Postprandial hyperglycemia as an etiological factor in vascular failure
Cardiovascular Diabetology, 2009 Postprandial hyperglycemia is characterized by hyperglycemic spikes that induce endothelial dysfunction, inflammatory reactions and oxidative stress, which may lead to progression of atherosclerosis and occurrence of cardiovascular events.
Inoue Teruo, Node Koichi
doaj +1 more source
Comparison of glycemic excursion in patients with new onset type 2 diabetes mellitus before and after treatment with repaglinide [PDF]
, 2013 Due to industrialization and sedentary life, incidence of type 2 diabetes (DM2) is increasing seriously. Repaglinide is a glucose reducing agent that predominantly reduces post-prandial glucose.
Bonakdaran, S. +4 more
core +1 more source
Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis
Advanced Science, EarlyView.This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang +10 more
wiley +1 more source
Development of a requirement for exogenous insulin treatment in dogs with hyperglycemia
Journal of Veterinary Internal MedicineBackground It has been suggested that overt diabetes mellitus in dogs be defined based on a persistent fasting blood glucose concentration (BGC) >144 mg/dL.
Angielee DiNinni, Rebecka S. Hess
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Childhood Type II Diabetes: The Risks and Complications [PDF]
, 2015 Type II Diabetes Mellitus is an endocrine disorder that affects people of all ages. Type II Diabetes was once considered adult-onset diabetes, as it was nearly exclusively diagnosed in adults. Over the last three decades, the number of children diagnosed
Kapke, Danielle R
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Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]
, 2017 Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan +6 more
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An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
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Advanced Science, EarlyView.A closed‐loop bioelectronic artificial pancreas patch is presented for glucose monitoring and regulation. Utilizing transiently dissolvable microneedle arrays integrated with microtube arrays, the patch efficiently delivers insulin into interstitial fluid, eliminating the need for external long needles. In diabetic pigs, it demonstrates excellent blood
Yiqun Liu +9 more
wiley +1 more source
Hyperglycemia screening based on survey data: an international instrument based on WHO STEPs dataset
BMC Endocrine Disorders, 2022 Background Hyperglycemia is rising globally and its associated complications impose heavy health and economic burden on the countries. Developing effective survey-based screening tools for hyperglycemia using reliable surveillance data, such as the WHO ...
Pooyan Moradifar +2 more
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Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]
, 2017 The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel +21 more
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