Results 141 to 150 of about 26,081 (268)

Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression

Journal of Integrative Neuroscience
Background: Different types of stress inflicted in early stages of life elevate the risk, among adult animals and humans, to develop disturbed emotional-associated behaviors, such as hyperphagia or depression.
Viridiana Alcántara-Alonso, Cinthia García-Luna, Paulina Soberanes-Chávez, Erika Estrada-Camarena, Patricia de Gortari   +4 more
doaj   +1 more source

Sex‐Specific Anti‐Inflammatory Effects of Alternate Day Fasting via TLR4 and Leptin Signaling in Middle‐Aged Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ADF downregulates TLR4, reducing hypothalamic and hepatic inflammation, with stronger effects in females. ADF enhances leptin sensitivity in aging by reducing SOCS3 and upregulating ObRb, thereby improving metabolic function. ADF reduces retroperitoneal fat and glucose levels, with females experiencing greater fat loss.
Ozgen Kilic‐Erkek, Gulsah Gundogdu, Abdullah Coguplugil, Yavuz Dodurga   +3 more
wiley   +1 more source

Case Report: Improvement in cognitive functioning following setmelanotide initiation in a patient with Bardet-Biedl syndrome

Frontiers in Endocrinology
Bardet-Biedl syndrome (BBS) is a rare genetic condition that results from mutations in a variety of genes crucial for ciliary transport. Consequently, patients with BBS present with a wide array of clinical signs and symptoms that include multiple organ ...
Menjin Kuk, Jesse Richards, Rachel A. Ross   +2 more
doaj   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Prader-Willi and Angelman Syndromes: Mechanisms and Management

The Application of Clinical Genetics, 2023
Van K Ma,1,2 Rong Mao,3,4 Jessica N Toth,3 Makenzie L Fulmer,3,4 Alena S Egense,1,2 Suma P Shankar1,2,5 1Department of Pediatrics, University of California Davis, Sacramento, CA, USA; 2MIND Institute, University of California Davis, Sacramento, CA, USA ...
Ma VK, Mao R, Toth JN, Fulmer ML, Egense AS, Shankar SP   +5 more
doaj  

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6919-6926, August 2026.
ABSTRACT Aims The brain plays a critical role in controlling energy balance. Previous studies have mainly focused on dopaminergic mechanisms, whereas much less attention has been paid to serotonin during the emergence of overweight and obesity. Therefore, this study investigated the association between serotonin transporter (SERT) availability and ...
Kyoungjune Pak
wiley   +1 more source

Alpha1- and alpha2-containing GABA(A) receptor modulation is not necessary for benzodiazepine-induced hyperphagia [PDF]

, 2009
Benzodiazepines increase food intake, an effect attributed to their ability to enhance palatability. We investigated which GABAA receptor subtypes may be involved in mediating benzodiazepine-induced hyperphagia.
H V Morris (16056941), D N Stephens (16042424), Claire Dixon (4461196), Pete Clifton (4460347), S Nilsson (13292823)   +4 more
core   +2 more sources

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Participação de a-adrenoceptores do núcleo mediano da rafe no controle da resposta ingestiva em ratos saciados [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O presente estudo avaliou a participação de a-adrenoceptores do núcleo mediano da rafe (NMR ...
Levone, Brunno Rocha
core