Results 241 to 250 of about 61,022 (308)

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Quantification of Ligand-Membrane Interactions Using DNP-NMR Relaxometry. [PDF]

Anal Chem
Qi C, Pradhan N, Hilty C.
europepmc   +1 more source

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source

MRI for Mixing Quality in Microfluidics

Magnetic Resonance in Chemistry, Volume 64, Issue 7, Page 600-607, July 2026.
Fluidic mixing in a micromixer: Paramagnetic relaxation enhancement and chemical shift differences were explored to reveal mixing quality at the small dimensions of an optically opaque y‐mixer. ABSTRACT Liquid state processes often involve mixing of process streams.
J. Götz, T. Rudszuck, L. Kontschak, T. Oerther, H. Nirschl, G. Guthausen   +5 more
wiley   +1 more source

<i>J</i>-Resolved Molecular Fingerprinting by Parahydrogen Hyperpolarized Low-Field NMR. [PDF]

J Am Chem Soc
Zhang Z, Savukov I, Hilty C.
europepmc   +1 more source

Physiological Interpretation of the Lactate to Pyruvate AUC Ratio for Hyperpolarized [1‐13C]‐Pyruvate Studies

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 247-258, July 2026.
ABSTRACT Purpose To explore the relationship between potentially rate‐limiting steps in lactate production and the lactate area‐under‐the‐curve (AUC) to pyruvate AUC ratio for analysis of hyperpolarized (HP) [1‐13C]‐pyruvate data. Theory and Methods Simplifying assumptions are introduced to a pharmacokinetic (PK) model with three physical compartments ...
Ryan T. Boyce, Collin J. Harlan, Qing Wang, Christopher M. Walker, Stephen Y. Lai, Matthew E. Merritt, James A. Bankson   +6 more
wiley   +1 more source

Optimized Detection of Left Ventricular Hyperpolarized [1‐13C]Pyruvate Signal in Human Cardiac Metabolic Imaging

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 420-434, July 2026.
ABSTRACT Purpose This study aimed to improve the analysis of the left ventricular (LV) blood pool hyperpolarized [1‐13C]pyruvate signal for a more reliable quantification of downstream metabolic outcome. Methods Hyperpolarized [1‐13C]pyruvate magnetic resonance spectroscopic images were acquired dynamically at 3 Tesla in 106 participants (NCT03685175).
Fatemeh Khashami, Ivan E. Dimitrov, Maximilian Fuetterer, Stefan Glöggler, Bei Zhang, Egzona Tan, Sebastian Kozerke, Anke Henning, Tarique Hussain, Craig R. Malloy, Nisha Unni, Vlad G. Zaha, CTOX Trial Investigator(s), Sheeba Cantanelli, Isaac Chan, Suzanne Cole, Suzanne Conzen, Glenda Delgado, Deborah Farr, Joshua Gruber, Barbara Haley, Dawn Klemow, Jenny Li, Heather McArthur, Alka Mallik, Poorni Manohar, Ina Patel, Namrata Peswani, Sangeetha Reddy, Navid Sadeghi, Samira Syed   +30 more
wiley   +1 more source

Post-synaptic facilitation and network dynamics underlying stimulus-specific combination sensitivity. [PDF]

iScience
Merabi Z, Daou A.
europepmc   +1 more source

Across-cities transportable ¹³C hyperpolarization using UV-induced labile radicals. [PDF]

Nat Commun
Capozzi A, Karlsson M, Zhao Y, Kilund J, Hansen ESS, Bertelsen LB, Laustsen C, Ardenkjær-Larsen JH, Lerche MH.   +8 more
europepmc   +1 more source