Results 151 to 160 of about 10,623 (193)
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New England Journal of Medicine, 1933
Hyperinsulinism is the term suggested by Harris 1 in 1924 in explanation of spontaneous hypoglycemia. If there is insufficient insulin, hyperglycemia and diabetes mellitus develop; if insulin is excessive, hypoglycemia develops, with the characteristic symptoms seen after an overdose of insulin.
E. STARR JUDD +2 more
+4 more sources
Hyperinsulinism is the term suggested by Harris 1 in 1924 in explanation of spontaneous hypoglycemia. If there is insufficient insulin, hyperglycemia and diabetes mellitus develop; if insulin is excessive, hypoglycemia develops, with the characteristic symptoms seen after an overdose of insulin.
E. STARR JUDD +2 more
+4 more sources
Hyperinsulinism and hyperammonaemia
Journal of Inherited Metabolic Disease, 1998Hyperinsulinism and hyperammonaemia L . Al-Shamsan1, M. Al-Essa2, A. Al-Mutair2, A. Al-Ashwal2, N. Sakati2 and P. T . Ozand2,3* 1 Department of Pediatrics, King Fahad National Guard Hospital, Riyadh ; 2 Department of Pediatrics, King Faisal Specialist Hospital and Research Centre ; 3 Department of Biological and Medical Research, King Faisal Specialist
L, al-Shamsan +5 more
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Journal of Paediatrics and Child Health, 1989
Abstract Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side‐effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure.
L C, Low +4 more
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Abstract Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side‐effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure.
L C, Low +4 more
openaire +2 more sources
Clinics in Perinatology, 1998
Hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in neonates and young infants. Timely diagnosis and aggressive treatment are necessary to prevent long-term neurologic sequelae. This article explores the latest advances in the understanding of the pathophysiology of this disorder at the molecular and cellular level.
V M, Schwitzgebel, S E, Gitelman
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Hyperinsulinism is the most frequent cause of severe, persistent hypoglycemia in neonates and young infants. Timely diagnosis and aggressive treatment are necessary to prevent long-term neurologic sequelae. This article explores the latest advances in the understanding of the pathophysiology of this disorder at the molecular and cellular level.
V M, Schwitzgebel, S E, Gitelman
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Current Opinion in Pediatrics, 2013
Congenital hyperinsulinism (CHI) is a multifaceted disease and continues to be the most common cause of persistent hypoglycemia in infants. The purpose of the review is to highlight important recent developments regarding CHI.Several recent studies have highlighted the advances in medical genetics, imaging techniques, histological variety, and surgical
openaire +2 more sources
Congenital hyperinsulinism (CHI) is a multifaceted disease and continues to be the most common cause of persistent hypoglycemia in infants. The purpose of the review is to highlight important recent developments regarding CHI.Several recent studies have highlighted the advances in medical genetics, imaging techniques, histological variety, and surgical
openaire +2 more sources
Annals of Pharmacotherapy, 1997
In a limited number of case reports in infants, octreotide raised the blood glucose concentrations and decreased glucose requirements sufficiently to avoid pancreatectomy. This response occurs in the presence of frequent feedings and diazoxide therapy, and lasts from 1 month to greater than 5 years.
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In a limited number of case reports in infants, octreotide raised the blood glucose concentrations and decreased glucose requirements sufficiently to avoid pancreatectomy. This response occurs in the presence of frequent feedings and diazoxide therapy, and lasts from 1 month to greater than 5 years.
openaire +2 more sources
Seminars in Fetal and Neonatal Medicine, 2005
Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic aetiology and response to medical therapy. The clinical heterogeneity may range from severe life-threatening disease to very mild clinical symptoms.
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Congenital hyperinsulinism is a cause of persistent hypoglycaemia in the neonatal period. It is a heterogeneous disease with respect to clinical presentation, molecular biology, genetic aetiology and response to medical therapy. The clinical heterogeneity may range from severe life-threatening disease to very mild clinical symptoms.
openaire +2 more sources
Fetal hyperinsulinism in anencephaly
American Journal of Obstetrics and Gynecology, 1989Insulin was measured in the blood collected in utero from three midtrimester anencephalic fetuses. The hyperinsulinism found could be due to an underutilization of glucose in the absence of most of the brain and could be responsible for the relatively normal growth in anencephaly despite the absence of the hypothalamohypophysial axis.
Hubinont, C +3 more
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Hyperinsulinism of the newborn
Seminars in Perinatology, 2000Neonatal hyperinsulinism (HI) is a clinical syndrome of pancreatic beta-cell dysfunction characterized by failure to suppress insulin secretion in the presence of hypoglycemia. Although rare, it is the most common cause for persistent hypoglycemia in the newborn period.
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New England Journal of Medicine, 1971
IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts.
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IN attempting to evolve a unitary concept to explain the metabolic and clinical aberrations of diabetes mellitus, one is hard put to find a single defect that will satisfy all the known facts.
openaire +2 more sources