Results 21 to 30 of about 12,970 (183)

Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia

Redox Biology, 2018
Hyperhomocysteinemia due to cystathionine beta synthase (CBS) deficiency is associated with diverse cognitive dysfunction. Considering the role of the serine/threonine kinase DYRK1A, not only in developmental defects with life-long structural and ...
Vanessa Baloula, Marta Fructuoso, Nadim Kassis, Dalale Gueddouri, Jean-Louis Paul, Nathalie Janel   +5 more
doaj   +1 more source

Role of hyperhomocysteinemia and Vitamin B12 deficiency in central and hemi-central retinal vein occlusion: A case–control study

Oman Journal of Ophthalmology, 2022
BACKGROUND: Retinal venous occlusive diseases have been recognized as a major cause of ocular morbidity. Hyperhomocysteinemia could be a potentially modifiable risk factor.
Dhipak Arthur, Deepa John, Jude Joseph Fleming, Grace Rebekah, Mahasampath Gowri, Sheeja Susan John   +5 more
doaj   +1 more source

Familial hyperhomocysteinemia, age and peripheral vascular diseases - an Italian study

Veins and Lymphatics, 2013
Hyperhomocysteinemia is a widely recognized, although not yet entirely understood, risk factor for cardiovascular disease. Particularly, the complex relationships between age, hyperhomocysteinemia, predisposing genetic factors and peripheral vascular ...
Sandro Michelini, Marco Cardone, Adriano Micci, Francesco Cappellino, Alessandro Fiorentino, Vincenzo Sainato, Maira Moira, Rachele Todisco, Maddalena Todini, Serena Michelini, Guido Valle   +10 more
doaj   +1 more source

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia

SAGE Open Medicine, 2020
Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres, Lisneth Osiris Matias-Aguilar, Erika Coria-Ramirez, Edmundo Bonilla-Gonzalez, Humberto Gonzalez-Marquez, Isabel Ibarra-Gonzalez, Jose Rubicel Hernandez-Lopez, Jesus Hernandez-Juarez, Victor Manuel Dominguez-Reyes, Irma Isordia-Salas, Abraham Majluf-Cruz   +10 more
doaj   +1 more source

Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with normocytosis

Journal of the Formosan Medical Association, 2020
Background/Purpose: Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether 944 atrophic glossitis (AG) patients with normocytosis had significantly higher frequencies of anemia ...
Chun-Pin Chiang, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Andy Sun   +5 more
doaj   +1 more source

Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in oral lichen planus patients with or without hyperhomocysteinemia

Journal of Dental Sciences
Background/purpose: Our previous study found that 124 of 588 oral lichen planus (OLP) patients have hyperhomocysteinemia. This study assessed whether these 124 OLP patients with hyperhomocysteinemia (hyperhomocysteinemia/OLP patients) had significantly ...
Yi-Pang Lee, Ying-Tai Jin, Julia Yu-Fong Chang, Yi-Ping Wang, Andy Sun, Chun-Pin Chiang   +5 more
doaj   +1 more source

Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors

Neurobiology of Disease, 2019
Hyperhomocysteinemia has been implicated in several neurodegenerative disorders including ischemic stroke. However, the pathological consequences of ischemic insult in individuals predisposed to hyperhomocysteinemia and the associated etiology are ...
Ankur Jindal, Sathyanarayanan Rajagopal, Lucas Winter, Joshua W. Miller, Donald W. Jacobsen, Jonathan Brigman, Andrea M. Allan, Surojit Paul, Ranjana Poddar   +8 more
doaj   +1 more source

Serum B12, homocysteine levels, and their effect on peripheral neuropathy in Parkinson's disease: Indian cohort

Annals of Indian Academy of Neurology, 2020
Background: Cobalamin deficiency, either due to dietary inadequacy or increased consumption attributable to levodopa-mediated metabolic disturbance, and resultant hyperhomocysteinemia may contribute to peripheral neuropathy (PN) in Parkinson's disease ...
Neeharika L Mathukumalli, Mridula R Kandadai, Jabeen A Shaik, Meena A Kanikannan, Rupam Borgohain   +4 more
doaj   +1 more source

Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development

Physiological Reports, 2022
Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of early pregnancy loss and placenta‐related complications of pregnancy, including pre ...
Nadejda Capatina, Graham J. Burton, Hong Wa Yung   +2 more
doaj   +1 more source

Hyperhomocysteinemia [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
[No abstract available]
Karter, Y, Uzun, H, Çurgunlu, A, Aydyn, S, Ertürk, N, Vehid, S, Pimpek, G   +6 more
openaire   +4 more sources