Results 11 to 20 of about 38,999 (275)

Permissive hypercapnia

Current Opinion in Critical Care, 2001
The term permissive hypercapnia defines a ventilatory strategy for acute respiratory failure in which the lungs are ventilated with a low inspiratory volume and pressure. The aim of permissive hypercapnia is to minimize lung damage during mechanical ventilation; its limitation is the resulting hypoventilation and carbon dioxide (CO2) retention. In this
Bigatello, Luca M., Patroniti, Nicoló, Sangalli, Fabio   +2 more
openaire   +4 more sources

Hypercapnia as a preventative therapeutic strategy: Unveiling the neuroprotective potential and mechanisms

Brain Disorders
Hypercapnia, an increase in carbon dioxide (CO2) in the bloodstream, has been historically considered purely a pathological condition. However, based on several publications evaluating the adverse outcome of certain conditions with an additional ...
K. Fazeli, S.B. Jameie, M. Farhadi
doaj   +2 more sources

Rapamycin improves satellite cells’ autophagy and muscle regeneration during hypercapnia

JCI Insight
Both CO2 retention, or hypercapnia, and skeletal muscle dysfunction predict higher mortality in critically ill patients. Mechanistically, muscle injury and reduced myogenesis contribute to critical illness myopathy, and while hypercapnia causes muscle ...
Joseph Balnis, Emily L. Jackson, Lisa A. Drake, Diane V. Singer, Ramon Bossardi Ramos, Harold A. Singer, Ariel Jaitovich   +6 more
doaj   +2 more sources

Study on prevention of hypercapnia by Nasal High Flow in patients with endoscopic submucosal dissection during intravenous anesthesia [PDF]

, 2020
BACKGROUND: For relatively invasive upper gastrointestinal endoscopy procedures, such as an endoscopic submucosal dissection (ESD), intravenous anesthesia is routinely used to reduce patient anxiety. However, with the use of intravenous sedation, even at
Hashiguchi, Keiichi, Yamguchi, Naoyuki, Nakao, Kazuhiko, Mishima, Gaku, Nakashima, Sawako, Ayuse, Takao, Hosogaya, Naoki, Sanuki, Takuro, Tatkov, Stanislav, Kurata, Shinji, Pinkham, Max   +10 more
core   +1 more source

Study on prevention of hypercapnia by nasal high flow in patients undergoing endoscopic retrograde cholangiopancreatography during intravenous anesthesia [PDF]

, 2020
BACKGROUND: For relatively invasive upper gastrointestinal endoscopy procedures, such as an endoscopic retrograde cholangiopancreatography (ERCP), and also lower gastrointestinal endoscopy procedures, intravenous anesthesia is routinely used to reduce ...
Nagata, Kazuyoshi, Kazuhiko, Nakao, Mishima, Gaku, Sawase, Hironori, Komatsu, Naohiro, Hosogaya, Naoki, Kurata, Shinji, Nakashima, Sawako, Ayuse, Takao, Ozawa, Eisuke, Sanuki, Takuro, Tatkov, Stanislav, Pinkham, Max   +12 more
core   +1 more source

Hypercapnia enhances airway smooth muscle contractility via STIM1-dependent Ca2+ signaling. [PDF]

JCI Insight
Hypercapnia, elevated carbon dioxide (CO 2 ), is common in advanced chronic obstructive pulmonary disease (COPD) and predicts poor clinical outcomes.
Shigemura M, Kryvenko V, Pacheco JA, Puckelwartz MJ, Aleksic M, Magnani ND, Thompson E, Martin-Romero FJ, Cummins EP, Seeger W, Bräuninger A, Welch LC, Budinger GRS, Lecuona E, Dada LA, Bharat A, Vadász I, Prakriya M, Sznajder JI.   +18 more
europepmc   +2 more sources

Effects of hypercapnia on the lung [PDF]

The Journal of Physiology, 2017
AbstractGases are sensed by lung cells and can activate specific intracellular signalling pathways, and thus have physiological and pathophysiological effects. Carbon dioxide (CO2), a primary product of oxidative metabolism, can be sensed by eukaryotic cells eliciting specific responses via recently identified signalling pathways.
Masahiko Shigemura, Emilia Lecuona, Jacob I. Sznajder   +2 more
openaire   +2 more sources

Hemodynamic Effects of Prolonged Apneic Oxygenation in Laryngologic Surgery: A Randomized Controlled Pilot Trial. [PDF]

World J Otorhinolaryngol Head Neck Surg
ABSTRACT Background Limited data exist on cardiocirculatory responses associated with extended periods of apnea during administration of high‐flow nasal oxygen for laryngologic surgery (apneic oxygenation with HFNO, AO‐HFNO). The possibility of hemodynamic compromise in the settings of acute hypercapnia, respiratory acidosis, hyperoxia, and IV ...
Nekhendzy V, Lemmens HJ, Saxena AR, Mittal BM, Damrose EJ, Sung CK, Bowen R.   +6 more
europepmc   +2 more sources

Graded Hypercapnia-Calibrated BOLD: Beyond the Iso-metabolic Hypercapnic Assumption

Frontiers in Neuroscience, 2017
Calibrated BOLD is a promising technique that overcomes the sensitivity of conventional fMRI to the cerebrovascular state; measuring either the basal level, or the task-induced response of cerebral metabolic rate of oxygen consumption (CMRO2).
Ian D. Driver, Richard G. Wise, Kevin Murphy, Kevin Murphy   +3 more
doaj   +1 more source

Therapeutic hypercapnia for prevention of secondary ischemia after severe subarachnoid hemorrhage: physiological responses to continuous hypercapnia

Scientific Reports, 2021
Temporary hypercapnia has been shown to increase cerebral blood flow (CBF) and might be used as a therapeutical tool in patients with severe subarachnoid hemorrhage (SAH).
Christian Stetter, Franziska Weidner, Nadine Lilla, Judith Weiland, Ekkehard Kunze, Ralf-Ingo Ernestus, Ralf Michael Muellenbach, Thomas Westermaier   +7 more
doaj   +1 more source