Results 11 to 20 of about 13,370 (136)

Analysis of the Mediating Role of Cytokines in the Relationship Between Nonalcoholic Fatty Liver Disease and Cognitive Impairment After Ischemic Stroke. [PDF]

Brain Behav
This article reveals the mediating role of cytokine levels between non‐alcoholic fatty liver disease and post‐stroke cognitive impairment, providing new therapeutic targets for post‐stroke cognitive dysfunction. Abstract Objective To explore whether nonalcoholic fatty liver disease (NAFLD) is associated with poststroke cognitive impairment (PSCI) and ...
Du X, Li J.
europepmc   +2 more sources

Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on 5,10-methylenetetrahydrofolate reductase and multi-vitamin deficiency

Frontiers in Neurology, 2023
Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal
Jiro Fukae, Hiroto Eguchi, Yoichi Wada, Atsuhito Fuse, Rika Chishima, Mitsuyoshi Nakatani, Asuka Nakajima, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo, Yasushi Shimo   +10 more
doaj   +1 more source

Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia

Redox Biology, 2018
Hyperhomocysteinemia due to cystathionine beta synthase (CBS) deficiency is associated with diverse cognitive dysfunction. Considering the role of the serine/threonine kinase DYRK1A, not only in developmental defects with life-long structural and ...
Vanessa Baloula, Marta Fructuoso, Nadim Kassis, Dalale Gueddouri, Jean-Louis Paul, Nathalie Janel   +5 more
doaj   +1 more source

The involvement of hyperhomocysteinemia in the development of characterized depressive disorder in children and adolescents

European Psychiatry, 2023
Introduction Elevated blood levels of homocysteine have been associated with several psychiatric and neurodegenerative disorders such as schizophrenic disorders, Alzheimer’s disease, Parkinson’s disease and depression. The hypothesis is that genetic and
Z. Elmaataoui, H. BELHADGA, H. KISRA
doaj   +1 more source

Role of hyperhomocysteinemia and Vitamin B12 deficiency in central and hemi-central retinal vein occlusion: A case–control study

Oman Journal of Ophthalmology, 2022
BACKGROUND: Retinal venous occlusive diseases have been recognized as a major cause of ocular morbidity. Hyperhomocysteinemia could be a potentially modifiable risk factor.
Dhipak Arthur, Deepa John, Jude Joseph Fleming, Grace Rebekah, Mahasampath Gowri, Sheeja Susan John   +5 more
doaj   +1 more source

Familial hyperhomocysteinemia, age and peripheral vascular diseases - an Italian study

Veins and Lymphatics, 2013
Hyperhomocysteinemia is a widely recognized, although not yet entirely understood, risk factor for cardiovascular disease. Particularly, the complex relationships between age, hyperhomocysteinemia, predisposing genetic factors and peripheral vascular ...
Sandro Michelini, Marco Cardone, Adriano Micci, Francesco Cappellino, Alessandro Fiorentino, Vincenzo Sainato, Maira Moira, Rachele Todisco, Maddalena Todini, Serena Michelini, Guido Valle   +10 more
doaj   +1 more source

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia

SAGE Open Medicine, 2020
Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres, Lisneth Osiris Matias-Aguilar, Erika Coria-Ramirez, Edmundo Bonilla-Gonzalez, Humberto Gonzalez-Marquez, Isabel Ibarra-Gonzalez, Jose Rubicel Hernandez-Lopez, Jesus Hernandez-Juarez, Victor Manuel Dominguez-Reyes, Irma Isordia-Salas, Abraham Majluf-Cruz   +10 more
doaj   +1 more source

Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with normocytosis

Journal of the Formosan Medical Association, 2020
Background/Purpose: Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether 944 atrophic glossitis (AG) patients with normocytosis had significantly higher frequencies of anemia ...
Chun-Pin Chiang, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Andy Sun   +5 more
doaj   +1 more source

Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in oral lichen planus patients with or without hyperhomocysteinemia

Journal of Dental Sciences
Background/purpose: Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly ...
Yi-Pang Lee, Ying-Tai Jin, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang   +5 more
doaj   +1 more source

Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors

Neurobiology of Disease, 2019
Hyperhomocysteinemia has been implicated in several neurodegenerative disorders including ischemic stroke. However, the pathological consequences of ischemic insult in individuals predisposed to hyperhomocysteinemia and the associated etiology are ...
Ankur Jindal, Sathyanarayanan Rajagopal, Lucas Winter, Joshua W. Miller, Donald W. Jacobsen, Jonathan Brigman, Andrea M. Allan, Surojit Paul, Ranjana Poddar   +8 more
doaj   +1 more source