Results 41 to 50 of about 348,872 (362)

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

Stress-Induced Hyperglycemia in General Surgery: a Narrative-Review

Novelty in Biomedicine
Background: Stress-induced hyperglycemia, also known as stress hyperglycemia, occurs after severe stress on the body, such as surgery. Awareness of this condition and its management are essential to reducing complications and mortality in patients after ...
Sina Homaee, Farnaz Saberian, Mohammad Mehdi Atarod, Sahar Kavan   +3 more
doaj   +1 more source

Autophagy in muscle of glucose-infusion hyperglycemia rats and streptozotocin-induced hyperglycemia rats via selective activation of m-TOR or FoxO3.

PLoS ONE, 2014
Autophagy is a conserved process in eukaryotes required for metabolism and is involved in diverse diseases. To investigate autophagy in skeletal muscle under hyperglycemia status, we established two hyperglycemia-rat models that differ in their ...
Pengfei Lv, Jian Huang, Jian Yang, Yujie Deng, Jun Xu, Xiaoyan Zhang, Wenyi Li, Hongli Zhang, Ying Yang   +8 more
doaj   +1 more source

Longitudinal evaluation of cognitive functioning in young children with type 1 diabetes over 18 months [PDF]

, 2016
OBJECTIVE: Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T1D. METHODS: 144
Ambrosino, Jodie, Aye, Tandy, Beck, Roy W, Cato, M. Allison, Cheng, Peiyao, Hershey, Tamara, Kollman, Craig, Mauras, Nelly, Mazaika, Paul, Reiss, Allan L, Ruedy, Katrina J, Tansey, Michael, White, Neil H   +12 more
core   +2 more sources

Fasting glucose and body mass index as predictors of activity in breast cancer patients treated with everolimus-exemestane: the EverExt study [PDF]

, 2017
Evidence on everolimus in breast cancer has placed hyperglycemia among the most common high grade adverse events. Anthropometrics and biomarkers of glucose metabolism were investigated in a observational study of 102 postmenopausal, HR + HER2- metastatic
Barba, M, Botti, C, Botticelli, A, Buglioni, S, Catenaro, T, D'Onofrio, L, Ferranti, F, Filippo, SD, Gamucci, T, Giordano, A, Giordano, Antonio|, Iezzi, L, Lauro, LD, Marchetti, P, Maugeri-Saccà, M, Mentuccia, L, Moscetti, L, Natoli, C, Pizzuti, L, Sanguineti, G, Santini, D, Scinto, AF, Sergi, D, Sperati, F, Tomao, S, Vici, P   +25 more
core   +3 more sources

Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]

, 2020
Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi, Breton, Edith, Cardenas, Andres, Fortin, Carol-Ann, Gagné-Ouellet, Valérie, Guérin, Renée, Hivert, Marie-France, Perron, Patrice, Thibeault, Kathrine   +8 more
core   +1 more source

Admission hyperglycemia as an independent predictor of long‐term prognosis in acute myocardial infarction patients without diabetes: A retrospective study

Journal of Diabetes Investigation, 2021
Aims/Introduction The predictive value of admission hyperglycemia in the long‐term prognosis of acute myocardial infarction patients is still controversial. We aimed to investigate this value based on the diabetes status. Materials and Methods We carried
Cai‐yan Cui, Ming‐gang Zhou, Lian‐chao Cheng, Tao Ye, Yu‐mei Zhang, Feng Zhu, Si‐yi Li, Xing‐lin Jiang, Qiang Chen, Ling‐yao Qi, Xu Chen, Si‐qi Yang, Lin Cai   +12 more
doaj   +1 more source

Genes predisposing to type 1 diabetes mellitus and pathophysiology: a narrative review [PDF]

arXiv, 2021
The possibility of targeting the causal genes along with the mechanisms of pathogenically complex diseases has led to numerous studies on the genetic etiology of some diseases. In particular, studies have added more genes to the list of type 1 diabetes mellitus (T1DM) suspect genes, necessitating an update for the interest of all stakeholders ...
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer’s disease

Communications Biology, 2021
To investigate the effects of chronic hyperglycemia on hippocampal network activity Wirt et al induced sustained hyperglycemia in rats and tested them in a spatial delayed alternation task while recording from the hippocampus and anterior cingulate ...
Ryan. A. Wirt, Lauren. A. Crew, Andrew. A. Ortiz, Adam. M. McNeela, Emmanuel Flores, Jefferson. W. Kinney, James M. Hyman   +6 more
doaj   +1 more source