Results 111 to 120 of about 567,888 (305)

Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

eLife, 2013
How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a ...
Katarzyna Nowak, Gerhard Seisenbacher, Ernst Hafen, Hugo Stocker   +3 more
doaj   +1 more source

Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, In Vivo and the Impact of Metformin In Vitro

International Journal on Biological Sciences, 2019
The underlying mechanisms of polycystic ovarian syndrome (PCOS)-induced endometrial dysfunction are not fully understood, and although accumulating evidence shows that the use of metformin has beneficial effects in PCOS patients, the precise regulatory ...
Tao Wang, Jiao Zhang, Min Hu, Yue-Hui Zhang, P. Cui, Xin Li, Juan Li, Edvin Vestin, M. Brännström, Linus R. Shao, H. Billig   +10 more
semanticscholar   +1 more source

Benign Prostate Hyperplasia

, 2017
Benign prostatic hyperplasia (BPH) also known as benign enlargement of the prostate (BEP or BPE) by definition is the nonmalignant increase in size of the prostate gland.
Saku, Magdalene
core  

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Malignant transformation in oral epithelial dysplasticlesions: An observational study

Journal of Health Sciences
Introduction: This research study is a comprehensive analysis of cases oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC) over the past decade, with a particular focus on eliciting the frequency of malignant transformation (MT) of ...
Anuhya Jayanthi, Sagar Krishna, Sunitha Carnelio, Vasudeva Guddattu, Spoorti Kulkarni   +4 more
doaj   +1 more source

Supplementation of grazing beef cows during gestation as a strategy to improve skeletal muscle development of the offspring

Animal, 2017
The appropriate supply of nutrients in pregnant cows has been associated with the optimal development of foetal tissues, performance of their progeny and their meat quality. The aim of this study was to evaluate supplementation effects of grazing cows in
D.C. Marquez, M.F. Paulino, L.N. Rennó, F.C. Villadiego, R.M. Ortega, D.S. Moreno, L.S. Martins, D.M. de Almeida, M.P. Gionbelli, M.R. Manso, L.P. Melo, F.H. Moura, M.S. Duarte   +12 more
doaj   +1 more source

Pharmacological treatment of benign prostatic hyperplasia

, 2017
Lower urinary tract symptoms (LUTS) is the major clinical manifestation of benign prostatic hyperplasia (BPH) which is one of the most common disorders that affects the aging male population.
Economou, Spyros
core  

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Verrucous Hyperplasia : Case report and differential diagnosis

Sultan Qaboos University Medical Journal, 2017
Verrucous hyperplasia (VH) is a rare exophytic oral mucosal lesion which can transform into verrucous carcinoma (VC), its malignant but clinically similar counterpart.
Sonal Grover, Mihir Jha, Bhushan Sharma, Shekhar Kapoor, Kumud Mittal, Nithin K. Parakkat, Anil B. Shivappa, Ravleen Kaur   +7 more
doaj   +1 more source

Adipose tissue fibrosis, hypertrophy, and hyperplasia: correlations with diabetes in human obesity

Obesity, 2016
The relationship between adipose tissue fibrosis, adipocyte hypertrophy, and preadipocyte hyperplasia in the context of obesity and the correlation of these tissue‐based phenomena with systemic metabolic disease are poorly defined. The goal of this study
Lindsey A. Muir, C. Neeley, Kevin A. Meyer, Nicki A. Baker, Alice M. Brosius, Alexandra R. Washabaugh, O. Varban, Jonathan F. Finks, B. Zamarron, C. Flesher, Joshua S. Chang, Jennifer B. Delproposto, L. Geletka, Gabriel Martinez-Santibanez, N. Kaciroti, C. Lumeng, Robert W. O’Rourke   +16 more
semanticscholar   +1 more source