Laboratory Identification of Pseudohypercalcemia Induced by Hyperglobulinemia in Multiple Myeloma: A Case Report [PDF]
Journal of Clinical Laboratory Analysis, EarlyView.Pseudohypercalcemia induced by calcium‐binding monoclonal immunoglobulin in multiple myeloma is verified via laboratory assays and validated by therapeutic response. ABSTRACT Background Pseudohypercalcemia is easily misdiagnosed in clinical practice, potentially leading to unnecessary interventions.
Anjiang Zhao +3 more
wiley +2 more sources
Hypergammaglobulinemia in treated and untreated people with HIV. [PDF]
PLoS ONEBackgroundB cell abnormalities are an early feature of human immunodeficiency virus-1 (HIV) infection, leading to hypergammaglobulinemia.Objective(s)The aim of this study was to evaluate serum levels of immunoglobulin G (IgG) as well as the inflammatory ...
Isabel Vigmo +5 more
doaj +3 more sources
Prognostic benefit of immunosuppressive agents in primary Sjögren’s syndrome patients with hypergammaglobulinemia [PDF]
Frontiers in ImmunologyObjectiveTo elucidate the prognosis of patients with primary Sjögren’s syndrome (pSS) accompanied by hypergammaglobulinemia (HG), with a particular focus on the impact of various treatments.MethodsPatients were divided into the HG group and the non-HG ...
Liupan Zhang +8 more
doaj +2 more sources
PLoS ONE, 2019 As debate rumbles on about whether anti-hepatitis B virus (HBV) nucleos(t)ide analogue treatments modulate host immune system during end-stage liver diseases, we studied effects of two potent anti-HBV agents, telbivudine or entecavir, on humoral immune ...
Cheng-Hsun Ho +2 more
doaj +2 more sources
Impact of Sjögren’s disease and its immunological characteristics on reaching remission or low disease activity state in systemic lupus erythematosus patients: a propensity score-matched longitudinal study [PDF]
Frontiers in ImmunologyBackgroundSystemic lupus erythematosus (SLE) overlapping with Sjögren’s disease (SjD) or not may progress differently in the clinical course. We aimed to explore the impact of SjD on lupus low disease activity state (LLDAS) or remission achievement in a ...
Haoze Zhang +5 more
doaj +2 more sources
Early-onset systemic lupus erythematosus in a patient with an inborn error of immunity caused by a NRAS mutation and treated with telitacicept [PDF]
Molecular and Cellular PediatricsHere, we report a female (aged 1 year and 8 months) who presented with recurrent skin lesions, hepatosplenomegaly, lymphadenopathy, and fever.
Zhijuan Kang, Liang Zhang
doaj +2 more sources
Journal of Pediatric and Neonatal Individualized Medicine, 2014 CNS (Congenital nephrotic syndrome) is a disorder characterized by the presence of a nephrotic syndrome in the first three months of life. Different pathologies can cause this syndrome.
Claudia Fanni +5 more
doaj +1 more source
Features and outcome of AIH patients without elevation of IgG
JHEP Reports, 2020 Background & Aims: High IgG levels are considered a hallmark of autoimmune hepatitis (AIH). A subgroup of patients with AIH has IgG within the normal range despite evidence of clinical disease activity. The clinical significance of this biomarker has
Johannes Hartl +17 more
doaj +1 more source
Interferon as a macrophage activating factor. I. Enhancement of cytotoxicity by fresh and matured human monocytes in the absence of other soluble signals [PDF]
, 1983 The cytolytic activity ofhuman peripheral blood monocytes in vitro against K-562 human leukaemic target cells was stimulated by human fibroblast (fi-) and leucocyte (a-) interferon (IFN). Stimulation was by up to several times the corresponding control
Virelizier, JL, Dean, RT
core +7 more sources
Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study [PDF]
, 2014 Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established.
Sundel, Robert +3 more
core +1 more source