Results 41 to 50 of about 367,425 (291)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention

Reviews in Cardiovascular Medicine, 2023
Background: Hyperglycemia has been associated with an adverse prognosis in patients with premature coronary artery disease (CAD). However, whether the intermediate hyperglycemia status affects the risk of mortality in premature CAD patients treated with ...
Ziyou Zhou, Linfang Qiao, Yihang Ling, Yibo He, Tian Chang, Hongyu Lu, Sijia Yu, Jin Liu, Wei Guo, Shiqun Chen, Yong Liu, Jiyan Chen   +11 more
doaj   +1 more source

Control of hyperglycaemia in paediatric intensive care (CHiP): study protocol. [PDF]

, 2010
BACKGROUND: There is increasing evidence that tight blood glucose (BG) control improves outcomes in critically ill adults. Children show similar hyperglycaemic responses to surgery or critical illness.
A Ceriello, A Ceriello, A Ceriello, A Chiaretti, A Rovlias, A Russo, A Russo, AA Ferrando, AA Ferrando, Allan Goldman, Ann Truesdale, AP Furnary, AP Furnary, B Halverson-Steele, CK Rayner, Claire Snowdon, D Ardigo, D Ardigo, D Ardigo, D Field, DA Schoenfeld, DC Angus, DC Angus, Deborah Percy, Diana Elbourne, Duncan Macrae, Elizabeth Allen, EV Faustino, G Paret, G Van den Berghe, G Van den Berghe, Helen Betts, J Lacroix, JL Haybittle, JM Hoxworth, John Pappachan, K Esposito, K Katsura, K Malmberg, K Malmberg, Kevin Morris, KJ Jenkins, LM McManus, M Cornblath, MAQ Curley, Margrid Schindler, Mark Peters, MF Oliver, Michael Broadhead, MM Gearhart, NJ Hall, P Lange, PA Li, Paul Baines, Peter-Marc Fortune, R Peto, RE Anderson, RG Branco, Richard Grieve, Robert Tasker, Roger Parslow, S Leteurtre, S Yendamuri, SE Capes, SE Capes, Simon Nadel, Tara Quick, The Acute Respiratory Distress Syndrome Network, TM Vriesendorp, TN Pham, UN Das, UN Das, UN Das, V Srinivasan, WA Pulsinelli, WD Dietrich, Zdenek Slavik   +76 more
core   +5 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Autophagy in muscle of glucose-infusion hyperglycemia rats and streptozotocin-induced hyperglycemia rats via selective activation of m-TOR or FoxO3.

PLoS ONE, 2014
Autophagy is a conserved process in eukaryotes required for metabolism and is involved in diverse diseases. To investigate autophagy in skeletal muscle under hyperglycemia status, we established two hyperglycemia-rat models that differ in their ...
Pengfei Lv, Jian Huang, Jian Yang, Yujie Deng, Jun Xu, Xiaoyan Zhang, Wenyi Li, Hongli Zhang, Ying Yang   +8 more
doaj   +1 more source

Incidence and risk factors of intraoperative hyperglycemia in non-diabetic patients: a prospective observational study

BMC Anesthesiology, 2022
Background Intraoperative hyperglycemia has been associated with multiple postoperative complications such as surgical site infection, myocardial infarction, stroke, and death. These complications are not confined to only diabetic patients.
Varunya Sermkasemsin, Mali Rungreungvanich, Worapot Apinyachon, Inthuon Sangasilpa, Wanlee Srichot, Chawika Pisitsak   +5 more
doaj   +1 more source

Glycocalyx Degradation in Retinal and Choroidal Capillary Endothelium in Rats with Diabetes and Hypertension [PDF]

, 2010
Endothelial glycocalyx (GCX) has been reported as a protective factor for vascular endothelial cells (VEC) in diabetes and hypertension. However, the involvement of GCX impairment in ocular vasculopathy remains unclear.
Kumase, Fumiaki, Mohri, Satoshi, Morizane, Yuki, Ohtsuka, Aiji, Ohtsuki, Hiroshi, Takasu, Ippei   +5 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Hyperglycaemia does not increase perfusion deficits after focal cerebral ischaemia in male Wistar rats [PDF]

, 2018
Background: Hyperglycaemia is associated with a worse outcome in acute ischaemic stroke patients; yet the pathophysiological mechanisms of hyperglycaemia-induced damage are poorly understood.
Dewar, Deborah, Holmes, William M., MacDonald, Kathleen, Macrae, I. Mhairi, Muir, Keith W., Thow, Lisa A.   +5 more
core   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source