Results 251 to 260 of about 129,353 (325)

Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx

The Journal of Physiology, EarlyView.
Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise, Heather L. Struckman, James W. Smyth, Gregory S. Hoeker, Steven Poelzing, Rengasayee Veeraraghavan, Seth H. Weinberg   +6 more
wiley   +1 more source

Extracellular salt bridge networks around S4 implicated in HCN channel gating and heart disease. [PDF]

Proc Natl Acad Sci U S A
Ryu K, Kasuya G, Nakajo K.
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Single-scan detection of ligand-binding using hyperpolarization and low-field relaxation. [PDF]

Commun Chem
Narwal P, Lorz N, Minaei M, Gossert AD, Meier B.   +4 more
europepmc   +1 more source

Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin

The Journal of Physiology, EarlyView.
Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George, Amber V. Mills, Erin O'Neill, Sofian N. Obaid, Igor R. Efimov, Tatiana Efimova   +5 more
wiley   +1 more source

¹H/¹⁵N NMR and Low-Field ¹H MRI of SABRE-Hyperpolarized Pyrazinamide─An Approved Antibiotic and Potential MRI Contrast Agent. [PDF]

J Phys Chem B
Siraj Z, Petrilla AF, Senanayake IM, Iqbal N, Gyesi JN, Westerfield J, Daluwathumullagamage PJ, Shchepin RV, Ragunathan S, Chekmenev EY, Goodson BM.   +10 more
europepmc   +1 more source

Hyperpolarized Xenon 129 [PDF]

, 2020
openaire   +1 more source

Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3077-3094, June 2026.
ABSTRACT Purpose We present a method for absolute quantification of deuterated metabolites in vivo at 7T. We describe acquisition protocols and an analysis pipeline compatible with 7T Terra MRIs. We apply them using a 2H/1H receive array in healthy volunteers and glioblastoma patients.
Jabrane Karkouri, Masha Novoselova, Sarah Miller, Minghao Zhang, Alexandra Constantinou, Carina Graf, Özlem Ipek, Daniel Atkinson, Brandon Tramm, Scott Schillak, Richard Mair, Kevin Brindle, Christopher T. Rodgers   +12 more
wiley   +1 more source

Coherent Control over Nuclear Hyperpolarization Using an Optically Initializable Chromophore-Radical System. [PDF]

J Am Chem Soc
Le HM, Straub JS, Stern Q, Equbal A, Qiu Y, Krzyaniak MD, Wasielewski MR, Han S.   +7 more
europepmc   +1 more source

Comparison of Signal‐ and Volume‐Based Ventilation‐Weighted Assessment Using 3D FLORET UTE MRI in Patients With Various Pulmonary Disease

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2814-2827, May 2026.
ABSTRACT Purpose 3D free‐breathing, proton, contrast‐agent‐free MR methods are increasingly used for pulmonary ventilation‐weighted measurements. The methods are split between: (1) signal‐based, which rely on lung parenchyma signal changes during respiration, and (2) volume‐based that utilize the Jacobian determinant of deformation fields from the ...
Filip Klimeš, Joseph W. Plummer, Andreas Voskrebenzev, Marcel Gutberlet, Marius M. Klein, Matthew M. Willmering, Alexander M. Matheson, Abdullah S. Bdaiwi, Frank Wacker, Jason C. Woods, Zackary I. Cleveland, Laura L. Walkup, Jens Vogel‐Claussen   +12 more
wiley   +1 more source