Results 161 to 170 of about 38,229 (306)

OCT‐2 Is Associated With Pro‐Metastatic Epigenomic Properties of Triple‐Negative Breast Cancer Cells

open access: yesCancer Science, EarlyView.
The transcription factor OCT‐2 (encoded by POU2F2) is involved in the formation of super‐enhancers (SEs) in triple‐negative breast cancer (TNBC) cells. Overexpression of POU2F2 enhances the metastasis of TNBC cells in mice, and their expression is highly correlated to the poor prognosis of TNBC patients. ABSTRACT Triple‐negative breast cancer (TNBC) is
Kazuki Ogikubo   +7 more
wiley   +1 more source

Motor performance and higher associative cortical networks in adolescents with neonatal hypoxic‐ischaemic encephalopathy treated with therapeutic hypothermia

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Several functional connections between ROIs in the somatomotor (purple) and the default mode network (gray) were significantly associated with the MABC‐2 “aiming and catching” sub‐domain in the HIE cohort in comparison to controls. The colors of the connections represents the correlation coefficient with either negative (light blue to magenta) or ...
Gustaf Håkansson   +5 more
wiley   +1 more source

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus

open access: yesEpilepsia, EarlyView.
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo   +3 more
wiley   +1 more source

Saccharomyces cerevisiae Mub1, a substrate adaptor of E3 ubiquitin ligase Ubr2, modulates sensitivity to cell wall stressors through multiple transcription factors

open access: yesThe FEBS Journal, EarlyView.
We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika   +7 more
wiley   +1 more source

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