence from volatile anesthetics, but few clinical studies have explored the effect of hypercapnia on the emergence time from intravenous (IV) anesthesia. We investigated the effect of inducing
Lan Liu, Xiangde Chen, Qingjuan Chen, Xiuyi Lu, Lili Fang, Jinxuan Ren, Yue Ming, Dawei Sun, Pei Chen, Weidong Wu, Lina Yu   +10 more
doaj   +1 more source

Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury

Frontiers in Physiology, 2022
Background and Objective: Lung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia.
Nada Ismaiel, Nada Ismaiel, Sara Whynot, Laurette Geldenhuys, Zhaolin Xu, Arthur S. Slutsky, Valerie Chappe, Dietrich Henzler, Dietrich Henzler   +8 more
doaj   +1 more source

Effects of Acute Systemic Hypoxia and Hypercapnia on Brain Damage in a Rat Model of Hypoxia-Ischemia. [PDF]

PLoS ONE, 2016
Therapeutic hypercapnia has the potential for neuroprotection after global cerebral ischemia. Here we further investigated the effects of different degrees of acute systemic hypoxia in combination with hypercapnia on brain damage in a rat model of ...
Wanchao Yang, Xuezhong Zhang, Nan Wang, Jing Tan, Xianhai Fang, Qi Wang, Tao Tao, Wenzhi Li   +7 more
doaj   +1 more source

THE FOOTPRINT OF HYPERCAPNIA ON INFLAMMATORY PATHWAYS DURING BACTERIAL INFECTION

Open Respiratory Archives
Introduction: Pneumonia frequently occurs under hypercapnic conditions. Previous studies in hypercapnic models have reported that elevated CO2 levels inhibit the NF-κB pathway, resulting in reduced inflammation.
E. Campaña-Duel, A. Ceccato, A. Areny-Balagueró, V. Monforte, L. Blanch, L. Fernandez, A. Artigas, M. Camprubí-Rimblas   +7 more
doaj   +1 more source

A retrospective study of the role of hypercapnia in patients with acromegaly

BMC Pulmonary Medicine, 2023
Background Acromegaly is a multisystemic disease characterized by an excessive release of growth hormone (GH) and insulin-like growth factor-1. Obstructive sleep apnea (OSA) is a common consequence of acromegaly, and hypercapnia is frequently observed in
Junwei Guo, Wenhao Cao, Jinmei Luo, Rong Huang, Yi Xiao   +4 more
doaj   +1 more source

Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats

Epilepsia, EarlyView.
Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire, Elise Collard, Abigail Niyibizi, Natasha N. Kumar, Enrique Germany Morrison, Javier Chavez Cerda, Ayse S. Dereli, Riem El Tahry   +7 more
wiley   +1 more source