Incidence and timing of biphasic anaphylactic reactions: a retrospective cohort study
Aim We investigated the frequency of overall biphasic reactions, biphasic reactions that met the diagnostic criteria of anaphylaxis, and biphasic reactions that caused a severe abnormality in vital signs in patients who visited the emergency department ...
Motohiro Ichikawa+3 more
doaj +1 more source
Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]
Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
Almeida, C.+5 more
core +2 more sources
Cytotoxic Proteins and Therapeutic Targets in Severe Cutaneous Adverse Reactions
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are rare but life-threatening conditions induced mainly by a variety of drugs.
Shih-Chi Su, Wen-Hung Chung
doaj +1 more source
Background: The present study aims to assess area of open dentinal tubules by use of diode laser and electrode alone and in combination with hydroxyapatite powder and strontium chloride powder by using the scanning electron microscope (SEM).
Chitra Laxmikant Patil+1 more
doaj +1 more source
Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials [PDF]
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety ...
Atkinson, John P+14 more
core +2 more sources
Quality of Life in Patients with Allergic Rhinitis in the North of Iran [PDF]
Introduction: Allergic Rhinitis (AR) is a chronic disease which affects the quality of life in adult patients. Fatigue, impairment of sleep quality and sexual dysfunction might be manifestations of the quality of life impairment in adults.
Jalali Mir Mohammad+3 more
doaj +1 more source
Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. [PDF]
To investigate a potential mechanism underlying trigeminal nerve injury-induced orofacial hypersensitivity, we used a rat model of chronic constriction injury to the infraorbital nerve (CCI-ION) to study whether CCI-ION caused calcium channel α2δ1 ...
Kim, Doo-Sik+7 more
core +1 more source
Hypersensitivity to Perturbations in the Quantum Baker's Map [PDF]
We analyze a randomly perturbed quantum version of the baker's transformation, a prototype of an area-conserving chaotic map. By numerically simulating the perturbed evolution, we estimate the information needed to follow a perturbed Hilbert-space vector
A. Peres+20 more
core +4 more sources
The effects of coloring therapy on patients with generalized anxiety disorder
After the intervention, there were statistical differences intra‐and‐inter group comparisons of anxiety, depression, and positive and negative mood scales in the experimental and control groups (p < .05). The minus in anxiety/positive emotions pre‐and‐post intervention in the experimental group was statistically significant compared to the minus in ...
Bosomtwe Samuel+6 more
wiley +1 more source
Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication [PDF]
Replication Protein A (RPA) is a heterotrimeric protein complex that binds single-stranded DNA. In plants, multiple genes encode the three RPA subunits (RPA1, RPA2 and RPA3), including five RPA1-like genes in Arabidopsis.
Aklilu, Behailu B.+2 more
core +5 more sources