Results 201 to 210 of about 7,125 (253)

Hyperleukocytosis: Emergency Management

The Indian Journal of Pediatrics, 2012
Hyperleukocytosis is defined as peripheral blood leukocyte count exceeding 100,000/mm(3). Acute leukemia is the most common etiology in pediatric practice. Hyperleukocytosis is a medical emergency. The increased blood viscosity, secondary to high white cell count and leukocyte aggregates, results in stasis in the smaller blood vessels. This predisposes
Richa, Jain, Deepak, Bansal, R K, Marwaha   +2 more
openaire   +2 more sources

Pegfilgrastim-Induced Hyperleukocytosis

Annals of Pharmacotherapy, 2007
Objective: To report a pediatric case of pegfilgrastim-induced hyperleukocytosis. Case Summary: A 3-year-old boy with medulloblastoma therapy presented with white blood cell (WBC) count 0.1 × 103/μL and absolute neutrophil count (ANC) 0.014 × 103/μL on day 27 following a course of induction chemotherapy. The patient received pegfilgrastim 200 μg/kg the
Ronald L, Snyder, Delevan J, Stringham
openaire   +2 more sources

Management of Hyperleukocytosis

Current Treatment Options in Oncology, 2016
Hyperleukocytosis has a high morbidity index. The involvement of the respiratory or central nervous system and the metabolic derangements accompanying tumor lysis are responsible for early mortality. Standard care for acute hyperleukocytosis must include cytoreduction, proper supportive care, and prevention of tumor lysis.
Ruggiero, Antonio, Rizzo, Daniela, Amato, Maria, Riccardi, Riccardo   +3 more
openaire   +3 more sources

Clinical Implications of Hyperleukocytosis/Leukostasis Syndrome

Journal of Modern Medical Oncology, 2023
The unusual leukemia presentation known as hyperleukocytosis (white blood cell count >100×109/L) is linked to a higher risk of premature death. Leukostasis, a syndrome brought on by the sludging of circulating leukemic blasts in the microcirculation, is ...
B. Bashir
semanticscholar   +1 more source

Hyperleukocytosis from arsenic trioxide

Pediatric Blood & Cancer, 2008
AbstractWe report the case of a 14‐year‐old male treated with arsenic trioxide for recurrent acute promyelocytic leukemia. He developed hyperleukocytosis (WBC 111.6 × 109/L) which then resolved while continuing daily arsenic. Hyperleukocytosis without other complications may not be an indication for adding cytotoxic therapy or steroids, nor for ...
Michael, Levy, Marcia M, Wofford, Bayard L, Powell, Thomas W, McLean   +3 more
openaire   +2 more sources

Hyperleukocytosis, leukostasis and leukapheresis: Practice management

Blood Reviews, 2012
Hyperleukocytosis, arbitrarily defined in acute leukemia as a white blood cell count greater than 100,000/mL, often is associated with increased morbidity and mortality in patients with leukemic processes. It can induce leukostasis, tumor lysis syndrome and disseminated intravascular coagulopathy and has significant prognostic implications with or ...
Chezi Ganzel, Jacob M Rowe
exaly   +3 more sources

Hyperleukocytosis in Acute Myeloid Leukemia: Considerations for Inpatient Diagnosis and Management.

Clinical Journal of Oncology Nursing, 2023
Hyperleukocytosis, a white blood cell count greater than 100,000/mcl, can be associated with the following three primary oncologic emergencies: leukostasis, disseminated intravascular coagulation, and tumor lysis syndrome. Th.
Tia T Wheatley, Haley Foster Castiglione, Kenneth Phong, Monica Yoon   +3 more
semanticscholar   +1 more source

Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis.

Blood, 2023
We show for the first time that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia, monocytic leukemias, or ...
E. Mack, Meaghan C. Dougher, A. Ginda, Caitlin Cahill, Melissa Murter, K. Schell, Y. Tanhehco, Vijay Bhoj, A. Fesnak, Don L. Siegel, Taku Kambayashi, N. Aqui, U. O'Doherty   +12 more
semanticscholar   +1 more source

The effect of the time from diagnosis to induction therapy on prognosis in patients with acute leukemia undergoing leukapheresis for symptomatic hyperleukocytosis

Therapeutic apheresis and dialysis, 2023
Our study investigated leukapheresis's effect on delayed induction therapy outcomes in patients with acute leukemia presenting with symptomatic hyperleukocytosis.
I. E. Pınar, V. Özkocaman, Tuba Ersal, Mehmet Emin Dağtekin, Cumali Yalçın, Bedrettin Orhan, Ömer Candar, Sinem Çubukçu, Tuba Güllü Koca, Vildan Gürsoy, Fahir Özkalemkaş   +10 more
semanticscholar   +1 more source

Approach to hyperleukocytosis and leukostasis- inpatient management strategies.

Journal of Hospital Medicine
Hyperleukocytosis is defined as a white blood cell count exceeding 100,000/µL and is a critical manifestation of acute and chronic leukemia. It can lead to life-threatening complications such as leukostasis, disseminated intravascular coagulation, and ...
M. Baral, S. Bhandari
semanticscholar   +1 more source