Results 31 to 40 of about 38,804 (257)

The prevalence and clinical relevance of hyperhomocysteinemia suggesting vitamin B12 deficiency in presumed healthy infants.

European journal of paediatric neurology, 2021
BACKGROUND Previous studies have demonstrated a high prevalence of biochemical vitamin B12 deficiency in infants in Norway. Increased total homocysteine (tHcy) is the most important marker of B12 deficiency in infants.
U. Ljungblad, Henriette Paulsen, L. Mørkrid, R. Pettersen, H. Hager, M. Lindberg, Henriette Astrup, E. Eklund, A. Bjørke-Monsen, T. Rootwelt, Trine Tangeraas   +10 more
semanticscholar   +1 more source

Accelerated epigenetic aging as a modifier of homocysteine-associated cognitive decline: Findings from NHANES. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Hyperhomocysteinemia represents a modifiable risk factor for cognitive decline and dementia, yet the role of epigenetic aging mechanisms in mediating this association remain poorly characterized, limiting development of targeted interventions.
Li H, Chen Y, Wang Z, Wang Y, Bi R, Hou J, Chen H, Zhang Z, Guo Z, Chen Z, Cui H, Li S.   +11 more
europepmc   +2 more sources

Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia. [PDF]

PLoS ONE, 2014
Diet-induced hyperhomocysteinemia produces endothelial and cardiac dysfunction and promotes thrombosis through a mechanism proposed to involve oxidative stress.
Sanjana Dayal, Ilya O Blokhin, Rochelle A Erger, Melissa Jensen, Erland Arning, Jeff W Stevens, Teodoro Bottiglieri, Frank M Faraci, Steven R Lentz   +8 more
doaj   +1 more source

Endothelial Dysfunction and Hyperhomocysteinemia-Linked Cerebral Small Vessel Disease: Underlying Mechanisms and Treatment Timing

Frontiers in Neurology, 2021
Cerebral small vessel disease (cSVD)—a common cause of stroke and vascular dementia—is a group of clinical syndromes that affects the brain's small vessels, including arterioles, capillaries, and venules.
Shuang Li, Guang-qin Li, Xia Luo, Yan-Ran Huang, Lan Wen, Jinglun Li   +5 more
semanticscholar   +1 more source

Central and Systemic Responses to Methionine-Induced Hyperhomocysteinemia in Mice [PDF]

, 2014
Hyperhomocysteinemia has been considered a risk factor for neuropsychiatric disorders, but the mechanisms involved in this process have not been completely elucidated.
D'Almeida, Vania, Rezende, Marina Mastelaro de   +1 more
core   +12 more sources

Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. [PDF]

PLoS ONE, 2017
There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy protects from ischemic stroke.
Sanjana Dayal, Gary L Baumbach, Erland Arning, Teodoro Bottiglieri, Frank M Faraci, Steven R Lentz   +5 more
doaj   +1 more source

Case report: Young-onset large vessel ischemic stroke due to hyperhomocysteinemia associated with the C677T polymorphism on 5,10-methylenetetrahydrofolate reductase and multi-vitamin deficiency

Frontiers in Neurology, 2023
Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal
Jiro Fukae, Hiroto Eguchi, Yoichi Wada, Atsuhito Fuse, Rika Chishima, Mitsuyoshi Nakatani, Asuka Nakajima, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo, Yasushi Shimo   +10 more
doaj   +1 more source

Evaluation of platelet distribution width in hypertension with hyperhomocysteinemia

Clinical and Experimental Hypertension, 2020
An increased platelet distribution width (PDW) value has been found in various cardiovascular diseases. The objective of this study was to evaluate the association between the PDW and hypertension with hyperhomocysteinemia in an elderly cohort.
Gang Li, Yanyan Zhang, Zhongwei Zhu, Juan Du   +3 more
doaj   +1 more source

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Adachi T, Andersson A, Bagi Z, Bellamy MF, Chambers JC, Chambers JC, Chao CL, Flohé L, Forgione MA, Guttormsen AB, Huang R-FS, Kanani PM, Karlsson K, Lang D, Lentz SR, Mansoor MA, Mansoor MA, Mansoor MA, Mansoor MA, O'Donnell VB, Outinen PA, Pritchard, Rubbo H, Tawakol A, Ungvari Z, Weiss N, Wilcken DE, Woo KS, Zhang F, Zhang X   +29 more
core   +1 more source

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]

, 2016
BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki, Kanematsu, Yasuhisa, Kitazato, Keiko T, Korai, Masaaki, Matsushita, Nobuhisa, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Shimada, Kenji, Tada, Yoshiteru   +9 more
core   +2 more sources