Results 31 to 40 of about 358,537 (259)

Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life [PDF]

, 2007
Background: prevalence and incidence of food hypersensitivity (FHS) and its trends in early childhood are unclear. Methods: a birth cohort born on the Isle of Wight (UK) between 2001 and 2002 was followed-up prospectively.
Grundy, J., K. Voigt, Clayton, C., Venter, Carina, Dean, T., Higgins, B., Arshad, S., Pereira, B., B. Higgins, Arshad, Syed Hasan, Venter, C., Grundy, Jane D., Clayton, C.B., C. B. Clayton, T. Dean, Dean, Taraneh, Voigt, K., Higgins, Bernard, S. H. Arshad, C. Venter, B. Pereira, Dean, Tara, J. Grundy   +22 more
core   +1 more source

HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review

Journal of Immunology Research, 2014
T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome ...
Chi-Yuan Cheng, Shih-Chi Su, Chi-Hua Chen, Wei-Li Chen, Shin-Tarng Deng, Wen-Hung Chung   +5 more
doaj   +1 more source

Epigenetic differences between monozygotic twins and their relation to hypersensitivity reactions

, 2022
My goal was to bring an understanding of the complex phenomena of epigenetics and its different mechanisms that can be closely monitored by the help of twin studies specifically focusing on monozygotic twins and discordant studies to explore its ...
Javkhlant, Usukhzaya
core  

Severe cutaneous adverse reactions associated with systemic antibiotics in acne vulgaris: a systematic review

Journal of Dermatological Treatment
Background Acne vulgaris (AV) is an inflammatory disorder of the pilosebaceous unit commonly managed with systemic antibiotics. Since antibiotics are known triggers of severe cutaneous adverse drug reaction (SCARs), patients with AV receiving prolonged ...
Ivan Arni C. Preclaro, Po-Chien Wu, Mary Caroline Go, Wen-Hung Chung, Chun-Bing Chen   +4 more
doaj   +1 more source

Clinical Characteristics and Disease Burden of Patients with Moderate-to-Severe Generalized Pustular Psoriasis Flares in Taiwan

Dermatology and Therapy
Introduction Generalized pustular psoriasis (GPP) is a rare and severe psoriasis subtype characterized by the rapid onset of coalescing sterile pustules over broad body areas and systemic inflammation.
Chun-Wei Lu, Chien-Yu Tseng, Chuang-Wei Wang, Shang-Hung Lin, Chun-Bing Chen, Rosaline Chung-Yee Hui, Ching-Chi Chi, Yu-Huei Huang, Chih-Hung Lee, Fang-Ju Lin, Wen-Hung Chung   +10 more
doaj   +1 more source

A Novel System to Diagnose Cutaneous Adverse Drug Reactions Employing the Cellscan—Comparison with Histamine Releasing Test and Inf-γ Releasing Test

Clinical and Developmental Immunology, 2005
Background: There are several mechanisms to describe allergic drug reactions yet the methods to diagnose them are limited.
Ilan Goldberg, Boris Gilburd, Martine Szyper Kravitz, Shmuel Kivity, Berta Ben Chaim, Tirza Klein, Yael Schiffenbauer, Ela Trubniykovr, Sarah Brenner, Yehuda Shoenfeld   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade

Nature Communications
Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis ...
Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung   +31 more
doaj   +1 more source

Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli

Physiological Reports, 2020
Galanin is a neuropeptide expressed by sensory neurones innervating the gastrointestinal (GI) tract. Galanin displays inhibitory effects on vagal afferent signaling within the upper GI tract, and the goal of this study was to determine the actions of ...
Toni S. Taylor, Parvesh Konda, Sarah S. John, David C. Bulmer, James R. F. Hockley, Ewan St. John Smith   +5 more
doaj   +1 more source

Viral Infections and Cutaneous Drug-Related Eruptions

Frontiers in Pharmacology, 2021
In the general population, up to 10% of children treated by antibiotics have cutaneous adverse drug reaction, but allergy is confirmed in less than 20% of patients.
Eleonora Anci, Camille Braun, Camille Braun, Annalisa Marinosci, Frédérique Rodieux, Elise Midun, Elise Midun, Maria-Jose Torres, Jean-Christoph Caubet   +8 more
doaj   +1 more source