Results 31 to 40 of about 369,698 (260)

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. [PDF]

, 2015
BackgroundMechanical pain hypersensitivity associated with physical trauma to peripheral nerve depends on T-helper (Th) cells expressing the algesic cytokine, interleukin (IL)-17A.
Angert, Mila, Chernov, Andrei V, Dolkas, Jennifer, Hoang, Khan, Liu, Huaqing, Nishihara, Tasuku, Remacle, Albert G, Shiryaev, Sergey A, Shubayev, Veronica I, Strongin, Alex Y   +9 more
core   +3 more sources

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

Mechanisms of Hypersensitivity [PDF]

, 2013
Allergic reactions to drugs are not always the result of the drug’s protein-binding capacity, biotransformation, or degradation. Mediator release may occur via cross-linking of cell-bound IgE by di-(multi-) valent free drug. Physiological and pharmacological effects of histamine are mediated through four receptors, H(1), H(2), H(3), and H(4.) The H(3 ...
Brian A. Baldo, Nghia H. Pham
openaire   +2 more sources

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Reactions to synthetic membranes dialyzers: Is there an increase in incidence? [PDF]

, 2019
Background: Reactions to dialyzers used in dialysis have been reported more frequently in recent years. Evidence, however, shows that the reaction rate has remained stable for years.
Carriazo, Sol, Castillo, Emeralda, Esteras, Raquel, Fernández Prado, Raúl, González Parra, Emilio, Gracia Iguacel, Carolina, Martín Navarro, Juan, Mas Fontao, Sebastian, Ortiz, Alberto   +8 more
core   +2 more sources

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Hyperacusis in children: a preliminary study on the effects of hypersensitivity to sound on speech and language [PDF]

, 2018
There is a growing awareness that children may experience hyperacusis, a condition that is often associated with behavioral and developmental disorders.
Antonella Polimeni, Antonio Greco, Giancarlo Altissimi, Giancarlo Cianfrone, Laura Carchiolo, Marco de Vincentiis, Massimo Fusconi, Massimo Ralli, Natalia Tagliaferri, Rosaria Turchetta   +9 more
core   +1 more source

Hypersensitivity Angiitis

Journal of Investigative Dermatology, 1989
Hypersensitivity angiitis is a disease in which patients present with palpable purpura dominant on the lower legs. As lesions evolve they become confluent, and sometimes hemorrhagic and ulcerate. Other organ systems may be involved, particularly the joints, gastrointestinal tract, and kidneys. Current evidence supports an immune complex pathogenesis in
openaire   +2 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source