Results 51 to 60 of about 255,764 (296)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Incidence and risk factors of intraoperative hyperglycemia in non-diabetic patients: a prospective observational study

BMC Anesthesiology, 2022
Background Intraoperative hyperglycemia has been associated with multiple postoperative complications such as surgical site infection, myocardial infarction, stroke, and death. These complications are not confined to only diabetic patients.
Varunya Sermkasemsin, Mali Rungreungvanich, Worapot Apinyachon, Inthuon Sangasilpa, Wanlee Srichot, Chawika Pisitsak   +5 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Postoperative hyperglycemia in patients with traumatic brain injury: development of a prediction model [PDF]

Introduction Blood glucose monitoring and management are very important for the prognosis of patients with traumatic brain injury (TBI). It is necessary to evaluate the status and influencing factors of hyperglycemia within 48 h after the operation in ...
Xiaowen Zhu, Liuyan Shen, Yi Xia, Xianlan Meng, Xiangyi Yin, Lichun Lu   +5 more
core   +1 more source

Development and Evaluation of a Nurse Anesthestist-Directed Perioperative Hyperglycemia Protocol for Patients Undergoing Elective Major Abdominal Surgery in an Academic Medical Center [PDF]

, 2019
The incidence of diabetes in 2015 was reported as 1.4 million new cases of diabetes among adults ages 18 to 79 (Centers for Disease Control and Prevention [CDC], 2018). Additionally, it is reported that 30.3 million people nationally have diabetes, this
Hein, Dana Marie.
core   +2 more sources

Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention

Reviews in Cardiovascular Medicine, 2023
Background: Hyperglycemia has been associated with an adverse prognosis in patients with premature coronary artery disease (CAD). However, whether the intermediate hyperglycemia status affects the risk of mortality in premature CAD patients treated with ...
Ziyou Zhou, Linfang Qiao, Yihang Ling, Yibo He, Tian Chang, Hongyu Lu, Sijia Yu, Jin Liu, Wei Guo, Shiqun Chen, Yong Liu, Jiyan Chen   +11 more
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Hyperglycemia and acute kidney injury in critically ill children [PDF]

, 2016
Roberto Gordillo,1 Tania Ahluwalia,2 Robert Woroniecki3 1Department of Pediatrics, Division of Nephrology, 2Department of Pediatrics, University of Illinois College of Medicine, Peoria, IL, USA; 3Division of Pediatric Nephrology and Hypertension, Stony ...
Ahluwalia T, Gordillo R, Woroniecki R
core  

Autophagy in muscle of glucose-infusion hyperglycemia rats and streptozotocin-induced hyperglycemia rats via selective activation of m-TOR or FoxO3.

PLoS ONE, 2014
Autophagy is a conserved process in eukaryotes required for metabolism and is involved in diverse diseases. To investigate autophagy in skeletal muscle under hyperglycemia status, we established two hyperglycemia-rat models that differ in their ...
Pengfei Lv, Jian Huang, Jian Yang, Yujie Deng, Jun Xu, Xiaoyan Zhang, Wenyi Li, Hongli Zhang, Ying Yang   +8 more
doaj   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, EarlyView.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source