Results 151 to 160 of about 82,926 (310)

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

Chronic hyperinsulinemia and blood pressure regulation

, 1990
The aims of this study were to determine whether chronic hyperinsulinemia, comparable to that found in obese hypertensives, elevates mean arterial pressure (MAP) or potentiates the hypertensive effects of angiotensin II (ANG II).
H. L. Mizelle, M. J. Smith, J. E. Hall, T. G. Coleman   +3 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Targeting Overweight and Obesity Phenotypes for Secondary Prevention of Cardiovascular Disease: A Call to Action for the Middle East and Beyond

Obesity Reviews, EarlyView.
ABSTRACT Although there are conflicting clinical data on the efficacy of weight reduction in reducing secondary events in patients with comorbid overweight and obesity (OAO) and cardiovascular disease (CVD), there is excellent epidemiological and biological evidence of a cause–effect relationship between OAO, CVD, and other systemic complications ...
Wael Almahmeed, Juan S. Barajas‐Gamboa, Mohammad Zubaid, Ebaa Al Ozairi, Abdullah Shehab, Khalid Al‐Rasadi, Charbel Abi Khalil, Noor Al Busaidi, Fahad Al Sindi, Zuhier Awan, Tomader Ali, Khaldoon Al‐Humood, Fatheya Al Awadi, Mohammed Al Hadad, Manal Al Kindi, Khalid Al Habib, Khalid Al Waili, Maryam Alsaeed, Adel Tash, Hani Sabbour   +19 more
wiley   +1 more source

Insulin Resistance and Hyperinsulinemia: the Egg and the Chicken.

Journal of Clinical Endocrinology and Metabolism, 2021
M. Abdul-Ghani, R. DeFronzo
semanticscholar   +1 more source

The Effect of Lipemia on Insulin and Adiponectin Measurement in Equine Blood Samples

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Lipemia is a common comorbidity in horses with obesity or equine metabolic syndrome, but the impact of lipemia on the measurement of insulin and adiponectin has not been evaluated. Objective To evaluate endogenous and exogenous lipemic interference with equine insulin and adiponectin measurements via several commercial assays ...
Kimberly L. Hallowell, Andrew W. van Eps, Jeaneen C. Kulp, Lauren V. Schnabel   +3 more
wiley   +1 more source

Effect of acute hyperinsulinemia on ventricular repolarization in uncomplicated obesity

, 2005
Background: Acute hyperinsulinemia has been shown to increase QTc interval in lean subjects, but data on obese subjects are still unclear. Aim of this study was to evaluate the effect of acute hyperinsulinemia on QTc interval and QTc dispersion in ...
VECCI, Elio Giancarlo, CURIONE, Mario, Di Bona, Simonetta, Umberto Di Mario, Ribaudo, Maria Cristina, Alessandra Zappaterreno, Maria Cristina Ribaudo, LEONETTI, Frida, Iacobellis, Gianluca, Vecci, Elio, Di Mario, Umberto, Zappaterreno, Alessandra, Gianluca Iacobellis, Simonetta Di Bona   +13 more
core   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, Volume 159, Issue 8, Page 1928-1936, 15 October 2026.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

MR Derived Cardiac Metabolism Changes in Patients With Obesity and Diabetes: Knowledge Discovery Via Bayesian Networks and Random Forest Classification

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Characterization of healthy vs. diabetic (73:67$$ 73:67 $$) random forest classification group and its Bayesian network learned through NOTEARS structure algorithm on multi‐modal data. Shown computed SHapley Additive exPlanation (SHAP) values for various features.
Ina Hanninger, Andrej Krafčík, Eylem Levelt, Jennifer J Rayner, Chistopher T Rodgers, Stefan Neubauer, Vicente Grau, Oliver J Rider, Ladislav Valkovič   +8 more
wiley   +1 more source