Results 201 to 210 of about 14,238 (246)
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Congenital Hyperinsulinism: An Historical Perspective
Hormone Research in Paediatrics, 2022Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since the first case descriptions in the 1950s, the field has advanced significantly.
P. Thornton +2 more
semanticscholar +1 more source
Congenital hyperinsulinism: recent updates on molecular mechanisms, diagnosis and management
Journal of Pediatric Endocrinology & Metabolism (JPEM), 2021Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe hypoglycaemia in the neonatal period and early childhood. Mutations in 16
D. Giri, Katherine Hawton, S. Senniappan
semanticscholar +1 more source
THE ENCEPHALOPATHY OF HYPERINSULINISM
Annals of Internal Medicine, 19491. A case of severe hyperinsulinism in a juvenile diabetic is reported in which unconsciousness was produced for over 72 hours. 2. Emphasis is placed on the unreliability of the urine as an initial diagnostic indicator in coma seen during the course of extremely labile diabetes mellitus. 3. Globin insulin, in large doses, is shown to have a cumulative,
S. K. Fineberg, Alexander Altschul
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Hyperinsulinism in the Neonate
Clinics in Perinatology, 2018Hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants. Prompt recognition and treatment, independent of whether infants have transient or permanent HI, are essential to decrease risk of neurologic damage. The most common form of congenital HI is due to inactivating mutations of the β-cell ATP-sensitive potassium (KATP) channel
Katherine Lord +2 more
openaire +3 more sources
Journal of Paediatrics and Child Health, 1989
Abstract Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side‐effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure.
E. C. L. Yu +4 more
openaire +3 more sources
Abstract Five infants with persistent hypoglycaemia due to hyperinsulinism were reported. Provocative tests for insulin release were unhelpful. Diazoxide was useful in the treatment of three patients but many side‐effects were observed. These included petechial rash, hypertrichosis, acute renal failure, fluid retention and cardiac failure.
E. C. L. Yu +4 more
openaire +3 more sources