Results 11 to 20 of about 4,003 (221)

A Case of Gastric Neuroendocrine Tumor With a Raspberry-Like Appearance on the Background of Acid-Suppressive Therapy-Related Gastropathy. [PDF]

DEN Open
ABSTRACT We report the case of a 52‐year old man who was referred to our institution after a routine health check identified an asymptomatic gastric polyp. The medical history of the patient included reflux esophagitis, for which he had been treated with vonoprazan 10 mg daily for 6 years after initially receiving proton pump inhibitors.
Moriguchi Y, Nakahodo J, Iseki M, Funabiki T, Oka Y, Noma E, Arakawa T, Horiguchi SI, Goto O, Iizuka T.   +9 more
europepmc   +2 more sources

Safety of Potassium-Competitive Acid Blockers Compared With Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease and Peptic Ulcer Disease: A Systematic Review and Meta-Analysis. [PDF]

J Gastroenterol Hepatol
ABSTRACT Background and Aim Potassium‐competitive acid blockers (P‐CABs) are a novel class of acid suppressants developed to overcome the limitations of proton pump inhibitors (PPIs), providing rapid and sustained acid suppression. While PPI‐related adverse events (AEs) are well‐documented, safety data on P‐CABs remain limited.
Jang Y, Park J, Kang D, Kim JH, Choi HS, Jeon HL, Lee H.   +6 more
europepmc   +2 more sources

Hypergastrinemia Expands Gastric ECL Cells Through CCK2R+ Progenitor Cells via ERK ActivationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Enterochromaffin-like (ECL) cells in the stomach express gastrin/cholecystokinin 2 receptor CCK2R and are known to expand under hypergastrinemia, but whether this results from expansion of existing ECL cells or increased production
Weiwei Sheng, Ermanno Malagola, Henrik Nienhüser, Zhengyu Zhang, Woosook Kim, Leah Zamechek, Antonia Sepulveda, Masahiro Hata, Yoku Hayakawa, Chun-Mei Zhao, Duan Chen, Timothy C. Wang   +11 more
doaj   +1 more source

Gastrin: From Physiology to Gastrointestinal Malignancies

Function, 2022
Abetted by widespread usage of acid-suppressing proton pump inhibitors (PPIs), the mitogenic actions of the peptide hormone gastrin are being revisited as a recurring theme in various gastrointestinal (GI) malignancies.
Suzann Duan, Karen Rico, Juanita L Merchant   +2 more
doaj   +1 more source

Is an optimization of the use of proton pump inhibitors feasible in the real world medical practice?

Alʹmanah Kliničeskoj Mediciny, 2023
The review deals with the data on negative health impact of prolonged and inadequate use of proton pump inhibitors (PPI). Since their advent at the end of 1980s, their worldwide use has been continuously increasing.
Natalia M. Khomeriki, Sergey G. Khomeriki   +1 more
doaj   +1 more source

Somatostatin receptor molecular imaging in a misdiagnosed gastrinoma case

World Journal of Nuclear Medicine, 2020
Gastrin-secreting tumors, hypergastrinemia and severe ulcer disease form the trademarks of Zollinger-Ellison syndrome (ZES). We report a case of gastrinoma, in a patient who was misdiagnosed for almost five years.
Cati Stolniceanu, Irena Grierosu, Milovan Matovic, Cipriana Stefanescu   +3 more
doaj   +1 more source

Evaluation of the effects of medium‐term (57‐day) omeprazole administration and of omeprazole discontinuation on serum gastrin and serum chromogranin A concentrations in the horse

Journal of Veterinary Internal Medicine, 2023
Background Rebound gastric hyperacidity (RGH) secondary to hypergastrinemia has been suggested to contribute to the rapid recurrence of equine squamous gastric disease (ESGD) in horses after discontinuation of omeprazole.
Bethanie Clark, Catherine Steel, Jessica Vokes, Jack R. Shan, Kristene Gedye, Amy Lovett, B. W. Sykes   +6 more
doaj   +1 more source

Do Gastric Signet Ring Cell Carcinomas and ECL-Cell Neuroendocrine Tumours Have a Common Origin?

Medicina, 2022
Gastric cancer is a heterogenous group of tumours, and a better understanding of the carcinogenesis and cellular origin of the various sub-types could affect prevention and future treatment.
Reidar Fossmark, Rune Johannessen, Gunnar Qvigstad, Patricia Mjønes   +3 more
doaj   +1 more source

Esophageal Perforation in Zollinger-Ellison Syndrome: A Scoping Review of Management and Outcomes. [PDF]

JGH Open
ABSTRACT Esophageal perforation in Zollinger–Ellison syndrome (ZES) is an exceedingly rare and life‐threatening manifestation of gastrinoma‐related acid hypersecretion. While peptic ulceration and severe reflux are recognized complications of ZES, perforation represents the ultimate consequence of uncontrolled hyperacidity. Evidence remains confined to
Fernicola A, Parmeggiani D, Crocetto F, Calogero A, Cece A, Romano D, Benassai G, Quarto G, Santangelo M.   +8 more
europepmc   +2 more sources

The Role of Pepsinogenes and Some Intestinal Hormones in Pathogenesis of Gastroesophageal Reflux Disease [PDF]

, 2018
80 patients with gastroesophageal reflux disease (GERD) were examined. The diagnosis of GERD was based on the history of the disease, complaints of patients, the results of daily monitoring of pH in the lower third of the esophagus, data of ...
Boichuk, V. (Vira)
core   +2 more sources