Results 81 to 90 of about 1,628 (190)

Draft genome sequence of a carbapenemase-producing (NDM-1) and multidrug-resistant, hypervirulent Klebsiella pneumoniae ST11 isolate from Pakistan, with a non-hypermucoviscous phenotype associated with rmpA2 mutation [PDF]

, 2021
Objectives ST11 is a high-risk sequence type associated with carbapenem-resistant Klebsiella pneumoniae strains. Carbapenemase-producing hypervirulent K. pneumoniae (hvKp) are a major concern as they harbour a diverse range of pathogenicity traits. Here
Imtiaz, Wajiha, Andrews, Simon C., Dasti, Javid Iqbal   +2 more
core   +1 more source

Intramedullary spinal cord abscess due to disseminated hypermucoviscous Klebsiella pneumoniae infection: A rare case report. [PDF]

Heliyon
Background: Intramedullary spinal cord abscess (ISCA) is a rare and serious condition with high disability and mortality rates. Klebsiella pneumoniae (K. pneumoniae) is known for its aggressive and disseminated abscess formation.
He J, Xie J, Niu C.
europepmc   +2 more sources

Antibacterial and Antibiotic‐Enhancing Activity of 3‐Hydroxy‐4‐methoxycinnamic Acid: Experimental Data and In Silico Predictions

ChemistrySelect, Volume 10, Issue 47, December 15, 2025.
ABSTRACT The growing bacterial resistance, driven by the inappropriate use of antibiotics, poses a global health threat and demands new therapeutic strategies. Natural phenolic compounds, such as 3‐hydroxy‐4‐methoxycinnamic acid (3H4MCA), stand out due to their antimicrobial and antioxidant properties, showing potential in combating resistant pathogens.
José Thyálisson da Costa Silva, Viviane Bezerra da Silva, Guilherme Fernandes Teixeira, Carlos Alonso Leite dos Santos, Antonia Adeublena de Araujo Monteiro, Janaína Esmeraldo Rocha, Ewerton Yago de Sousa Rodrigues, Rafael Pereira da Cruz, Isaac Moura Araújo, Adrielle Rodrigues Costa, Cicera Laura Roque Paulo, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais‐Braga, José Maria Barbosa‐Filho, Saulo Almeida de Menezes, Henrique Douglas Melo Coutinho, José Weverton Almeida‐Bezerra   +16 more
wiley   +1 more source

Pathogenic Potential of Invasive Mucosa‐Associated Klebsiella pneumoniae Isolates in Ulcerative Colitis: Characterization of Virulence Factors and Inflammatory Response

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
This study was conducted in 83 patients with ulcerative colitis (UC). Klebsiella pneumoniae isolates showed a higher prevalence of virulence genes (fimH, hcp, fyuA, irp1) compared to non‐UC controls. UC isolates exhibited increased adhesion (29% vs. 8%) and invasion (16% vs.
Ensieh Olamafar, Abbas Yadegar, Shabnam Shahrokh, Maryam Tajabadi Ebrahimi, Hamidreza Houri   +4 more
wiley   +1 more source

Increasing Occurrence of Antimicrobial-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Isolates in China [PDF]

Clinical Infectious Diseases, 2013
New hypervirulent variants of Klebsiella pneumoniae (hvKP) are emerging globally, most of which exhibit antimicrobial susceptibility.A retrospective study was conducted in 88 patients with cultures positive for K. pneumoniae hospitalized in the Beijing You'an Hospital from April 2010 to June 2012.
Wei, Li, Guizhen, Sun, Yanhua, Yu, Ning, Li, Ming, Chen, Ronghua, Jin, Yanmei, Jiao, Hao, Wu   +7 more
openaire   +2 more sources

Occurrence and Molecular Study of Hypermucoviscous/Hypervirulence Trait in Gut Commensal K. pneumoniae from Healthy Subjects

, 2023
Hypervirulent Klebsiella pneumoniae (hvKp) is emerging worldwide. Hypermucoviscousity is the characteristic trait that distinguishes it from classic K. pneumoniae (cKp), which enables Kp to cause severe invasive infections.
Marwa Yousry A. Mohamed, Bishoy M. Zaki, Wafaa S. Khalaf, Mahmoud M. Tawfick, Dina M. Osama, Heba M. Amin   +5 more
core   +1 more source

Assessment of Hypervirulent Klebsiella pneumoniae Isolates Using Multilocus Sequence Typing in West of Iran

MicrobiologyOpen, Volume 14, Issue 4, August 2025.
This study identified eight novel sequence types (STs) of hypervirulent Klebsiella pneumoniae using MLST in western Iran. The findings highlight the genetic diversity and public health threat posed by hvKP strains. Phenotypic and genotypic methods, including PCR and MLST, were used to identify hypervirulent Klebsiella pneumoniae isolates in western ...
Mohammad Hossein Haddadi, Nourkhoda Sadeghifard, Saeed Khoshnood, Abbas Maleki, Sobhan Ghafourian, Hassan Valadbeigi   +5 more
wiley   +1 more source

A case of hypermucoviscousKlebsiella pneumoniaeliver abscess syndrome in an Iraqi male [PDF]

QJM, 2016
A 53-year-old man presented with fevers, productive cough and decreased appetite. He emigrated from Iraq 4 years ago. Chest x-ray revealed a left lung consolidation. Respiratory cultures and two sets of blood cultures grew out pan-susceptible Klebsiella pneumoniae Liver ultrasound revealed a 6.4-cm complex lesion in the left hepatic lobe.
Noora, Kazanji, Rachel E, Klein, Sadichhya, Lohani, Amy N, Mertens, Julie, Le   +4 more
openaire   +2 more sources

The global genomic landscape of hypervirulent Klebsiella pneumoniae from 1932 to 2021

mLife, Volume 4, Issue 4, Page 378-396, August 2025.
Abstract The global spread of hypervirulent Klebsiella pneumoniae (hvKp) poses a serious public health threat. In this study, we conducted genomic epidemiology analysis on 2097 global hvKp isolates, including our 900 isolates sequenced through the Illumina platform (177 of them fully sequenced through PacBio platform), representing the most ...
Xiaoyuan Jiang, Shuangshuang Li, Cuidan Li, Zhe Yin, Fangzhou Chen, Lingfei Hu, Tianyu Lu, Xiaoqiang Liu, Yinyu Wang, Guannan Ma, Xiaoyu Wang, Fei Chen, Dongsheng Zhou   +12 more
wiley   +1 more source

Mechanisms governing bacterial capsular polysaccharide attachment and chain length

Annals of the New York Academy of Sciences, Volume 1548, Issue 1, Page 80-98, June 2025.
Abstract Capsular polysaccharides (CPSs) are high‐molecular weight glycopolymers that form a capsule layer on the surface of many bacterial species. This layer serves as a crucial barrier between bacteria and their environment, protecting them from host immune responses and environmental stressors while facilitating adaptation to host niches.
Saroj Khadka, Emily L. Kinney, Brooke E. Ryan, Laura A. Mike   +3 more
wiley   +1 more source