Results 161 to 170 of about 82,926 (310)

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Analysis of Risk Factors for Normal Glucose Tolerance-Hyperinsulinemia [PDF]

, 2018
The aim of this paper is to study the prevalence of individuals with normal glucose tolerance-hyperinsulinemia in Nanshan of Shenzhen, determine the cut point values of normal glucose tolerance-hyperinsulinemia, and investigate the risk factors for it ...
Li, MD, Lian, Nie, MD, Lei, Ye, MD, Xiaoman, Yu, MD, Ming, Ai, MD, Wei, Zhong, MD, Zhibiao, Chi, MD, Lianxiang   +6 more
core  

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Caloric Restriction in Alstrom Syndrome Prevents Hyperinsulinemia

, 2011
Alstrom syndrome (AS; OMIM 203800) is an autosomal recessive disorder characterized by cone-rod dystrophy, dilated cardiomyopathy, sensorineural hearing impairment, developmental delay, and most case had both childhood -onset obesity and hyperinsulinemia.
LEE, NI-CHUNG;CHIEN, YIN-HSIU;TSAI, WEN-YU;HWU, WUH-LIANG, 李妮鍾;簡穎秀;蔡文友;胡務亮   +1 more
core  

Continuous Intraperitoneal Insulin Infusion for People With Type 1 Diabetes: A Literature Review and International Position Statement

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8801-8811, October 2026.
ABSTRACT Achieving glucose targets without hypoglycaemia is the treatment goal in type 1 diabetes. Structured education, intensified insulin injection regimens, continuous glucose monitoring, automated insulin delivery, and ongoing support from a multidisciplinary team all support people with type 1 diabetes to achieve this goal. Despite these advances,
Nick Oliver, Bernhard Gehr, Rayhan Lal, Peter R. van Dijk, Eric Renard   +4 more
wiley   +1 more source

Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9230-9238, October 2026.
ABSTRACT Introduction Diabetic foot ulcers and heart failure are severe complications of diabetes mellitus, both associated with high morbidity and mortality. Whether diabetic foot ulcers worsen prognosis in people with heart failure remains unclear.
A. Rumanes, G. C. M. Linssen, J. J. van Netten, J. E. W. C. van Gemert‐Pijnen, J. G. van Baal   +4 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (MEDFINE‐RWD)

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9461-9472, October 2026.
ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez, Antonio Tejera‐Muñoz, Patricia Tomás‐Gómez, Federico Vázquez‐San Miguel, Virginia Soria‐Utrilla, Ada María Roldán‐Sánchez, Maya Sánchez‐Baya, Jersy Cárdenas‐Salas, Blanca Timón‐Vázquez, Juan J. Gorgojo‐Martínez, Ines Modrego‐Pardo, Irea Fernández‐Xove, Jose Carlos Fernández‐García, Rebeca Reyes‐García   +13 more
wiley   +1 more source

Selective glomerular hypofiltration is associated with glucometabolic disturbances in the general population

Journal of Internal Medicine, Volume 300, Issue 4, Page 499-512, October 2026.
Abstract Background Discordance between cystatin C‐ and creatinine‐based estimated glomerular filtration rate (eGFR) has been linked to adverse outcomes. A low eGFRcys/eGFRcr‐ratio, conceptualized as selective glomerular hypofiltration syndrome (SGHS), has been hypothesized to reflect early metabolic kidney vulnerability, although non‐glomerular ...
Christopher Nilsson, Agne Laucyte‐Cibulskiene, Amra Jujic, Marcus A. Ohlsson, Gregor Guron, Maria K. Svensson, Maria Weiner, P. Andreas Jonsson, Johan Ärnlöv, Gunnar Engström, Anders Grubb, Anders Larsson, Martin Magnusson, Anders Christensson   +13 more
wiley   +1 more source

NONcNZO10/LtJ and TALLY‐HO/JngJ Mice as Novel Models of Diabetic Peripheral Neuropathy

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Animal models of diabetic peripheral neuropathy (DPN) are essential for understanding disease mechanisms and evaluating therapies. We characterized two polygenic mouse strains, RCS10 and TH, and found that both developed obesity, hyperglycemia, dyslipidemia, and DPN.
Stéphanie A. Eid, Andrew D. Carter, Emily J. Koubek, John M. Hayes, Diana M. Rigan, Chloe Kiriluk, Crystal M. Pacut, Phillipe D. O'Brien, Jihyun Park, Dae‐Gyu Jang, Eva L. Feldman   +10 more
wiley   +1 more source

How the First 9 Months Shape the Rest of Your Life: The Impact of Gestational Diabetes on the Metabolic Future. [PDF]

Diabetes Obes Metab
ABSTRACT Gestational diabetes mellitus (GDM) represents far more than a transient glycaemic disorder: it is a sentinel metabolic event that unveils pre‐existing defects in β‐cell function and insulin action, with profound implications for both maternal and offspring cardiometabolic health across the lifespan.
Kanat M, Abdul-Ghani M, DeFronzo RA.
europepmc   +2 more sources