Results 11 to 20 of about 13,048 (184)

The Treatment of Hyperhomocysteinemia [PDF]

Annual Review of Medicine, 2009
The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects and by a tendency to promote oxidant stress–induced cellular toxicity. Numerous epidemiological reports have established hyperhomocysteinemia as an independent risk factor for cardiovascular disease, cerebrovascular ...
Bradley A, Maron, Joseph, Loscalzo
openaire   +2 more sources

Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. [PDF]

PLoS ONE, 2017
There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy protects from ischemic stroke.
Sanjana Dayal, Gary L Baumbach, Erland Arning, Teodoro Bottiglieri, Frank M Faraci, Steven R Lentz   +5 more
doaj   +1 more source

Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia

Clinical and Experimental Hypertension, 2020
An increased platelet distribution width (PDW) value has been found in various cardiovascular diseases. The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort.
Gang Li, Yanyan Zhang, Zhongwei Zhu, Juan Du   +3 more
doaj   +1 more source

Anemia, hematinic deficiencies, and hyperhomocysteinemia in serum gastric parietal cell antibody-positive burning mouth syndrome patients without serum thyroid autoantibodies

Journal of Dental Sciences, 2021
Background/purpose: Our previous study found that 70 of 884 burning mouth syndrome (BMS) patients have serum gastric parietal cell antibody (GPCA) positivity but without thyroglobulin antibody (TGA) and thyroid microsomal antibody (TMA) (so-called GPCA ...
Ying-Tai Jin, Yu-Hsueh Wu, Yang-Che Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Andy Sun   +5 more
doaj   +1 more source

Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on 5,10-methylenetetrahydrofolate reductase and multi-vitamin deficiency

Frontiers in Neurology, 2023
Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal
Jiro Fukae, Hiroto Eguchi, Yoichi Wada, Atsuhito Fuse, Rika Chishima, Mitsuyoshi Nakatani, Asuka Nakajima, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo, Yasushi Shimo   +10 more
doaj   +1 more source

Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia

Redox Biology, 2018
Hyperhomocysteinemia due to cystathionine beta synthase (CBS) deficiency is associated with diverse cognitive dysfunction. Considering the role of the serine/threonine kinase DYRK1A, not only in developmental defects with life-long structural and ...
Vanessa Baloula, Marta Fructuoso, Nadim Kassis, Dalale Gueddouri, Jean-Louis Paul, Nathalie Janel   +5 more
doaj   +1 more source

The involvement of hyperhomocysteinemia in the development of characterized depressive disorder in children and adolescents

European Psychiatry, 2023
Introduction Elevated blood levels of homocysteine have been associated with several psychiatric and neurodegenerative disorders such as schizophrenic disorders, Alzheimer’s disease, Parkinson’s disease and depression. The hypothesis is that genetic and
Z. Elmaataoui, H. BELHADGA, H. KISRA
doaj   +1 more source

Role of hyperhomocysteinemia and Vitamin B12 deficiency in central and hemi-central retinal vein occlusion: A case–control study

Oman Journal of Ophthalmology, 2022
BACKGROUND: Retinal venous occlusive diseases have been recognized as a major cause of ocular morbidity. Hyperhomocysteinemia could be a potentially modifiable risk factor.
Dhipak Arthur, Deepa John, Jude Joseph Fleming, Grace Rebekah, Mahasampath Gowri, Sheeja Susan John   +5 more
doaj   +1 more source

Familial hyperhomocysteinemia, age and peripheral vascular diseases - an Italian study

Veins and Lymphatics, 2013
Hyperhomocysteinemia is a widely recognized, although not yet entirely understood, risk factor for cardiovascular disease. Particularly, the complex relationships between age, hyperhomocysteinemia, predisposing genetic factors and peripheral vascular ...
Sandro Michelini, Marco Cardone, Adriano Micci, Francesco Cappellino, Alessandro Fiorentino, Vincenzo Sainato, Maira Moira, Rachele Todisco, Maddalena Todini, Serena Michelini, Guido Valle   +10 more
doaj   +1 more source

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia

SAGE Open Medicine, 2020
Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres, Lisneth Osiris Matias-Aguilar, Erika Coria-Ramirez, Edmundo Bonilla-Gonzalez, Humberto Gonzalez-Marquez, Isabel Ibarra-Gonzalez, Jose Rubicel Hernandez-Lopez, Jesus Hernandez-Juarez, Victor Manuel Dominguez-Reyes, Irma Isordia-Salas, Abraham Majluf-Cruz   +10 more
doaj   +1 more source