Results 111 to 120 of about 486,131 (299)

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

eLife, 2013
How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a ...
Katarzyna Nowak, Gerhard Seisenbacher, Ernst Hafen, Hugo Stocker   +3 more
doaj   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Advanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He, Jing Li, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yingming Xu, Shuang Ge, Yexing Zhang, Yizhi Wang, Xinrui Chen, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Peizhen Hu, Qiang Huang, Zihan Wang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Jiurun Chen, Zhen Song, Chao He, Zhe Wang, Yonghong He   +28 more
wiley   +1 more source

Malignant transformation in oral epithelial dysplasticlesions: An observational study

Journal of Health Sciences
Introduction: This research study is a comprehensive analysis of cases oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) over the past decade, with a particular focus on eliciting the frequency of malignant transformation (MT) of ...
Anuhya Jayanthi, Sagar Krishna, Sunitha Carnelio, Vasudeva Guddattu, Spoorti Kulkarni   +4 more
doaj   +1 more source

Supplementation of grazing beef cows during gestation as a strategy to improve skeletal muscle development of the offspring

Animal, 2017
The appropriate supply of nutrients in pregnant cows has been associated with the optimal development of foetal tissues, performance of their progeny and their meat quality. The aim of this study was to evaluate supplementation effects of grazing cows in
D.C. Marquez, M.F. Paulino, L.N. Rennó, F.C. Villadiego, R.M. Ortega, D.S. Moreno, L.S. Martins, D.M. de Almeida, M.P. Gionbelli, M.R. Manso, L.P. Melo, F.H. Moura, M.S. Duarte   +12 more
doaj   +1 more source

Intra-cavitary uterine pathology in women with abnormal uterine bleeding: a prospective study of 1220 women. [PDF]

, 2015
OBJECTIVES: Our primary aim was to assess how patients characteristics, bleeding pattern, sonographic endometrial thickness (ET) and additional features at unenhanced ultrasound examination (UTVS) and at fluid instillation sonography (FIS) contribute to ...
Ameye, L, Bourne, T, Timmerman, D, Van den Bosch, T, Van Schoubroeck, D   +4 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Verrucous Hyperplasia : Case report and differential diagnosis

Sultan Qaboos University Medical Journal, 2017
Verrucous hyperplasia (VH) is a rare exophytic oral mucosal lesion which can transform into verrucous carcinoma (VC), its malignant but clinically similar counterpart.
Sonal Grover, Mihir Jha, Bhushan Sharma, Shekhar Kapoor, Kumud Mittal, Nithin K. Parakkat, Anil B. Shivappa, Ravleen Kaur   +7 more
doaj   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Hypoplastic Left Heart Syndrome: A New Paradigm for an Old Disease?

Journal of Cardiovascular Development and Disease, 2019
Hypoplastic left heart syndrome occurs in up to 3% of all infants born with congenital heart disease and is a leading cause of death in this population. Although there is strong evidence for a genetic component, a specific genetic cause is only known in ...
Paul Grossfeld, Shuyi Nie, Lizhu Lin, Lu Wang, Robert H. Anderson   +4 more
doaj   +1 more source