Results 21 to 30 of about 1,613 (188)

Association between hyperketonemia in early lactation and culling and hyperketonemia in subsequent lactation in Holstein dairy cows

American Association of Bovine Practitioners Conference Proceedings, 2019
Hyperketonemia (HYK) is an early lactation metabolic disease frequently observed in high-producing dairy cattle and it has been associated with suboptimal reproductive performance, decreased milk yield, increase occurrence of other diseases, and increase in culling. The majority of the reports so far focused on the association of HYK and these outcomes
Rodriguez, Z. R., Lukach, J., Wynands, E., Ferro, P. P. C., Cramer, G., Caixeta, L. S.   +5 more
openaire   +2 more sources

Longitudinal Phenotypes Improve Genotype Association for Hyperketonemia in Dairy Cattle [PDF]

Animals, 2019
The objective of our study was to identify genomic regions associated with varying concentrations of non-esterified fatty acid (NEFA), β-hydroxybutyrate (BHB), and the development of hyperketonemia (HYK) in longitudinally sampled Holstein dairy cows. Our study population consisted of 147 multiparous cows intensively characterized by serial NEFA and BHB
Francisco A. Leal Yepes, Daryl V. Nydam, Sabine Mann, Luciano Caixeta, Jessica A. A. McArt, Thomas R. Overton, Joseph J Wakshlag, Heather J. Huson   +7 more
openaire   +3 more sources

Role of Hyperketonemia in Inducing Oxidative Stress and Cellular Damage in Cultured Hepatocytes and Type 1 Diabetic Rat Liver [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: Type 1 diabetic (T1D) patients have a higher incidence of liver disease. T1D patients frequently experience elevated plasma ketone levels along with hyperglycemia. However, no study has examined whether hyperketonemia per se has any role
Preeti Kanikarla-Marie, Sushil K. Jain
doaj   +2 more sources

The Hyperglycemia and Hyperketonemia Impaired Bone Microstructures: A Pilot Study in Rats [PDF]

Frontiers in Endocrinology, 2020
Though diabetes mellitus (DM) is one of the known causes of osteoporosis, it is also realized that ketogenic diet (KD), an effective regimen for epilepsy, impairs bone microstructures.
Qi Liu, Zhou Yang, Chuhai Xie, Long Ling, Hailan Hu, Yanming Cao, Yan Huang, Qingan Zhu, Yue Hua   +8 more
doaj   +3 more sources

Investigating the epidemiology of hyperketonemia in grazing dairy cows in early lactation: Incidence, prevalence, and time to resolution of hyperketonemia

Journal of Dairy Science
: Most cows experience a degree of negative energy balance due to an energy deficit during early lactation, which leads to the mobilization of body tissue to support milk production and results in the production of ketone bodies.
S.J. Hendriks, J.R. Roche, J.A.A. McArt, T.M. Grala, S-A. Turner, C.R. Burke, B. Kuhn-Sherlock, C.V.C. Phyn   +7 more
doaj   +3 more sources

Amelioration of postpartum hyperketonemia using amino acids, cyanocobalamin, inositol, α-lipoic acid, or monensin during the transition period of dairy cows

Journal of Dairy Science
: Strategies for the prevention of hyperketonemia, or subclinical ketosis, based on providing additional glucose or glucose precursors provide discordant results suggesting that other poorly understood metabolic factors may potentially contribute to the ...
A. Lisuzzo, A. Valenza, A. Bach, A. Biancucci, B. Contiero, F. Cecchini, E. Fiore   +6 more
doaj   +2 more sources

Financial impact of hyperketonemia [PDF]

, 2014
Almost 70% of the cost of losses from hyperketonemia, including future reproductive losses, future milk losses and future culling losses, are ...
McArt, Jessica, Nydam, Daryl
core   +6 more sources

Fetal glucose utilization in response to maternal starvation and acute hyperketonemia

American Journal of Physiology-Endocrinology and Metabolism, 1989
The effects of maternal hypoglycemia and/or hyperketonemia on glucose utilization by individual fetal rat tissues have been studied in vivo. To decrease blood glucose and to raise fetal blood ketone body concentrations, 19-day pregnant rats were submitted to 48 or 96 h of starvation.
A, Leturque, S, Hauguel, J P, Revelli, A F, Burnol, J, Kandé, J, Girard   +5 more
openaire   +3 more sources

Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia

American Journal of Physiology-Endocrinology and Metabolism, 1996
During starvation, brain energy metabolism in humans changes toward oxidation of ketone bodies. To investigate if this shift is directly coupled to circulating blood concentrations of ketone bodies, we measured global cerebral blood flow (CBF) and global cerebral carbohydrate metabolism with the Kety-Schmidt technique before and during intravenous ...
Hasselbalch, S G, Madsen, P L, Hageman, L P, Olsen, K S, Justesen, N, Holm, S, Paulson, O B   +6 more
openaire   +4 more sources

Revisiting the thrifty substrate hypothesis: Ketone bodies as cardioprotective fuels in diabetes and SGLT2 inhibitor therapy. [PDF]

J Diabetes Investig
SGLT2 inhibitors increase circulating β‐hydroxybutyrate (β‐OH‐B), a ketone body that may enhance cardiac efficiency in HFrEF. The “thrifty substrate hypothesis” suggests β‐OH‐B provides more ATP per oxygen consumed than glucose or fatty acids. Clinical studies by Nielsen et al. and Solis‐Herrera et al. show that β‐OH‐B infusion improves cardiac output,
Suzuki Y, Amano T.
europepmc   +2 more sources