Results 191 to 200 of about 28,027 (244)
Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction
Redox Biology, 2015 High levels of oxygen (hyperoxia) are often used to treat individuals with respiratory distress, yet prolonged hyperoxia causes mitochondrial dysfunction and excessive reactive oxygen species (ROS) that can damage molecules such as DNA.
Michael A O'Reilly, Paul S Brookes
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Wound Repair and Regeneration, 2005
We hypothesized that tissue hyperoxia would enhance and hypoxia inhibit neovascularization in a wound model. Therefore, we used female Swiss‐Webster mice to examine the influence of differential oxygen treatment on angiogenesis. One milliliter plugs of Matrigel®, a mixture of matrix proteins that supports but does not itself elicit angiogenesis, were ...
Harriet W, Hopf +7 more
openaire +2 more sources
We hypothesized that tissue hyperoxia would enhance and hypoxia inhibit neovascularization in a wound model. Therefore, we used female Swiss‐Webster mice to examine the influence of differential oxygen treatment on angiogenesis. One milliliter plugs of Matrigel®, a mixture of matrix proteins that supports but does not itself elicit angiogenesis, were ...
Harriet W, Hopf +7 more
openaire +2 more sources
Best Practice & Research Clinical Anaesthesiology, 2008
Surgical wound infection remains a common and serious complication of surgery. Patient factors are a major determinant of wound outcome following surgery. Co-morbidities clearly contribute, but environmental stressors as well the individual response to stress may be equally important. In particular, wounds are exquisitely sensitive to hypoxia, which is
Harriet W, Hopf, James, Holm
openaire +2 more sources
Surgical wound infection remains a common and serious complication of surgery. Patient factors are a major determinant of wound outcome following surgery. Co-morbidities clearly contribute, but environmental stressors as well the individual response to stress may be equally important. In particular, wounds are exquisitely sensitive to hypoxia, which is
Harriet W, Hopf, James, Holm
openaire +2 more sources
Emerging role of metabolic reprogramming in hyperoxia-associated neonatal diseases
Redox Biology, 2023 Oxygen therapy is common during the neonatal period to improve survival, but it can increase the risk of oxygen toxicity. Hyperoxia can damage multiple organs and systems in newborns, commonly causing lung conditions such as bronchopulmonary dysplasia ...
He Zhang +4 more
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Hypoxic ventilatory responses in rats after hypercapnic hyperoxia and intermittent hyperoxia
Respiratory Physiology and Neurobiology, 2007Perinatal hyperoxia attenuates the adult hypoxic ventilatory response in rats. Hyperoxia might elicit this plasticity by inhibiting chemoreceptor activity during early life. Thus, we hypothesized that stimulating chemoreceptors with CO(2) during hyperoxia or interrupting hyperoxia with periods of normoxia would reduce the effects of hyperoxia on the ...
Ryan W Bavis, Jessica P Otis
exaly +3 more sources
Current Opinion in Pulmonary Medicine, 1998
Experimental studies and few human reports demonstrate that hyperoxia increases the level of reactive oxygen-derived free radicals and that these substances can produce oxidative cellular injury. However, available data suggest that the human lung is more resistant to hyperoxic oxidative damage than previously expected and demonstrate that absorption ...
C R, Carvalho +3 more
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Experimental studies and few human reports demonstrate that hyperoxia increases the level of reactive oxygen-derived free radicals and that these substances can produce oxidative cellular injury. However, available data suggest that the human lung is more resistant to hyperoxic oxidative damage than previously expected and demonstrate that absorption ...
C R, Carvalho +3 more
openaire +2 more sources
Chest, 1974
N umerous studies have been conducted on the pathologic changes that occur in the lung due to exposure to hyperbaric oxygen. These studies indicate that the entire lung, from the epithelium of the upper respiratory tract down to the pulmonary capillary endothelium, can be damaged by prolonged exposure to elevated partial pressures of oxygen.' Reports ...
W D, Currie, P C, Pratt, A P, Sanders
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N umerous studies have been conducted on the pathologic changes that occur in the lung due to exposure to hyperbaric oxygen. These studies indicate that the entire lung, from the epithelium of the upper respiratory tract down to the pulmonary capillary endothelium, can be damaged by prolonged exposure to elevated partial pressures of oxygen.' Reports ...
W D, Currie, P C, Pratt, A P, Sanders
openaire +2 more sources
Critical Care Medicine, 2010
The current practice of mechanical ventilation comprises the use of the least inspiratory O2 fraction associated with an arterial O2 tension of 55 to 80 mm Hg or an arterial hemoglobin O2 saturation of 88% to 95%. Early goal-directed therapy for septic shock, however, attempts to balance O2 delivery and demand by optimizing cardiac function and ...
Calzia, Enrico +6 more
openaire +5 more sources
The current practice of mechanical ventilation comprises the use of the least inspiratory O2 fraction associated with an arterial O2 tension of 55 to 80 mm Hg or an arterial hemoglobin O2 saturation of 88% to 95%. Early goal-directed therapy for septic shock, however, attempts to balance O2 delivery and demand by optimizing cardiac function and ...
Calzia, Enrico +6 more
openaire +5 more sources